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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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National Dentist Day: Best Oral Hygiene Tips Shared by Experts

Every year, on March 6th, National Dentist Day is celebrated to recognize the invaluable contributions of dentists in maintaining our oral health. This special day also serves as a reminder of the importance of good oral hygiene habits. Whether you're looking to improve your daily dental routine or seeking expert advice, we’ve compiled the best oral hygiene tips shared by dentists to help you achieve a healthy and confident smile.

1. Brush Properly, Not Just Regularly

Brushing twice a day is essential, but how you brush matters just as much as how often. Experts recommend using a soft-bristled toothbrush and fluoride toothpaste. Follow these steps for effective brushing:

Use a gentle, circular motion rather than scrubbing.
Brush for at least two minutes twice a day.
Ensure you clean all tooth surfaces, including the back molars and gum line.

2. Flossing is Non-Negotiable

Flossing removes food particles and plaque from between your teeth where your toothbrush can’t reach. Dentists suggest flossing at least once a day to prevent cavities and gum disease. If traditional flossing is difficult, consider using:

Water flossers
Interdental brushes
Floss picks

3. Rinse with Mouthwash for Extra Protection

Using an antibacterial mouthwash helps reduce plaque, prevents bad breath, and protects against gum disease. Look for a fluoride-based or alcohol-free mouthwash, especially if you have sensitive gums.

Tip: Rinse for 30 seconds after brushing and flossing for best results.

4. Eat a Tooth-Friendly Diet

What you eat significantly impacts your oral health. Dentists recommend incorporating the following foods into your diet:

Dairy products (milk, cheese, yogurt) to strengthen enamel.
Crunchy fruits and vegetables (apples, carrots) to naturally clean teeth.
Nuts and seeds for essential minerals like calcium and phosphorus.
Green tea for its antibacterial properties.

Avoid excessive consumption of sugary snacks, acidic beverages, and sticky candies, which can erode enamel and lead to cavities.

5. Stay Hydrated and Limit Sugary Drinks

Drinking plenty of water helps wash away food particles and bacteria, keeping your mouth fresh and clean. Limit soda, sports drinks, and coffee, as they can stain teeth and contribute to decay.

Pro Tip: If you drink sugary or acidic beverages, use a straw to minimize direct contact with your teeth.

6. Replace Your Toothbrush Regularly

A worn-out toothbrush is ineffective at cleaning your teeth. Dentists recommend replacing your toothbrush every 3-4 months or sooner if the bristles are frayed. Using an electric toothbrush can also improve plaque removal.

7. Schedule Regular Dental Checkups

No matter how diligent your oral hygiene routine is, visiting your dentist every six months is crucial for professional cleanings and early detection of dental issues. Regular checkups can help prevent cavities, gum disease, and even serious health conditions linked to poor oral health.

8. Protect Your Teeth While Playing Sports

If you engage in contact sports, wearing a custom-fitted mouthguard can protect your teeth from injuries and fractures. This simple preventive measure can save you from costly dental treatments.

9. Avoid Smoking and Tobacco Products

Smoking and tobacco use are major contributors to gum disease, tooth loss, and oral cancer. If you’re looking for another reason to quit, your oral health is a great motivation. Talk to your dentist about resources to help you quit.

10. Teach Kids Good Oral Hygiene Habits Early

Children should learn proper oral hygiene habits from a young age. Encourage them to:

Brush their teeth with fluoride toothpaste.
Floss regularly.
Visit the dentist every six months.
Avoid excessive sweets and sugary drinks.

Setting a strong foundation for oral health can prevent future dental issues and ensure a lifetime of healthy smiles.

Conclusion

This National Dentist Day, take the opportunity to improve your oral care routine by following these expert tips. Good oral hygiene isn’t just about having a bright smile—it’s also essential for overall health and well-being. Show appreciation for your dentist by prioritizing your dental health and scheduling your next checkup.

For personalized dental care advice, consult a professional at SecondMedic, where expert guidance helps you maintain optimal oral health.