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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Virtual Cooking Class with Dietitian: A New Era of Healthy Eating in India

Healthy eating has become a top priority for individuals across India. With rising lifestyle diseases such as diabetes, hypertension, obesity and PCOS, food decisions now play a critical role in preventive healthcare. However, most people struggle with questions like what to cook, how to modify recipes, and how to balance nutrition with traditional Indian meals.

Virtual cooking classes with dietitians are transforming how Indians learn about food. They combine practical kitchen skills with scientific nutrition knowledge-something traditional cooking tutorials cannot offer. SecondMedic integrates expert dietitians, AI-driven nutrition analysis and preventive health frameworks to support individuals in building lifelong healthy eating habits.

This blog explores how virtual cooking classes work, why they matter and how they support long-term health.

Why India Needs Dietitian-Led Cooking Classes

Rising Lifestyle Diseases

The ICMR Nutrition and Metabolic Health Study reports alarming trends:

Over 100 million diabetic individuals
High prevalence of fatty liver
Vitamin deficiencies in large sections of the population
Increasing PCOS, thyroid disorders and obesity

Many of these conditions are strongly influenced by diet.

Lack of Nutrition Awareness

NFHS-5 highlights low dietary diversity among Indian households. People often overconsume oil, sugar and refined grains without realising the long-term impact.

Busy Lifestyles

Urban professionals struggle to plan meals due to:

Time constraints
Lack of structured nutrition knowledge
Dependence on takeaways and packaged food

Virtual cooking sessions solve these problems by offering guided, practical learning directly from home.

What Happens in a Virtual Cooking Class?

A SecondMedic virtual cooking class includes:

1. Live Demonstrations

Dietitians prepare recipes step-by-step while explaining:

Nutrient functions
Health benefits
Cooking techniques
Smart portion strategies

2. Ingredient Education

Participants learn about:

Low-GI alternatives
High-fibre grains
Clean protein sources
Anti-inflammatory spices
Healthy fats

3. Meal Planning Guidance

Classes often include weekly planning tips to simplify daily decisions.

4. Nutrient Breakdown

AI-based tools analyse the recipe’s:

Sugar load
Sodium balance
Protein density
Vitamin & mineral profile

5. Condition-Specific Variations

Recipes can be adapted for:

Diabetes
PCOS
Thyroid health
Heart health
Weight loss

This ensures suitability across lifestyles.

Benefits of Virtual Cooking Classes

1. Practical, Hands-On Learning

Participants cook alongside the dietitian, making learning interactive and easy to remember.

2. Prevention-Focused

Unlike regular cooking tutorials, these sessions emphasise preventive eating patterns recommended by WHO and NITI Aayog.

3. Customisable for Families

Healthy recipes become household-friendly, improving community nutrition.

4. Convenient and Accessible

Join from anywhere without travel or scheduling challenges.

5. Increases Long-Term Adherence

When people understand why a recipe is healthy, they adopt it more consistently.

Example Recipe Taught in Class

Vegetable Khichdi (Diabetes-Friendly Version):

Moong dal for high protein
Mixed vegetables for fibre
Minimal ghee
Brown rice/millet for lower GI
Turmeric + cumin for anti-inflammatory benefit

SecondMedic’s AI engine evaluates glycaemic impact and micronutrient density.

Integrating Virtual Cooking With Preventive Care

SecondMedic combines cooking classes with:

Teleconsultations
Diet assessments
AI nutrition scores
Weight and glucose monitoring
Lifestyle coaching

This creates a unified ecosystem for long-term behaviour change.

Conclusion

Virtual cooking classes with dietitians empower individuals to transform their daily meals into preventive healthcare tools. By teaching practical skills, nutrition fundamentals and personalised recipe adjustments, these classes make healthy eating accessible, enjoyable and sustainable.

SecondMedic is redefining preventive nutrition by blending expert guidance with digital interactivity and AI insights-helping people cook better, eat smarter and live healthier.

References

• ICMR Nutrition & Metabolic Health Study - Dietary Impact on Chronic Diseases
• National Family Health Survey (NFHS-5), Ministry of Health & Family Welfare
• NITI Aayog - Preventive Healthcare & Nutrition Strategy for India
• WHO Healthy Eating & Non-Communicable Disease Guidelines
• Lancet Public Health - Effectiveness of Lifestyle Interventions
• Statista India Digital Health & Online Learning Trends
• EY-FICCI Digital Nutrition & Virtual Wellness Report

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