COVID: A Reminder To Stay Safe

COVID: A reminder to stay safe

As we approach the second wave of COVID, we need to remain vigilant with our actions to prevent the spread of the virus. We are continuously reminded about wearing a mask in public, maintaining socially distant, and not engaging in risky behavior such as large gatherings. But today we will focus on other forms of transmission. COVID is primarily transmitted by airborne droplets, but spreading the infection through infected surfaces is still feasible. Here we will look at three articles that investigate this mode of transmission.

SARS-COV-2 Survives for 28 days on surfaces

This study by Australian scientists has found that SARS-CoV-2 can survive on surfaces for up to 28 days. The team investigated using the same amounts of virus found on infected individuals, interacting with surfaces such as cotton, paper, stainless steel, glass, and vinyl. Such materials were chosen as they represent commonly touched objects such as mobile phones, ATMs, supermarket checkout regions, items that may not be cleaned regularly enough. Previous research showed the virus could be detected in aerosols for up to three hours, and on plastic and stainless steel surfaces for up to three days.

This study found the virus may survive as long as a week on most surfaces, with enough potency to re-infect. Even after two weeks, there were still plenty of detectable viruses. On other surfaces such as banknotes, the virus could survive as long as a month. The survival of the virus is also potentiated by colder temperatures. The virus is far less likely to survive at 30C than at 6 C, a worrying finding for countries currently approaching winter.

Survival of SARS-CoV 2 on the human skin

We know our skin is host to millions of different bacteria and viruses, but the conditions created by the body alongside the degree of microbial competition actually makes it quite a hostile environment for pathogenic microbes. Hirose et al looked to investigate how well the SARS-CoV-2 virus survives on human skin, using a model. They found that SARS-CoV-2 and the influenza A virus were destroyed more quickly on the skin than other surfaces such as steel, glass, and plastic. However, COVID lasted over 4x longer on skin compared to Influenza A (9 hours vs 1.8 hours).

More importantly, ethanol compounds were found to inactivate SARS-CoV-2 within 15 seconds on human skin. This highlights the importance of regular hand washing, even if with alcohol gel. Taking this in mind, it is useful to keep small bottles of alcohol gel on a person when traveling in public and using it regularly. After all, if you are touching door handles and other items that hundreds of other people may have touched before you, potentially with poor hygiene, it is safer to regularly disinfect.

Low risk of COVID transmission by fomites in real life conditions

Having taken these studies into account, it is quite difficult to quantifiably measure transmission from surface to a person. Knowledge of this transmissibility is quite important, especially to those working in a hospital environment. A review by Mondelli et al published in the prestigious journal The Lancet (Infectious Disease) describes two sequential studies to looking at the possibility of contamination of surfaces in an infectious disease ward of a major Italian hospital, and also whether risk of transmission was higher in emergency rooms and sub-intensive care wards.

These studies found there were very few surfaces in the hospital through which positive swabs could be taken, suggesting contamination was low. Of course the hospitals were running standard cleaning procedures, with regular wipedowns of commonly toughed objects. This again highlights the importance of maintaining hygiene, and how adequate cleanliness can significantly reduce the risk of infection.

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Guillain-Barre syndrome - Symptoms and causes

Guillain-Barré syndrome (GBS) is a rare but serious neurological condition in which the body’s immune system mistakenly attacks the peripheral nervous system. This condition can lead to muscle weakness, numbness, and even paralysis in severe cases. Understanding Guillain-Barré syndrome symptoms, causes, and treatment options is crucial for early detection and effective management.

Guillain-Barré Syndrome Symptoms

The symptoms of Guillain-Barré syndrome typically begin with mild sensations of tingling or numbness in the hands and feet. These early signs of Guillain-Barré syndrome may quickly progress to more severe issues, including:

Muscle Weakness: Starting in the legs and spreading to the upper body, this weakness can become so severe that mobility is significantly impaired.
Reflex Loss: Deep tendon reflexes, such as the knee-jerk response, are often diminished or absent.
Pain: Many individuals experience sharp or cramping pain, particularly in the lower back.
Difficulty with Eye or Facial Movements: Symptoms may include difficulty speaking, chewing, or swallowing.
Respiratory Problems: In some cases, Guillain-Barré syndrome and respiratory failure become significant concerns, necessitating immediate medical intervention.
Autonomic Dysfunction: Irregular heart rhythms, blood pressure fluctuations, and other involuntary functions can be affected.

