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Published on: Apr 04, 2020
3 minute read
By: Dr Rajan Choudhary

Developing A Vaccine For COVID-19? Part 1

It is often stated vaccination has made the greatest contribution to global health of any human discovery, other than clean water and sanitation, and their impact on everyday life is immediately evident. We have managed to completely eradicate two major infections from existence (smallpox and rinderpest) , and the WHO are working towards adding polio to that list.

In these cases the numbers speak for themselves. It is estimated that the eradication of smallpox in 1980 has saved 5 million lives per year, adding up to 150 to 200 million by 2018. Common vaccination programmes for polio, measles, mumps, rubella, rabies and hepatitis A have prevented nearly 200 million cases from occurring in the US alone over the past 50 years, and 4.5 billion instances of the diseases worldwide.

We have achieved a 99% immunisation rate against polio, preventing children from suffering crippling paralysis, and only 3 countries remain. Sadly, around 1.4 million children under 5 still die from preventable diseases each year as they do not have access to these life saving vaccines, but charities and public health organisations around the world are working hard to improve access.

So what are vaccines? And how will they help is in the face of the latest pandemic? Here we will go into the challenges behind making vaccines, and why a vaccine against COVID-19 is unlikely to be ready in the next few months, or even this year.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024226/ contribution of vaccination

https://www.who.int/features/factfiles/polio/en/ polio eradication

https://www.sciencedaily.com/releases/2017/03/170303163208.htm study article

WHAT IS A VACCINE

The human body’s immune system is incredibly smart. It is able to distinguish between infective organisms, such as bacteria, viruses and parasites, from our own body’s cells, target these invaders for destruction and keep our bodies healthy. Even better, the body remembers any previous infections it has had before, recognise these previous infections even quicker and even eradicate the disease before we know we are infected.

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In summary, medicines treat us when we get an infection. Vaccines make sure we never suffer from an infection in the first place.

https://www.chop.edu/centers-programs/vaccine-education-center/making-vaccines/how-are-vaccines-made Making Vaccines

THE HURDLES WE FACE IN RESEARCH

Making a vaccine is a difficult process, one that can take 3–5 years and cost hundreds of millions of dollars, sometimes billions of dollars. This is because there are many difficult steps to be taken in the process of creating a vaccine that is effective, but more importantly one that is safe.

To start with the troubling organism has to be identified. For COVID-19 it took a few weeks to recognise the virus responsible, and some time more to understand its genetic code and grow the virus in lab conditions. We then have to understand the virus, how it infects, how it causes symptoms, and how it has mutated compared to the coronaviruses responsible for SARS and MERS.

After this, we have to isolate parts of the virus our immune system will recognise. This is usually the outside coat of the virus. The DNA responsible for making these parts need to be found in the virus’ genetic code, and put inside other “skeleton” viruses. This will force the dummy virus to look like coronavirus, without the ability to infect and kill someone.

These dummy viruses can be injected into animals to see if it causes an immune reaction, whether the immune system recognises it as the coronavirus responsible for COVID-19, and whether it will protect the animal from the real COVID-19. Up to now the research has likely cost a few million dollars. The next step is when the price inflates up to billions.

If the vaccine appears safe in animals, it can be tested in humans. This can be dangerous at first, since we don’t know whether a vaccine that works in an animal will work in a human. And we don’t know if there will be any side effects to the vaccine. Human testing has to be very thorough, very careful, and safe for use. If you give too much of the virus it might make the person sick, too little and it wont immunise the person. These clinical trials can take years, and if the vaccine fails at this point its back to the drawing board, to try another step.

https://www.theatlantic.com/politics/archive/2014/10/how-to-make-an-ebola-vaccine-5-simplified-steps/454443/ ebola vaccine

Now we have a basic understanding of what vaccines are and why it takes so long to make a vaccine. In the next part we will look at why viral vaccines can cause even more problems, and how far we have come with the COVID-19 vaccine,

Dr Rajan Choudhary, London UK

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Zincovit Tablets: Uses, Benefits, Dosage, and Side Effects Explained

Nutritional deficiencies are common in India due to irregular diets, stress, fast-paced lifestyles and increased health demands. Multivitamin supplements are often recommended to support overall health, immunity and energy levels. One commonly prescribed supplement is Zincovit tablets.

