• Published on: Feb 06, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

Hibernation How Cancer Cells Utilise Strategies

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Hibernation – how cancer cells utilise strategies used by mice and bears to survive

Treatment of cancer can be split into two different categories – targeting and destroy rapidly dividing cells via chemo or radiotherapy, or target cells expressing cancer markers via immunotherapy. During treatment, the efficacy of chemo, radio or immunotherapy can be determined by looking at cancer biomarkers in the blood, or by re-scanning the patient to look at cancer activity. A reduction in these markers can give us assurances that the cancer is being treated, but this isn’t always the case. Recurrence or relapse is always an issue, and it is something we do not understand well.

Research so far has revealed that different types of cancer use different techniques to achieve dormancy and hide from the immune system. Some hide in fatty tissue, others achieve an equilibrium with the body’s immune system. Breast cancer cells have been found to undergo dormancy when exposed to some medications. This is similar to the hibernation state found in animals, and this is not just an apt metaphor.

The experiment looked at human colorectal cancer cells treated with chemotherapy. When exposed to chemotherapy agents, cancer cells were induced into a slow dividing state, able to survive with little nutrition. The gene expression of this state closely resembled that of mouse embryos when they undergo embryonic hibernation.

This embryonic hibernation is seen in over 100 types of mammals and is usually triggered when the mother is exposed to unfavourable environments when pregnant. Embryonic development is paused until a time when conditions become more favourable for pregnancy and birth. When entering hibernation, embryos undergo a cellular process called autophagy – where the cells essentially devour proteins inside the cell to survive. This same process was found in the dormant cancer cells, and when the autophagy mechanism was inhibited, the cancer cells failed to remain dormant and were ultimately destroyed by the chemotherapy.

This gives an interesting insight into how cancer cells utilise evolutionary strategy found in other mammals, intrinsic to our cellular makeup but not utilised by humans during reproduction, pregnancy or birth. Yet this conserved strategy provides cancer cells with another defence mechanism to survive against destruction by modern medicine. Understanding these mechanisms is key to improving the efficacy of our oncological treatment.

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Heart Related Health Issues: Early Warning Signs You Should Not Ignore

Heart related health issues remain one of the leading causes of illness and death worldwide. Despite advancements in medical care, many heart conditions are diagnosed late because early symptoms are subtle, misunderstood or ignored. Understanding early warning signs of heart related health issues is crucial, as timely action can prevent life-threatening events such as heart attacks and strokes.

Public health data consistently shows that most cardiovascular events are preceded by warning signals that appear weeks, months or even years earlier. Recognising these signs allows for early intervention and better long-term outcomes.

 

What Are Heart Related Health Issues?

Heart related health issues include conditions that affect:

  • the heart muscle
     

  • coronary arteries
     

  • heart valves
     

  • electrical system of the heart
     

Common conditions include coronary artery disease, heart failure, arrhythmias and hypertension-related heart damage.

 

Why Heart Problems Often Go Unnoticed

Heart disease is often called a “silent killer” because:

  • symptoms develop gradually
     

  • early signs are mild
     

  • discomfort is mistaken for fatigue or indigestion
     

  • people delay medical evaluation
     

Unfortunately, waiting for severe pain or emergencies increases risk.

 

Early Warning Signs of Heart Related Health Issues

Chest Discomfort

Chest pain or discomfort is the most recognised warning sign, but it does not always feel severe.

It may present as:

  • pressure
     

  • tightness
     

  • heaviness
     

  • burning sensation
     

Chest discomfort may come and go and worsen with exertion.

 

Breathlessness

Shortness of breath during routine activities or at rest may indicate:

  • reduced heart pumping capacity
     

  • fluid buildup in lungs
     

Breathlessness is often an early sign of heart failure or coronary disease.

 

Unusual Fatigue

Persistent, unexplained fatigue can signal reduced blood supply to the body.

People may notice:

  • exhaustion after minimal activity
     

  • reduced stamina
     

  • prolonged recovery after exertion
     

Fatigue is frequently overlooked as stress or ageing.

