Asymptomatic Carriers Of COVID

Why Asymptomatic carriers of COVID are as dangerous as symptomatic patients

Many countries have now begun enforcing masks for everyone to wear when out in public, in enclosed spaces, or on public transport. There is good evidence to support these measures, but unfortunately, some still show resistance to the idea. Whilst some reasons put forward are non-sensical (masks do not cause any noticeable or measurable decrease in oxygen delivery to the body), other people feel like they shouldn’t wear a mask because they do not have symptoms of COVID. And thus would not spread anything. Here we look at a recent publication in Nature, one of the most esteemed peer-reviewed scientific journals in the world, and what it shows us about the transmission of COVID in a population.

This study by Lavezzo et al looked at the suppression of the SARS-CoV-2 outbreak in the Italian municipality of Vo’. This municipality is 50 kilometers west of Venice with a population of just 3,416 people. It experienced its first casualty of COVID on the 21st of February, after which it underwent lockdown for 14 days. During this time data was collected on the clinical presentation and hospitalization of COVID patients, as well as other citizens through the contact tracing network.

In total 2,812 residents were tested in late February, with another 2,343 tests performed two weeks later at the end of lockdown. Nasal and throat swabs were taken to identify infected individuals. The study found only 2.6% of people were positive for COVID at the start of lockdown, which reduced to 1.2% two weeks later.

Out of this infected population, 42.5% were asymptomatic. They had no symptoms at the time of swab testing nor did they develop symptoms afterwards. When the viral load was measured between symptomatic and asymptomatic patients, there was little difference.

Evidence has pointed to a large asymptomatic population, and previous studies have shown it to be as high as 50% in some cases. Many would assume if a patient has no symptoms then they must have fought the infection before it became an issue, or had a very low viral load and therefore were not likely to spread it. This study shows it is simply not true. Asymptomatic carriers of COVID are likely to contribute to the transmission and spread of COVID amongst the population.

If you are asymptomatic you have as high a viral load as someone who is symptomatic. But there is no way to tell without a swab. You have as much of a potential to spread the infection to the vulnerable. Even in people who became symptomatic the height of transmission was found to be before the patient showed any symptoms.

So what does this mean? If you have COVID you are likely to spread it before you show any symptoms or any symptoms at all. We know masks are effective at significantly reducing the spread of COVID, by catching the water droplets that carry the SARS-CoV-2 Virus. Now that shops and public places are re-opening, the risk of spread is high.

Wear a mask. Stop the spread.

https://www.nature.com/articles/s41586-020-2488-1_reference.pdf suppression of a SARS article

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Guillain-Barre syndrome - Symptoms and causes

Guillain-Barré syndrome (GBS) is a rare but serious neurological condition in which the body’s immune system mistakenly attacks the peripheral nervous system. This condition can lead to muscle weakness, numbness, and even paralysis in severe cases. Understanding Guillain-Barré syndrome symptoms, causes, and treatment options is crucial for early detection and effective management.

Guillain-Barré Syndrome Symptoms

The symptoms of Guillain-Barré syndrome typically begin with mild sensations of tingling or numbness in the hands and feet. These early signs of Guillain-Barré syndrome may quickly progress to more severe issues, including:

Muscle Weakness: Starting in the legs and spreading to the upper body, this weakness can become so severe that mobility is significantly impaired.
Reflex Loss: Deep tendon reflexes, such as the knee-jerk response, are often diminished or absent.
Pain: Many individuals experience sharp or cramping pain, particularly in the lower back.
Difficulty with Eye or Facial Movements: Symptoms may include difficulty speaking, chewing, or swallowing.
Respiratory Problems: In some cases, Guillain-Barré syndrome and respiratory failure become significant concerns, necessitating immediate medical intervention.
Autonomic Dysfunction: Irregular heart rhythms, blood pressure fluctuations, and other involuntary functions can be affected.

Guillain-Barré Syndrome Causes

The exact causes of Guillain-Barré syndrome are not fully understood. However, it is widely believed that the syndrome is triggered by an overactive immune response to an infection or other environmental factors. Common Guillain-Barré syndrome causes and risk factors include:

Viral Infections: Conditions such as influenza, Zika virus, and Epstein-Barr virus have been associated with GBS.
Bacterial Infections: Campylobacter jejuni, a bacterium often linked to food poisoning, is a common trigger.
Vaccinations: Although extremely rare, certain vaccines have been linked to GBS.
Surgical Procedures: Some individuals may develop Guillain-Barré syndrome following surgery.
Other Risk Factors: A history of autoimmune disorders or genetic predispositions may increase the risk.

Guillain-Barré Syndrome Progression Stages

Guillain-Barré syndrome progression stages typically unfold in three distinct phases:

Initial Stage: Lasting 1-4 weeks, this stage includes the rapid onset of Guillain-Barré syndrome symptoms such as weakness and numbness.
Plateau Stage: Symptoms stabilize but remain severe. This stage can last several weeks.
Recovery Stage: Gradual improvement begins, although Guillain-Barré syndrome recovery time can vary significantly between individuals, often taking weeks to months.

Guillain-Barré Syndrome Diagnosis

Diagnosing Guillain-Barré syndrome requires a thorough clinical evaluation. Physicians rely on specific Guillain-Barré syndrome diagnosis criteria, which include:

Patient History: Recent infections or medical procedures may provide crucial clues.
Neurological Examination: Reflexes, muscle strength, and sensory responses are assessed.
Electrodiagnostic Tests: Nerve conduction studies (NCS) and electromyography (EMG) help identify nerve damage.
Lumbar Puncture: Testing cerebrospinal fluid (CSF) can reveal elevated protein levels, a hallmark of GBS.

Early diagnosis is essential for effective treatment and to prevent complications like Guillain-Barré syndrome and respiratory failure.

Guillain-Barré Syndrome Treatment

Treatment for Guillain-Barré syndrome focuses on managing symptoms and speeding up recovery. The primary Guillain-Barré syndrome treatment options include:

Plasma Exchange (Plasmapheresis): This procedure removes harmful antibodies from the blood.
Intravenous Immunoglobulin (IVIG): High-dose immunoglobulin therapy helps neutralize the antibodies attacking the nervous system.
Supportive Care: Ventilatory support may be needed in severe cases, along with physical therapy to aid rehabilitation.

Guillain-Barré Syndrome Prognosis

The prognosis for Guillain-Barré syndrome varies depending on the severity of the condition and the timeliness of treatment. While most individuals recover fully, Guillain-Barré syndrome prognosis can include long-term complications such as:

Persistent Weakness: Some patients may experience lingering muscle weakness.
Nerve Damage: Chronic nerve pain or numbness can occur in rare cases.
Recurrence: Although uncommon, some individuals may develop Guillain-Barré syndrome again.

Guillain-Barré Syndrome Recovery Time

Guillain-Barré syndrome recovery time can range from a few weeks to several months. Factors that influence recovery include:

Age: Younger individuals generally recover faster.
Severity: Severe cases with extensive nerve damage may take longer to heal.
Timely Treatment: Early intervention is key to minimizing long-term effects and shortening recovery time.

Conclusion

Guillain-Barré syndrome is a challenging condition that requires early recognition and prompt treatment. By understanding the symptoms, causes, and treatment options, individuals can better manage this syndrome and improve their outcomes. If you or a loved one suspect Guillain-Barré syndrome, consult a healthcare professional immediately. Early diagnosis and treatment are critical for a full recovery.