This comprehensive guide explains what Zincovit is, its uses, benefits, dosage recommendations and potential side effects.

What Are Zincovit Tablets?

Zincovit is a multivitamin and multimineral supplement that contains:

Zinc
Vitamin C
B-complex vitamins
Vitamin A
Vitamin D
Vitamin E
Selenium and other antioxidants

It is commonly prescribed to address nutritional deficiencies and support immune function.

Uses of Zincovit Tablets

Zincovit may be recommended for:

1. Nutritional Deficiencies

Helps replenish low vitamin and mineral levels due to poor diet or illness.

2. Weak Immunity

Zinc and vitamin C support immune system function.

3. Recovery After Illness

Often prescribed during recovery from infections, surgery or prolonged weakness.

4. Fatigue and Low Energy

B vitamins help improve energy metabolism.

5. Hair and Skin Health

Zinc and antioxidants may support healthy skin and hair.

Benefits of Zincovit Tablets

Immune Support

Zinc plays a vital role in immune cell function.

Antioxidant Protection

Vitamins C and E help reduce oxidative stress.

Improved Energy Levels

B-complex vitamins aid in converting food into energy.

Better Nutritional Balance

Supports individuals with dietary gaps.

Support During Stress

Stress can deplete nutrients; supplementation may help maintain balance.

Recommended Dosage

Adults: Usually one tablet daily after meals
Children: Only if prescribed by a pediatrician
Duration: As advised by healthcare professional

Do not exceed recommended dosage without medical guidance.

How to Take Zincovit

Take after food to prevent stomach irritation
Swallow whole with water
Avoid taking with high-calcium foods unless advised

Consistency improves effectiveness.

Possible Side Effects

Zincovit is generally well tolerated. However, some individuals may experience:

Nausea
Mild stomach discomfort
Metallic taste
Constipation or diarrhea (rare)

Severe allergic reactions are uncommon but require immediate medical attention.

Who Should Use Caution?

Consult a doctor before taking Zincovit if you have:

Kidney disorders
Liver disease
Thyroid problems
Known allergies to supplement components

Pregnant and breastfeeding women should seek medical advice before use.

Can Zincovit Be Taken Long-Term?

Short-term use for deficiency correction is common. Long-term use should be monitored by a healthcare provider to avoid excessive intake of certain vitamins or minerals.

Excess zinc intake may interfere with copper absorption if taken excessively over time.

Zincovit and Immunity in India

With increasing concern about immunity and viral infections, supplements containing zinc and antioxidants have gained popularity. However, supplements should complement — not replace — a balanced diet rich in:

Fruits
Vegetables
Whole grains
Protein sources

Healthy lifestyle habits remain essential.

When to Consult a Doctor

Seek medical advice if you experience:

Persistent fatigue
Recurrent infections
Unexplained weight loss
Severe weakness

These may indicate underlying medical conditions beyond nutritional deficiency.

Balanced Nutrition Still Matters

Supplements cannot substitute a healthy diet. Combine Zincovit with:

Proper hydration
Regular exercise
Adequate sleep
Stress management

This ensures overall wellness.

Conclusion

Zincovit tablets are widely used multivitamin supplements that support immunity, energy levels and overall nutritional balance. When taken in recommended doses, they are generally safe and beneficial for individuals with dietary deficiencies or increased nutritional needs.

However, supplements should be used responsibly and under medical guidance, especially for long-term use. Maintaining a healthy diet and lifestyle remains the foundation of good health.

If you are unsure whether Zincovit is right for you, consult a healthcare professional for personalized advice.

References

Indian Council of Medical Research – Nutrient Guidelines
World Health Organization – Micronutrient Recommendations
National Health Portal India – Supplement Safety
Journal of Clinical Nutrition – Zinc and Immunity Studies
National Institute of Nutrition India – Dietary Guidelines

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