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Published on: May 22, 2020
1 minute read
By: Dr Rajan Choudhary

Corona Virus In Young Patients And Kids

Kids seem to be relatively unaffected by COVID, but this does not mean they are invulnerable. As with adults, some children have pre-existing cardiac, respiratory, or metabolic conditions, and are therefore more vulnerable to the effects of COVID. Interestingly, children appear to have one more symptom when infected with coronavirus – COVID Toes.

I personally came across this phenomenon recently, with a young patient asymptomatic for COVID who presented with unusual symptoms of dark bruises on his toes. This had been present for just a few days. He did not have any pain, itching, swelling, no recent trauma, or injury to the feet. Circulation to his feet was normal, with no other rashes or skin changes, no other abnormal features in the history to note. It was certainly an odd presentation and certainly could have been an example of COVID toes.

This new phenomenon was noticed in April and has not gained as much notoriety because it is fairly rare compared to the major COVID symptoms, such as fever, cough, and lethargy. Doctors have described lesions on the feet of young people, usually purple-colored, around the tips of the toes. They have been compared to chilblains, painful swellings on feet, and toes that appear in the cold. Similarly to chilblains they do not cause any permanent damage and usually regress in days to weeks.

It's not clear why they occur or the mechanism behind the discoloration, because the presentation is rare and in healthy patients. We know COVID can cause systemic inflammation and can increase the risk of clot formation. It may be that localized inflammation is occurring in the toes, causing the vessels to clamp down and reduce blood flow to the area. This is similar to the mechanism for chilblains forming in the foot. Micro-clotting could also be partially responsible for this phenomenon.

COVID Toes is not the only skin symptoms related to COVID. In a paper published in the British Journal of Dermatology, researchers described five common skin presentations in 375 COVID patients. These were:

Asymmetrical chilblain like lesions in the hands and feet, found in younger patients lasting up to 2 weeks.
Small itchy blisters in the trunk and limbs, found in middle-aged patients before they present with symptoms, lasting about 10 days
Pink or white areas of raised skin, itchy, usually on the body
Raised bumps called macropapules, lasting about a week, seen in more severe infections.
Mottled, blotchy red-blue skin (known as livedo) seen in patients with severe illness.

So if you are currently suffering from COVID or have recently recovered from an infection, and suddenly notice odd colored toes, you too may have a case of COVID toes.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Genetic Predisposition Testing India: Understanding Your DNA to Prevent Future Disease

Genetics plays a significant role in determining an individual’s risk for various diseases. In India, where chronic illnesses like diabetes, heart disease, cancer, and neurological disorders are increasing rapidly, genetic predisposition testing has emerged as a powerful preventive tool. It helps individuals understand inherited risk factors long before symptoms appear, allowing timely intervention.

SecondMedic offers guided genetic screening to help patients uncover DNA-based risks and take proactive control of their long-term health.

What Is Genetic Predisposition Testing?

Genetic predisposition testing analyzes a person’s DNA to identify mutations, variations, or inherited markers associated with increased disease risk. It does not diagnose a disease but reveals how likely an individual is to develop certain conditions.

What the test identifies:

Gene mutations
Family-linked disease patterns
Hereditary cancer markers
Metabolic and cardiovascular risks
Neurological conditions
Autoimmune predispositions

These insights help individuals and doctors make informed preventive health decisions.

Why Genetic Testing Is Growing in India

1. High prevalence of lifestyle and hereditary diseases

India is the diabetes capital of the world, and many metabolic disorders have genetic roots.

2. Increasing cancer burden

BRCA and other hereditary cancer syndromes are being detected more often.

3. Awareness about preventive healthcare

People want to act early rather than wait for disease onset.

4. Growth of digital healthcare

Easy access through telemedicine platforms like SecondMedic.

5. Rising chronic cases at younger ages

Genetic predispositions often accelerate early onset of disease.

What Diseases Can Genetic Testing Predict?

1. Cancer Risk

Includes hereditary cancers such as:

Breast
Ovarian
Colorectal
Prostate
Pancreatic

BRCA1, BRCA2, and Lynch syndrome genes are key markers.

2. Heart Disease & Hypertension

Genes that influence:

Cholesterol levels
Plaque formation
Blood pressure regulation

3. Diabetes

Genes that affect insulin sensitivity and metabolic function.

4. Obesity

Markers linked to appetite regulation and fat storage.

5. Neurological Disorders

Including Alzheimer’s, Parkinson’s, and epilepsy predispositions.

6. Autoimmune Diseases

Genes related to lupus, rheumatoid arthritis, and thyroid disorders.

7. Drug Response (Pharmacogenomics)

DNA determines how the body reacts to certain medications.

How Genetic Predisposition Testing Works

Step 1: Sample Collection

Usually saliva, blood, or buccal swab.

Step 2: DNA Sequencing

Advanced technology identifies variations in your genome.

Step 3: Risk Analysis

Gene mutations are mapped to known disease risks.

Step 4: Expert Interpretation

SecondMedic’s genetic counsellors and doctors review results.

Step 5: Preventive Plan

Includes recommended lifestyle changes, screenings, and monitoring.

Benefits of Genetic Predisposition Testing

1. Detect Risk Before Symptoms

Allows decades of preventive action.

2. Personalized Health Planning

Diet, exercise, and medical screening tailored to DNA.

3. Early Cancer Detection

Essential for women with hereditary breast/ovarian cancer risk.

4. Family Health Insights

Identifies conditions that may affect children and siblings.

5. Improved Treatment Outcomes

Knowing your risk helps doctors monitor you more closely.

6. Better Drug Selection

Pharmacogenomics ensures medications match your genetic profile.

Who Should Consider Genetic Testing?

People with family history of cancer
Individuals whose relatives had early heart attacks
Families with diabetes across generations
Women with breast or ovarian cancer history
Couples planning pregnancy
People with unexplained chronic conditions
Individuals wanting personalized preventive healthcare

Limitations of Genetic Testing

1. Not a diagnosis

It shows probability, not certainty.

2. Environmental and lifestyle factors still matter

Genes interact with habits and environment.

3. Requires professional interpretation

Raw results without counselling can be confusing.

SecondMedic ensures accurate guidance through experienced specialists.

How SecondMedic Supports Genetic Testing

1. End-to-End Genetic Screening

From sample collection to detailed analysis.

2. Expert Review

Genetic counselors and doctors explain every risk factor.

3. Personalized Preventive Plan

Nutrition, exercise, and screening based on DNA.

4. Confidential Reporting

All data is securely stored.

5. Integrated Preventive Tracking

Follow-up tests and monitoring for high-risk individuals.

Future of Genetic Testing in India

AI-based genome interpretation
Affordable whole-genome sequencing
Predictive analytics for early cancer
Family-wide health risk mapping
Integration with digital health IDs under ABDM

SecondMedic aims to make genetic screening widely accessible and scientifically guided.

Conclusion

Genetic predisposition testing India empowers individuals by revealing inherited disease risks long before symptoms develop. It supports preventive healthcare, early cancer detection, and personalized wellness planning. With platforms like SecondMedic offering expert-guided genetic testing, Indians can now take proactive control of their long-term health.

To book your genetic test, visit www.secondmedic.com

References

ICMR – Genetic research insights
NIH – Genetic testing guidelines
WHO – Genomic medicine developments
Statista – DNA testing market India
SecondMedic genetic health studies

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