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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Employee Wall of Fame: Celebrating Uniqueness to Build a Positive Workplace Culture

In today’s evolving workplaces, employee engagement is no longer driven solely by compensation or job titles. People seek recognition, inclusion and a sense of belonging. One of the most effective yet simple ways to achieve this is through an Employee Wall of Fame. By celebrating individuality and contribution, organisations can create a culture where employees feel seen, valued and motivated.

Recognition is not a luxury. It is a fundamental driver of organisational wellbeing and performance.

Why Recognition Matters in the Workplace

Recognition fulfills a basic human need: appreciation.

When employees feel recognised:

morale improves
motivation increases
loyalty strengthens
burnout reduces

According to global workplace studies, lack of recognition is one of the top reasons for employee disengagement.

What Is an Employee Wall of Fame?

An Employee Wall of Fame is a physical or digital space dedicated to highlighting employees for their achievements, values, creativity or unique strengths.

It may showcase:

professional accomplishments
teamwork contributions
innovation and problem-solving
leadership qualities
personal milestones

The focus is not competition, but appreciation.

Celebrating Uniqueness, Not Just Performance

Traditional recognition often focuses only on targets or numbers.

A Wall of Fame expands recognition to include:

collaboration
consistency
empathy
creativity
positive attitude

This approach ensures diverse strengths are valued.

Psychological Impact of Workplace Recognition

Recognition positively affects mental health.

Benefits include:

improved self-esteem
reduced stress
increased sense of purpose
stronger emotional connection to work

WHO recognises psychosocial wellbeing as a key component of healthy workplaces.

Inclusion and Belonging Through Recognition

Celebrating uniqueness supports inclusion.

It helps:

recognise diverse backgrounds
reduce bias
promote equal visibility

When employees see people like themselves being appreciated, trust and belonging grow.

Employee Wall of Fame as a Culture-Building Tool

Culture is shaped by what organisations choose to celebrate.

A visible Wall of Fame:

reinforces company values
sets behavioural standards
inspires others

It becomes a living reflection of organisational culture.

Types of Recognition on a Wall of Fame

Achievement-Based Recognition

For milestones, project success or innovation.

Value-Based Recognition

For demonstrating company values such as integrity or teamwork.

Peer Recognition

Employees nominate colleagues, increasing engagement.

Personal Growth Recognition

Celebrating learning, upskilling or personal achievements.

How an Employee Wall of Fame Improves Engagement

Engaged employees:

perform better
collaborate more
stay longer

EY-FICCI workplace studies show recognition-driven programs significantly improve engagement scores.

Impact on Productivity and Performance

Recognition creates positive reinforcement.

Employees who feel valued:

take ownership of work
show initiative
maintain consistency

Appreciation fuels sustained performance.

Supporting Mental Wellbeing at Work

Recognition reduces workplace stress by:

validating effort
reducing feelings of invisibility
encouraging positive feedback loops

Mental wellbeing improves when employees feel respected and acknowledged.

How to Design an Effective Employee Wall of Fame

Key principles include:

inclusivity
transparency
fairness
consistency

Clear criteria prevent bias and ensure credibility.

Physical vs Digital Wall of Fame

Physical Wall

Creates visual impact in office spaces.

Digital Wall

Ideal for remote or hybrid teams.

Both formats can coexist for maximum reach.

Frequency of Updates Matters

Stale recognition loses impact.

Best practices include:

monthly highlights
quarterly rotations
special occasion features

Fresh content sustains enthusiasm.

Role of Leadership in Recognition

Leadership participation strengthens impact.

When leaders:

nominate employees
share appreciation publicly

recognition becomes part of organisational identity.

Employee Participation and Ownership

Encouraging peer nominations:

increases engagement
reduces hierarchy
builds mutual respect

Recognition becomes a shared responsibility.

Measuring the Impact of Recognition Initiatives

Impact can be assessed through:

engagement surveys
retention metrics
feedback forms
participation rates

Data-driven insights help refine programs.

Long-Term Benefits of Celebrating Uniqueness

Over time, organisations experience:

stronger culture
higher retention
improved employer branding
healthier workplace relationships

Recognition is a long-term investment, not a one-time activity.

Common Mistakes to Avoid

Avoid:

recognising only top performers
favouritism
lack of transparency
irregular updates

Consistency and fairness are essential.

Employee Wall of Fame as Part of Holistic Wellness

Recognition complements:

mental health initiatives
team-building programs
wellness activities

A supportive culture enhances overall wellbeing.

Conclusion

An Employee Wall of Fame is more than a display—it is a statement of values. By celebrating uniqueness and recognising diverse contributions, organisations create workplaces where people feel valued, motivated and connected. In an era where employee wellbeing and engagement define success, recognition-driven initiatives like a Wall of Fame play a vital role in building resilient, inclusive and high-performing teams. Celebrating people is not just good culture—it is good leadership.

References

World Health Organization (WHO) – Workplace Mental Health and Wellbeing
EY-FICCI – Employee Engagement and Workplace Culture Reports
NITI Aayog – Future of Work and Organisational Wellbeing Studies
Lancet – Psychosocial Work Environment Research
Statista – Global Employee Engagement and Recognition Trends

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