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Published on: Apr 04, 2020
3 minute read
By: Dr Rajan Choudhary

Developing A Vaccine For COVID-19? Part 1

It is often stated vaccination has made the greatest contribution to global health of any human discovery, other than clean water and sanitation, and their impact on everyday life is immediately evident. We have managed to completely eradicate two major infections from existence (smallpox and rinderpest) , and the WHO are working towards adding polio to that list.

In these cases the numbers speak for themselves. It is estimated that the eradication of smallpox in 1980 has saved 5 million lives per year, adding up to 150 to 200 million by 2018. Common vaccination programmes for polio, measles, mumps, rubella, rabies and hepatitis A have prevented nearly 200 million cases from occurring in the US alone over the past 50 years, and 4.5 billion instances of the diseases worldwide.

We have achieved a 99% immunisation rate against polio, preventing children from suffering crippling paralysis, and only 3 countries remain. Sadly, around 1.4 million children under 5 still die from preventable diseases each year as they do not have access to these life saving vaccines, but charities and public health organisations around the world are working hard to improve access.

So what are vaccines? And how will they help is in the face of the latest pandemic? Here we will go into the challenges behind making vaccines, and why a vaccine against COVID-19 is unlikely to be ready in the next few months, or even this year.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024226/ contribution of vaccination

https://www.who.int/features/factfiles/polio/en/ polio eradication

https://www.sciencedaily.com/releases/2017/03/170303163208.htm study article

WHAT IS A VACCINE

The human body’s immune system is incredibly smart. It is able to distinguish between infective organisms, such as bacteria, viruses and parasites, from our own body’s cells, target these invaders for destruction and keep our bodies healthy. Even better, the body remembers any previous infections it has had before, recognise these previous infections even quicker and even eradicate the disease before we know we are infected.

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In summary, medicines treat us when we get an infection. Vaccines make sure we never suffer from an infection in the first place.

https://www.chop.edu/centers-programs/vaccine-education-center/making-vaccines/how-are-vaccines-made Making Vaccines

THE HURDLES WE FACE IN RESEARCH

Making a vaccine is a difficult process, one that can take 3–5 years and cost hundreds of millions of dollars, sometimes billions of dollars. This is because there are many difficult steps to be taken in the process of creating a vaccine that is effective, but more importantly one that is safe.

To start with the troubling organism has to be identified. For COVID-19 it took a few weeks to recognise the virus responsible, and some time more to understand its genetic code and grow the virus in lab conditions. We then have to understand the virus, how it infects, how it causes symptoms, and how it has mutated compared to the coronaviruses responsible for SARS and MERS.

After this, we have to isolate parts of the virus our immune system will recognise. This is usually the outside coat of the virus. The DNA responsible for making these parts need to be found in the virus’ genetic code, and put inside other “skeleton” viruses. This will force the dummy virus to look like coronavirus, without the ability to infect and kill someone.

These dummy viruses can be injected into animals to see if it causes an immune reaction, whether the immune system recognises it as the coronavirus responsible for COVID-19, and whether it will protect the animal from the real COVID-19. Up to now the research has likely cost a few million dollars. The next step is when the price inflates up to billions.

If the vaccine appears safe in animals, it can be tested in humans. This can be dangerous at first, since we don’t know whether a vaccine that works in an animal will work in a human. And we don’t know if there will be any side effects to the vaccine. Human testing has to be very thorough, very careful, and safe for use. If you give too much of the virus it might make the person sick, too little and it wont immunise the person. These clinical trials can take years, and if the vaccine fails at this point its back to the drawing board, to try another step.

https://www.theatlantic.com/politics/archive/2014/10/how-to-make-an-ebola-vaccine-5-simplified-steps/454443/ ebola vaccine

Now we have a basic understanding of what vaccines are and why it takes so long to make a vaccine. In the next part we will look at why viral vaccines can cause even more problems, and how far we have come with the COVID-19 vaccine,

Dr Rajan Choudhary, London UK

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Diabetes Symptoms in Men: Early Warning Signs You Should Not Ignore

Diabetes is one of the fastest-growing health challenges worldwide, and men are particularly vulnerable to its long-term complications. In India, the burden of diabetes has increased sharply over the past two decades, driven by lifestyle changes, sedentary habits and dietary patterns. Despite this, many men remain unaware of early diabetes symptoms or delay medical consultation until complications develop.

