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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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5K Run for a Cause: How Community Fitness Drives Preventive Health Awareness

Physical activity is one of the most effective tools for disease prevention, yet it remains underutilised in everyday life. Community-based fitness initiatives such as a 5K Run for a Cause play a powerful role in bridging this gap by making movement accessible, meaningful and socially engaging. These events combine the benefits of exercise with awareness-building, creating lasting impact on public health.

In India, lifestyle-related diseases such as diabetes, heart disease and obesity are rising rapidly. According to the Indian Council of Medical Research (ICMR) and National Family Health Survey (NFHS-5), physical inactivity is a major contributor to this growing burden. Events that encourage structured, enjoyable physical activity help counter this trend.

What Is a 5K Run for a Cause?

A 5K Run for a Cause is a short-distance running or walking event designed to promote fitness while supporting a health, social or community objective. Participants may run, jog or walk the 5-kilometre distance, making the event inclusive for people of varying fitness levels.

Beyond physical activity, these runs aim to:

raise awareness about preventive health
encourage active lifestyles
build community participation
support wellness-driven causes

Why 5K Is an Ideal Distance

The 5-kilometre distance is widely recognised as:

achievable for beginners
challenging enough to promote fitness
safe for most age groups with minimal training

WHO physical activity guidelines support moderate-intensity exercise like running or brisk walking for improving cardiovascular and metabolic health.

Health Benefits of Participating in a 5K Run

Improved Cardiovascular Health

Running and brisk walking strengthen the heart, improve circulation and lower blood pressure. Regular participation reduces the risk of heart disease and stroke.

Better Metabolic Health

Physical activity improves insulin sensitivity and supports weight management. ICMR data shows that regular movement significantly reduces diabetes risk.

Enhanced Mental Wellbeing

Exercise releases endorphins that reduce stress, anxiety and depression. Community runs add a social element that further supports mental health.

Improved Musculoskeletal Strength

Running strengthens muscles, bones and joints, reducing the risk of age-related mobility issues.

Role of 5K Runs in Preventive Healthcare

Preventive healthcare focuses on reducing disease risk before illness develops. A 5K Run for a Cause supports prevention by:

promoting physical activity
encouraging regular movement habits
raising awareness about lifestyle diseases
motivating health-conscious behaviour

NITI Aayog identifies physical activity promotion as a key pillar of preventive healthcare in India.

Community Impact of a 5K Run for a Cause

Building Health Awareness

Runs often highlight specific causes such as heart health, diabetes prevention or mental wellbeing, reinforcing public health messages.

Strengthening Social Bonds

Community participation fosters shared goals and mutual motivation, increasing long-term adherence to healthy habits.

Encouraging Family Participation

Inclusive events encourage families to adopt healthier lifestyles together.

5K Runs and Corporate Wellness Programs

Corporate wellness programs increasingly include physical activity initiatives.

Benefits for organisations include:

improved employee engagement
reduced absenteeism
enhanced team bonding
positive employer branding

EY-FICCI reports show that wellness initiatives focused on physical activity deliver strong participation and measurable health benefits.

Accessibility and Inclusivity

A key strength of 5K runs is inclusivity.

They accommodate:

first-time runners
walkers
older adults
people transitioning to active lifestyles

This inclusiveness reduces barriers to participation.

Supporting Long-Term Behaviour Change

One-time events create awareness, but their true value lies in inspiring long-term change.

Participants often:

continue walking or running regularly
become more conscious of fitness
seek preventive health checkups

Lancet studies indicate that community-based physical activity initiatives can influence long-term health behaviours.

Safety and Health Considerations

For safe participation:

individuals should assess fitness levels
warm-up and cool-down are essential
hydration should be prioritised
those with medical conditions should seek medical advice

Proper guidance ensures benefits without injury.

Role of Awareness and Education

Successful runs integrate education through:

health talks
informational materials
screening camps
wellness resources

This combination reinforces preventive health messages.

Measuring Impact

Impact can be assessed through:

participation rates
follow-up health initiatives
employee engagement metrics
community feedback

Data-driven evaluation improves future program design.

Why 5K Runs Matter in India

India faces challenges such as:

rising sedentary lifestyles
limited health awareness
increasing chronic disease burden

Community fitness events provide a scalable, low-cost solution to promote active living and prevention.

Conclusion

A 5K Run for a Cause is more than a fitness event—it is a preventive health movement. By combining physical activity with purpose, these runs encourage healthier lifestyles, strengthen community bonds and raise awareness about long-term wellbeing. In a country where lifestyle diseases are growing rapidly, initiatives that make movement accessible and meaningful are essential. A simple 5K run can be a powerful step toward a healthier, more active society.

References

ICMR – Physical Activity and Lifestyle Disease Prevention Reports
National Family Health Survey (NFHS-5) – Physical Activity and Health Data
NITI Aayog – Preventive Healthcare and Physical Activity Promotion Strategy
WHO – Physical Activity and Health Guideline
Lancet – Community Fitness and Preventive Health Studies
Statista – Fitness Events and Participation Trends India
EY-FICCI – Corporate Wellness and Physical Activity Reports

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