Q. How does chemotherapy work to treat cancer?
Doctor Answer is medically reviewed by SecondMedic medical review team.
Chemotherapy works to treat cancer by targeting and killing rapidly dividing cells, including cancer cells. It uses drugs that are designed to disrupt the process of cell division and interfere with the growth and spread of cancer. Here's a more detailed explanation of how chemotherapy works:
1. Cell Division and Cancer: Cancer is characterized by the uncontrolled growth and division of abnormal cells within the body. These rapidly dividing cancer cells can form tumors and spread to other parts of the body through the bloodstream or lymphatic system.
2. Targeting Rapidly Dividing Cells: Chemotherapy drugs are cytotoxic, meaning they are toxic to cells. They specifically target and damage cells that are actively dividing. Since cancer cells divide more rapidly than most normal cells, they are particularly vulnerable to chemotherapy.
3. Interfering with Cell Division: Chemotherapy drugs disrupt various stages of the cell division cycle. They may affect DNA replication, cell division, and the formation of new cells. By interfering with these processes, chemotherapy can prevent cancer cells from multiplying.
4. Systemic Treatment: Chemotherapy is often administered systemically, meaning it circulates throughout the body via the bloodstream. This allows the drugs to reach cancer cells in different parts of the body, including those that may not be visible on imaging scans.
5. Combination Therapies: In some cases, multiple chemotherapy drugs with different mechanisms of action may be used in combination. This approach can target cancer cells more effectively and reduce the likelihood of resistance.
6. Adjuvant and Neoadjuvant Therapy: Chemotherapy can be used as adjuvant therapy after surgery or radiation to destroy any remaining cancer cells and reduce the risk of cancer recurrence. Neoadjuvant therapy is given before surgery to shrink tumors, making them easier to remove.
7. Personalized Treatment: The choice of chemotherapy drugs and the treatment plan are tailored to the specific type and stage of cancer, as well as the individual patient's overall health and treatment goals.
8. Side Effects: While chemotherapy is effective against cancer cells, it can also affect normal, healthy cells that divide rapidly, leading to side effects such as nausea, vomiting, fatigue, hair loss, and changes in blood cell counts. Managing these side effects is an important part of cancer care.
It's worth noting that not all chemotherapy drugs work in the same way, and the choice of drugs and treatment regimen depends on the type of cancer being treated. Additionally, advances in cancer research have led to the development of targeted therapies and immunotherapies, which are more selective in their action and may have fewer side effects compared to traditional chemotherapy. Treatment decisions are typically made by a medical oncologist based on the specific characteristics of the cancer and the patient's individual circumstances.