Q. What are the potential side effects of immunotherapy?
Doctor Answer is medically reviewed by SecondMedic medical review team.
Immunotherapy has been a significant advancement in the treatment of cancer and autoimmune diseases, but like any medical treatment, it can be associated with potential side effects. The side effects of immunotherapy can vary depending on the type of treatment, the specific drug or approach used, and the individual patient's response. Here are some common potential side effects of immunotherapy:
1. Immune-Related Adverse Events (irAEs): These are side effects caused by the overactivation of the immune system. They can affect various organs and systems in the body. Common irAEs include:
- Skin rashes and itching
- Fatigue
- Diarrhea or colitis
- Liver inflammation (hepatitis)
- Thyroid problems (hypothyroidism or hyperthyroidism)
- Pneumonitis (lung inflammation)
- Endocrine disorders (e.g., adrenal insufficiency)
2. Flu-Like Symptoms: Some patients may experience symptoms similar to the flu, such as fever, chills, muscle aches, and fatigue.
3. Skin Reactions: Skin-related side effects can include rash, itching, and in some cases, more severe reactions like blistering and peeling.
4. Gastrointestinal Issues: Immunotherapy can lead to digestive problems, including diarrhea, nausea, vomiting, and loss of appetite.
5. Fatigue: Many patients undergoing immunotherapy may experience increased fatigue.
6. Pneumonitis: Inflammation of the lungs (pneumonitis) can cause symptoms like cough, shortness of breath, and chest pain.
7. Endocrine Disorders: Some immunotherapies can affect the endocrine system, leading to hormone imbalances and related symptoms.
8. Infusion Reactions: During the infusion of certain immunotherapy drugs, patients may experience symptoms like fever, chills, or low blood pressure.
9. Changes in Blood Counts: Immunotherapy can sometimes lead to changes in blood cell counts, including a decrease in white blood cells, which can increase the risk of infections.
10. Cardiovascular Side Effects: In rare cases, certain immunotherapies may lead to heart problems.
It's important to note that while these side effects can occur, not all patients will experience them, and the severity can vary widely. Additionally, many side effects can be managed and treated effectively by healthcare providers. Prompt reporting of side effects to your healthcare team is crucial, as early intervention can help mitigate these issues.
Patients undergoing immunotherapy should have regular follow-up appointments and close communication with their healthcare providers to monitor for and address any side effects. The potential benefits of immunotherapy in treating cancer and autoimmune diseases often outweigh the risks of side effects, but the decision to use immunotherapy and manage side effects should be individualized and closely monitored for each patient.