Q. What are opportunistic infections in HIV/AIDS?
Doctor Answer is medically reviewed by SecondMedic medical review team.
Opportunistic infections are infections caused by pathogens that usually do not cause illness in individuals with a healthy immune system but can become active and cause disease in people with weakened immune systems, such as those with advanced HIV/AIDS. These infections take advantage of the weakened immune defenses, particularly a low CD4 cell count, in individuals with HIV. Common opportunistic infections associated with HIV/AIDS include:
1. Pneumocystis jirovecii Pneumonia (PCP):
- PCP is a fungal infection of the lungs that can cause severe respiratory symptoms, including cough, shortness of breath, and fever.
2. Toxoplasmosis:
- This is a parasitic infection caused by the protozoan Toxoplasma gondii. It can affect the brain, causing symptoms such as confusion, seizures, and headaches.
3. Mycobacterium avium Complex (MAC):
- MAC is a bacterial infection that can affect various organs, including the lungs, intestines, and bone marrow.
4. Candidiasis:
- Candida is a type of yeast that can cause infections in the mouth (oral thrush), throat, esophagus, and genital areas.
5. Cryptococcal Meningitis:
- Cryptococcus is a fungus that can cause inflammation of the membranes covering the brain and spinal cord, leading to symptoms like headache, fever, and neck stiffness.
6. Cytomegalovirus (CMV):
- CMV is a herpesvirus that can cause a range of symptoms, including vision problems, pneumonia, and gastrointestinal issues.
7. Mycobacterium tuberculosis (TB):
- TB is a bacterial infection that primarily affects the lungs but can spread to other organs in individuals with weakened immune systems.
8. Kaposi's Sarcoma:
- While not an infection, Kaposi's sarcoma is a cancer that is strongly associated with advanced HIV/AIDS. It causes lesions on the skin and can also affect internal organs.
9. Progressive Multifocal Leukoencephalopathy (PML):
- PML is a rare viral infection of the brain caused by the JC virus. It can lead to neurological symptoms, including weakness, paralysis, and cognitive changes.
10. Herpes Simplex Virus (HSV):
- HSV can cause recurrent sores around the mouth or genitals, and in individuals with weakened immune systems, it may lead to more severe and prolonged infections.
Preventing and managing opportunistic infections is a crucial aspect of HIV/AIDS care. Antiretroviral therapy (ART) helps strengthen the immune system and reduces the risk of opportunistic infections. Prophylactic medications may also be prescribed to prevent specific infections in individuals with low CD4 counts. Regular medical monitoring and prompt treatment of infections are essential components of comprehensive HIV care.
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