 

Palpitations or Irregular Heartbeat

Feeling the heart race, flutter or skip beats may indicate rhythm disturbances.

Symptoms include:

  • rapid heartbeat
     

  • pounding sensation
     

  • irregular pulse
     

Some arrhythmias increase stroke risk if untreated.

 

Dizziness or Lightheadedness

Reduced blood flow to the brain can cause:

  • dizziness
     

  • fainting spells
     

  • imbalance
     

These symptoms may signal heart rhythm or blood pressure issues.

 

Swelling in Legs or Ankles

Fluid retention in lower limbs suggests:

  • weakened heart function
     

  • poor circulation
     

Swelling often worsens by evening and improves overnight.

 

Pain in Other Areas

Heart-related pain may radiate to:

  • left arm
     

  • neck
     

  • jaw
     

  • back
     

  • upper abdomen
     

This atypical pain is common and frequently misdiagnosed.

 

Symptoms That Are More Common in Women

Women may experience:

  • nausea
     

  • jaw pain
     

  • back pain
     

  • extreme fatigue
     

  • shortness of breath without chest pain
     

These non-classic symptoms often delay diagnosis.

 

Risk Factors for Heart Related Health Issues

Major risk factors include:

  • high blood pressure
     

  • diabetes
     

  • high cholesterol
     

  • smoking
     

  • obesity
     

  • sedentary lifestyle
     

  • chronic stress
     

  • family history
     

Risk increases when multiple factors coexist.

 

Why Early Detection Is Critical

Early diagnosis:

  • prevents heart attacks
     

  • reduces heart muscle damage
     

  • lowers hospitalisation risk
     

  • improves quality of life
     

Most heart conditions are manageable when detected early.

 

How Heart Problems Are Diagnosed

Evaluation may involve:

  • blood pressure measurement
     

  • blood tests
     

  • electrocardiogram (ECG)
     

  • imaging studies
     

  • stress testing
     

Tests are chosen based on symptoms and risk profile.

 

Treatment and Management

Medical Management

Depending on the condition:

  • medications
     

  • lifestyle changes
     

  • monitoring
     

Early treatment slows disease progression.

 

Lifestyle Modification

Lifestyle plays a major role in heart health:

  • balanced diet
     

  • regular physical activity
     

  • stress management
     

  • adequate sleep
     

  • smoking cessation
     

Lifestyle changes significantly reduce risk.

 

Preventive Measures for Heart Health

  • regular health checkups
     

  • blood pressure and sugar monitoring
     

  • cholesterol screening
     

  • physical activity
     

  • heart-healthy diet
     

Prevention is the most effective strategy against heart disease.

 

When to Seek Immediate Medical Help

Seek urgent care if:

  • chest pain is severe or persistent
     

  • breathlessness occurs suddenly
     

  • fainting happens
     

  • pain radiates to arm or jaw
     

Prompt action saves lives.

 

Long-Term Impact of Ignoring Warning Signs

Ignoring early symptoms may lead to:

  • heart attack
     

  • stroke
     

  • heart failure
     

  • permanent heart damage
     

  • sudden cardiac events
     

Delayed care increases mortality risk.

 

Conclusion

Heart related health issues rarely appear suddenly without warning. The body often sends early signals such as chest discomfort, fatigue, breathlessness and palpitations long before emergencies occur. Recognising these early warning signs and seeking timely medical evaluation can prevent serious complications and save lives. Heart health requires awareness, proactive care and early action—because when it comes to the heart, ignoring symptoms is a risk no one should take.

 

References

  • Indian Council of Medical Research (ICMR) – Cardiovascular Disease Report

  •  World Health Organization (WHO) – Cardiovascular Health Guidelines

  • National Heart Institute – Early Signs of Heart Disease

  • Lancet – Global Burden of Cardiovascular Disease Studies

  • Indian Journal of Cardiology – Heart Disease Detection and Preventio

  •  Statista – Heart Disease Trends and Risk Factors

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