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Published on: Apr 04, 2020
3 minute read
By: Dr Rajan Choudhary

Developing A Vaccine For COVID-19? Part 1

It is often stated vaccination has made the greatest contribution to global health of any human discovery, other than clean water and sanitation, and their impact on everyday life is immediately evident. We have managed to completely eradicate two major infections from existence (smallpox and rinderpest) , and the WHO are working towards adding polio to that list.

In these cases the numbers speak for themselves. It is estimated that the eradication of smallpox in 1980 has saved 5 million lives per year, adding up to 150 to 200 million by 2018. Common vaccination programmes for polio, measles, mumps, rubella, rabies and hepatitis A have prevented nearly 200 million cases from occurring in the US alone over the past 50 years, and 4.5 billion instances of the diseases worldwide.

We have achieved a 99% immunisation rate against polio, preventing children from suffering crippling paralysis, and only 3 countries remain. Sadly, around 1.4 million children under 5 still die from preventable diseases each year as they do not have access to these life saving vaccines, but charities and public health organisations around the world are working hard to improve access.

So what are vaccines? And how will they help is in the face of the latest pandemic? Here we will go into the challenges behind making vaccines, and why a vaccine against COVID-19 is unlikely to be ready in the next few months, or even this year.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024226/ contribution of vaccination

https://www.who.int/features/factfiles/polio/en/ polio eradication

https://www.sciencedaily.com/releases/2017/03/170303163208.htm study article

WHAT IS A VACCINE

The human body’s immune system is incredibly smart. It is able to distinguish between infective organisms, such as bacteria, viruses and parasites, from our own body’s cells, target these invaders for destruction and keep our bodies healthy. Even better, the body remembers any previous infections it has had before, recognise these previous infections even quicker and even eradicate the disease before we know we are infected.

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In summary, medicines treat us when we get an infection. Vaccines make sure we never suffer from an infection in the first place.

https://www.chop.edu/centers-programs/vaccine-education-center/making-vaccines/how-are-vaccines-made Making Vaccines

THE HURDLES WE FACE IN RESEARCH

Making a vaccine is a difficult process, one that can take 3–5 years and cost hundreds of millions of dollars, sometimes billions of dollars. This is because there are many difficult steps to be taken in the process of creating a vaccine that is effective, but more importantly one that is safe.

To start with the troubling organism has to be identified. For COVID-19 it took a few weeks to recognise the virus responsible, and some time more to understand its genetic code and grow the virus in lab conditions. We then have to understand the virus, how it infects, how it causes symptoms, and how it has mutated compared to the coronaviruses responsible for SARS and MERS.

After this, we have to isolate parts of the virus our immune system will recognise. This is usually the outside coat of the virus. The DNA responsible for making these parts need to be found in the virus’ genetic code, and put inside other “skeleton” viruses. This will force the dummy virus to look like coronavirus, without the ability to infect and kill someone.

These dummy viruses can be injected into animals to see if it causes an immune reaction, whether the immune system recognises it as the coronavirus responsible for COVID-19, and whether it will protect the animal from the real COVID-19. Up to now the research has likely cost a few million dollars. The next step is when the price inflates up to billions.

If the vaccine appears safe in animals, it can be tested in humans. This can be dangerous at first, since we don’t know whether a vaccine that works in an animal will work in a human. And we don’t know if there will be any side effects to the vaccine. Human testing has to be very thorough, very careful, and safe for use. If you give too much of the virus it might make the person sick, too little and it wont immunise the person. These clinical trials can take years, and if the vaccine fails at this point its back to the drawing board, to try another step.

https://www.theatlantic.com/politics/archive/2014/10/how-to-make-an-ebola-vaccine-5-simplified-steps/454443/ ebola vaccine

Now we have a basic understanding of what vaccines are and why it takes so long to make a vaccine. In the next part we will look at why viral vaccines can cause even more problems, and how far we have come with the COVID-19 vaccine,

Dr Rajan Choudhary, London UK

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5K Run for a Cause: How Community Fitness Drives Preventive Health Awareness

Physical activity is one of the most effective tools for disease prevention, yet it remains underutilised in everyday life. Community-based fitness initiatives such as a 5K Run for a Cause play a powerful role in bridging this gap by making movement accessible, meaningful and socially engaging. These events combine the benefits of exercise with awareness-building, creating lasting impact on public health.

In India, lifestyle-related diseases such as diabetes, heart disease and obesity are rising rapidly. According to the Indian Council of Medical Research (ICMR) and National Family Health Survey (NFHS-5), physical inactivity is a major contributor to this growing burden. Events that encourage structured, enjoyable physical activity help counter this trend.