Understanding diabetes symptoms in men is essential for early diagnosis, effective management and prevention of serious health consequences.

What Is Diabetes?

Diabetes is a chronic metabolic disorder characterised by high blood sugar levels due to:

insufficient insulin production
ineffective insulin action
or both

The most common form affecting men is type 2 diabetes, which is strongly linked to lifestyle factors.

Why Men Are at Higher Risk

Several factors increase diabetes risk in men:

higher abdominal fat accumulation
smoking and alcohol consumption
irregular eating patterns
work-related stress
lower healthcare-seeking behaviour

According to Indian Council of Medical Research data, a significant proportion of men remain undiagnosed until advanced stages.

Early Diabetes Symptoms in Men

Frequent Urination

Excess sugar in the blood causes kidneys to work harder, leading to increased urination, especially at night.

Excessive Thirst

Frequent urination leads to dehydration, causing constant thirst.

Fatigue and Weakness

Cells cannot utilise glucose efficiently, resulting in low energy levels and persistent tiredness.

Unexplained Weight Changes

Men may experience unexplained weight loss despite normal or increased appetite.

Increased Hunger

Insulin resistance prevents glucose from entering cells, triggering frequent hunger.

Diabetes Symptoms Unique or Commonly Seen in Men

Erectile Dysfunction

Diabetes damages blood vessels and nerves, leading to erectile dysfunction.

Studies show a strong association between diabetes and male sexual health problems.

Reduced Testosterone Levels

Men with diabetes often have lower testosterone, affecting libido, muscle mass and mood.

Decreased Muscle Strength

Poor glucose utilisation affects muscle health and physical stamina.

Skin and Infection-Related Symptoms

Slow-Healing Wounds

High blood sugar impairs wound healing, increasing infection risk.

Frequent Infections

Men with diabetes are more prone to:

skin infections
urinary tract infections
fungal infections

Vision and Nerve Symptoms

Blurred Vision

Fluctuating blood sugar affects eye lenses, causing blurred vision.

Tingling or Numbness

Nerve damage, known as diabetic neuropathy, causes tingling or numbness in hands and feet.

Why Diabetes Symptoms Are Often Ignored by Men

Many men dismiss symptoms as:

work-related fatigue
ageing
stress

This delay increases the risk of complications.

Long-Term Complications of Untreated Diabetes

If untreated, diabetes can lead to:

heart disease
kidney failure
nerve damage
vision loss
sexual dysfunction

According to WHO and Lancet studies, early detection significantly reduces complication risk.

Importance of Early Diagnosis

Early diagnosis allows:

better blood sugar control
lifestyle modification
prevention of organ damage

Routine screening is crucial, even in the absence of symptoms.

When Should Men Get Tested?

Men should consider testing if they:

are over 30 years old
have a family history of diabetes
are overweight
have a sedentary lifestyle
experience any warning signs

Annual screening is recommended for at-risk individuals.

Managing Diabetes After Diagnosis

Effective management includes:

healthy diet
regular physical activity
weight control
stress management
medical treatment as advised

Early management improves quality of life.

Role of Preventive Healthcare

Preventive healthcare focuses on:

early screening
lifestyle intervention
regular follow-up

According to NITI Aayog, preventive strategies are essential to control India’s diabetes burden.

Mental Health and Diabetes in Men

Diabetes can affect mental wellbeing, leading to:

stress
anxiety
depression

Addressing emotional health improves diabetes outcomes.

Breaking the Stigma Around Men’s Health

Men often avoid seeking help due to stigma.

Promoting awareness helps:

normalise health conversations
encourage timely medical care
reduce preventable complications

Conclusion

Diabetes symptoms in men often develop gradually and may go unnoticed for years. Frequent urination, fatigue, unexplained weight changes and sexual health issues should never be ignored. Early diagnosis and timely management significantly reduce the risk of serious complications and improve long-term health outcomes. Awareness, routine screening and proactive healthcare are essential steps for men to protect their health and wellbeing in an era of rising lifestyle diseases.

References

Indian Council of Medical Research (ICMR) – Diabetes Epidemiology and Risk Studies
World Health Organization (WHO) – Diabetes Prevention and Management Guidelines
National Family Health Survey (NFHS-5) – Diabetes Prevalence in Men
Lancet Diabetes & Endocrinology – Male-Specific Diabetes Outcomes
NITI Aayog – Non-Communicable Disease Prevention Reports
Statista – Global Diabetes Trends and Gender Differences

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