Guillain-Barré Syndrome Causes

The exact causes of Guillain-Barré syndrome are not fully understood. However, it is widely believed that the syndrome is triggered by an overactive immune response to an infection or other environmental factors. Common Guillain-Barré syndrome causes and risk factors include:

Viral Infections: Conditions such as influenza, Zika virus, and Epstein-Barr virus have been associated with GBS.
Bacterial Infections: Campylobacter jejuni, a bacterium often linked to food poisoning, is a common trigger.
Vaccinations: Although extremely rare, certain vaccines have been linked to GBS.
Surgical Procedures: Some individuals may develop Guillain-Barré syndrome following surgery.
Other Risk Factors: A history of autoimmune disorders or genetic predispositions may increase the risk.

Guillain-Barré Syndrome Progression Stages

Guillain-Barré syndrome progression stages typically unfold in three distinct phases:

Initial Stage: Lasting 1-4 weeks, this stage includes the rapid onset of Guillain-Barré syndrome symptoms such as weakness and numbness.
Plateau Stage: Symptoms stabilize but remain severe. This stage can last several weeks.
Recovery Stage: Gradual improvement begins, although Guillain-Barré syndrome recovery time can vary significantly between individuals, often taking weeks to months.

Guillain-Barré Syndrome Diagnosis

Diagnosing Guillain-Barré syndrome requires a thorough clinical evaluation. Physicians rely on specific Guillain-Barré syndrome diagnosis criteria, which include:

Patient History: Recent infections or medical procedures may provide crucial clues.
Neurological Examination: Reflexes, muscle strength, and sensory responses are assessed.
Electrodiagnostic Tests: Nerve conduction studies (NCS) and electromyography (EMG) help identify nerve damage.
Lumbar Puncture: Testing cerebrospinal fluid (CSF) can reveal elevated protein levels, a hallmark of GBS.

Early diagnosis is essential for effective treatment and to prevent complications like Guillain-Barré syndrome and respiratory failure.

Guillain-Barré Syndrome Treatment

Treatment for Guillain-Barré syndrome focuses on managing symptoms and speeding up recovery. The primary Guillain-Barré syndrome treatment options include:

Plasma Exchange (Plasmapheresis): This procedure removes harmful antibodies from the blood.
Intravenous Immunoglobulin (IVIG): High-dose immunoglobulin therapy helps neutralize the antibodies attacking the nervous system.
Supportive Care: Ventilatory support may be needed in severe cases, along with physical therapy to aid rehabilitation.

Guillain-Barré Syndrome Prognosis

The prognosis for Guillain-Barré syndrome varies depending on the severity of the condition and the timeliness of treatment. While most individuals recover fully, Guillain-Barré syndrome prognosis can include long-term complications such as:

Persistent Weakness: Some patients may experience lingering muscle weakness.
Nerve Damage: Chronic nerve pain or numbness can occur in rare cases.
Recurrence: Although uncommon, some individuals may develop Guillain-Barré syndrome again.

Guillain-Barré Syndrome Recovery Time

Guillain-Barré syndrome recovery time can range from a few weeks to several months. Factors that influence recovery include:

Age: Younger individuals generally recover faster.
Severity: Severe cases with extensive nerve damage may take longer to heal.
Timely Treatment: Early intervention is key to minimizing long-term effects and shortening recovery time.

Conclusion

Guillain-Barré syndrome is a challenging condition that requires early recognition and prompt treatment. By understanding the symptoms, causes, and treatment options, individuals can better manage this syndrome and improve their outcomes. If you or a loved one suspect Guillain-Barré syndrome, consult a healthcare professional immediately. Early diagnosis and treatment are critical for a full recovery.