What Is a 5K Run for a Cause?

A 5K Run for a Cause is a short-distance running or walking event designed to promote fitness while supporting a health, social or community objective. Participants may run, jog or walk the 5-kilometre distance, making the event inclusive for people of varying fitness levels.

Beyond physical activity, these runs aim to:

raise awareness about preventive health
encourage active lifestyles
build community participation
support wellness-driven causes

Why 5K Is an Ideal Distance

The 5-kilometre distance is widely recognised as:

achievable for beginners
challenging enough to promote fitness
safe for most age groups with minimal training

WHO physical activity guidelines support moderate-intensity exercise like running or brisk walking for improving cardiovascular and metabolic health.

Health Benefits of Participating in a 5K Run

Improved Cardiovascular Health

Running and brisk walking strengthen the heart, improve circulation and lower blood pressure. Regular participation reduces the risk of heart disease and stroke.

Better Metabolic Health

Physical activity improves insulin sensitivity and supports weight management. ICMR data shows that regular movement significantly reduces diabetes risk.

Enhanced Mental Wellbeing

Exercise releases endorphins that reduce stress, anxiety and depression. Community runs add a social element that further supports mental health.

Improved Musculoskeletal Strength

Running strengthens muscles, bones and joints, reducing the risk of age-related mobility issues.

Role of 5K Runs in Preventive Healthcare

Preventive healthcare focuses on reducing disease risk before illness develops. A 5K Run for a Cause supports prevention by:

promoting physical activity
encouraging regular movement habits
raising awareness about lifestyle diseases
motivating health-conscious behaviour

NITI Aayog identifies physical activity promotion as a key pillar of preventive healthcare in India.

Community Impact of a 5K Run for a Cause

Building Health Awareness

Runs often highlight specific causes such as heart health, diabetes prevention or mental wellbeing, reinforcing public health messages.

Strengthening Social Bonds

Community participation fosters shared goals and mutual motivation, increasing long-term adherence to healthy habits.

Encouraging Family Participation

Inclusive events encourage families to adopt healthier lifestyles together.

5K Runs and Corporate Wellness Programs

Corporate wellness programs increasingly include physical activity initiatives.

Benefits for organisations include:

improved employee engagement
reduced absenteeism
enhanced team bonding
positive employer branding

EY-FICCI reports show that wellness initiatives focused on physical activity deliver strong participation and measurable health benefits.

Accessibility and Inclusivity

A key strength of 5K runs is inclusivity.

They accommodate:

first-time runners
walkers
older adults
people transitioning to active lifestyles

This inclusiveness reduces barriers to participation.

Supporting Long-Term Behaviour Change

One-time events create awareness, but their true value lies in inspiring long-term change.

Participants often:

continue walking or running regularly
become more conscious of fitness
seek preventive health checkups

Lancet studies indicate that community-based physical activity initiatives can influence long-term health behaviours.

Safety and Health Considerations

For safe participation:

individuals should assess fitness levels
warm-up and cool-down are essential
hydration should be prioritised
those with medical conditions should seek medical advice

Proper guidance ensures benefits without injury.

Role of Awareness and Education

Successful runs integrate education through:

health talks
informational materials
screening camps
wellness resources

This combination reinforces preventive health messages.

Measuring Impact

Impact can be assessed through:

participation rates
follow-up health initiatives
employee engagement metrics
community feedback

Data-driven evaluation improves future program design.

Why 5K Runs Matter in India

India faces challenges such as:

rising sedentary lifestyles
limited health awareness
increasing chronic disease burden

Community fitness events provide a scalable, low-cost solution to promote active living and prevention.

Conclusion

A 5K Run for a Cause is more than a fitness event—it is a preventive health movement. By combining physical activity with purpose, these runs encourage healthier lifestyles, strengthen community bonds and raise awareness about long-term wellbeing. In a country where lifestyle diseases are growing rapidly, initiatives that make movement accessible and meaningful are essential. A simple 5K run can be a powerful step toward a healthier, more active society.

References

ICMR – Physical Activity and Lifestyle Disease Prevention Reports
National Family Health Survey (NFHS-5) – Physical Activity and Health Data
NITI Aayog – Preventive Healthcare and Physical Activity Promotion Strategy
WHO – Physical Activity and Health Guideline
Lancet – Community Fitness and Preventive Health Studies
Statista – Fitness Events and Participation Trends India
EY-FICCI – Corporate Wellness and Physical Activity Reports

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