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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Flexible Work Schedules with Telehealth Support: A Smarter Approach to Employee Wellbeing

The modern workplace is undergoing a significant transformation. Rigid office hours and traditional healthcare access models are giving way to flexible work schedules and digital health solutions. One of the most impactful combinations emerging in corporate wellness is flexible work schedules with telehealth support.

This integrated approach addresses two critical challenges faced by today’s workforce: work-life imbalance and delayed healthcare access.

Why Workplace Health Models Need to Change

According to NITI Aayog and EY-FICCI workforce reports, Indian employees face rising levels of:

work-related stress
lifestyle diseases
burnout
absenteeism

Long working hours, commuting stress and limited time for medical visits worsen health outcomes. Flexible work arrangements and telehealth support directly address these gaps.

What Are Flexible Work Schedules?

Flexible work schedules allow employees to:

adjust start and end times
work remotely or in hybrid formats
manage personal commitments alongside work

Flexibility empowers employees to align work with their physical and mental health needs.

Understanding Telehealth Support

Telehealth uses digital platforms to deliver healthcare services such as:

online doctor consultations
follow-up care
preventive health advice
mental health support

It eliminates geographical and time barriers to healthcare.

Why Combining Flexibility with Telehealth Works

Individually, flexibility and telehealth are beneficial. Together, they create a powerful wellness ecosystem.

This combination allows employees to:

consult doctors without taking leave
manage chronic conditions proactively
address early symptoms promptly
reduce healthcare delays

Health Benefits for Employees

Reduced Stress and Burnout

Flexible schedules reduce time pressure, while telehealth removes healthcare-related anxiety.

Improved Access to Preventive Care

Employees are more likely to seek early consultations when care is convenient.

Better Management of Chronic Conditions

Conditions like hypertension, diabetes and thyroid disorders require regular follow-up, which telehealth supports efficiently.

Enhanced Mental Wellbeing

Tele-mental health services enable confidential and timely support.

Improved Work-Life Balance

Employees can prioritise health without compromising job responsibilities.

Productivity Benefits for Employers

Reduced Absenteeism

Quick access to care reduces prolonged sick leave.

Improved Employee Engagement

Health-supported employees show higher motivation and loyalty.

Lower Healthcare Costs

Preventive care reduces long-term medical claims.

Strong Employer Branding

Wellness-focused policies attract and retain talent.

Evidence Supporting Flexible Work and Telehealth

According to WHO and Lancet workplace health studies:

flexible work reduces stress-related disorders
telehealth improves healthcare utilisation
preventive care lowers chronic disease burden

Indian corporate data mirrors these findings, especially in hybrid work environments.

Role in Preventive Healthcare

Preventive healthcare focuses on early risk identification and lifestyle management.

Flexible schedules with telehealth support:

encourage routine checkups
support ongoing health monitoring
enable early intervention

This aligns with India’s preventive healthcare priorities outlined by NITI Aayog.

Addressing Common Concerns

Productivity Loss Myth

Multiple studies show flexible work improves output rather than reducing it.

Quality of Telehealth

Telehealth is effective for most primary care and follow-up needs.

Data Security

Modern telehealth platforms follow strict privacy and data protection standards.

Ideal Use Cases in the Workplace

This model is particularly effective for:

IT and corporate offices
remote and hybrid teams
organisations with distributed workforce
high-stress work environments

Implementation Best Practices

To maximise impact:

set clear flexibility guidelines
integrate telehealth access into HR benefits
promote preventive consultations
track wellness metrics

Leadership support is key to adoption.

Long-Term Organisational Impact

Organisations adopting this model report:

improved employee health indicators
reduced burnout
stronger workplace culture
sustainable productivity gains

Wellbeing becomes a strategic advantage.

Conclusion

Flexible work schedules with telehealth support represent the future of employee wellbeing. By removing barriers to healthcare access and allowing employees control over their work routines, this approach promotes preventive care, reduces stress and enhances productivity. As workplaces evolve, integrating flexibility with digital health support is not just an employee benefit—it is a strategic investment in long-term organisational health and resilience.

References

World Health Organization (WHO) – Workplace Health Promotion Framework
Indian Council of Medical Research (ICMR) – Lifestyle Disease and Workforce Health Studies
NITI Aayog – Digital Health and Workplace Wellness Reports
Lancet – Telehealth and Workforce Productivity Research
EY-FICCI – Corporate Wellness and Future of Work Reports
Statista – Telehealth Adoption and Workforce Trends

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