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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Anemia Diet Plan: What to Eat to Improve Hemoglobin Levels Naturally

Anemia is one of the most widespread nutritional disorders in India, affecting people across age groups. According to NFHS-5 and ICMR data, more than half of Indian women and a significant proportion of men suffer from anemia. While supplements are sometimes required, a structured anemia diet plan plays a central role in preventing and managing the condition.

Anemia occurs when the body lacks sufficient healthy red blood cells or hemoglobin to carry oxygen efficiently. Nutrition is the foundation of hemoglobin production, making dietary correction essential.

Understanding the Nutritional Causes of Anemia

Anemia commonly results from deficiencies of:

iron
vitamin B12
folate

Each nutrient plays a specific role in red blood cell formation.

Iron: The Core Nutrient in Anemia

Iron is a key component of hemoglobin.

Iron deficiency leads to:

fatigue
weakness
pale skin
shortness of breath

ICMR identifies iron deficiency as the leading cause of anemia in India.

Types of Dietary Iron

Heme Iron

Found in animal foods and absorbed efficiently.

Sources include:

eggs
fish
chicken
liver

Non-Heme Iron

Found in plant-based foods and absorbed less efficiently.

Sources include:

spinach
lentils
chickpeas
jaggery
dates

Vitamin C improves non-heme iron absorption.

Role of Vitamin B12 in Anemia

Vitamin B12 is essential for red blood cell maturation.

Deficiency causes:

megaloblastic anemia
nerve symptoms
memory issues

Vegetarians are at higher risk due to limited dietary sources.

Role of Folate

Folate supports:

DNA synthesis
red blood cell formation

Low folate intake worsens anemia, especially during pregnancy.

Foods to Include in an Anemia Diet Plan

Iron-Rich Foods

green leafy vegetables (spinach, amaranth)
legumes and pulses
dates, raisins and figs
jaggery
red meat and eggs

Vitamin C-Rich Foods

citrus fruits
guava
tomatoes
bell peppers

These enhance iron absorption.

Vitamin B12 Sources

milk and dairy products
eggs
fish
fortified cereals

Folate-Rich Foods

green leafy vegetables
beans and peas
peanuts
whole grains

Sample Daily Anemia Diet Plan

Breakfast

vegetable omelette or sprouted moong
citrus fruit or guava

Mid-Morning

soaked raisins or dates
lemon water

Lunch

brown rice or roti
dal or chickpeas
green leafy vegetable sabzi
salad with lemon dressing

Evening Snack

roasted peanuts or chana
fruit rich in vitamin C

Dinner

vegetable curry with paneer or fish
whole wheat roti
lightly cooked greens

Bedtime

warm milk if tolerated

Foods That Reduce Iron Absorption

Certain foods interfere with iron absorption:

tea and coffee
excess calcium
highly processed foods

These should be avoided close to iron-rich meals.

Special Considerations for Women

Women require more iron due to:

menstruation
pregnancy
lactation

NFHS-5 highlights anemia as a major women’s health concern in India.

Anemia in Men and Older Adults

In men and elderly individuals, anemia may signal:

nutritional deficiency
chronic disease
gastrointestinal issues

Dietary correction should be combined with medical evaluation.

When Diet Alone Is Not Enough

Diet may not be sufficient if:

anemia is severe
absorption is impaired
chronic illness is present

In such cases, supplements or treatment of underlying causes is required.

Importance of Regular Blood Tests

Monitoring hemoglobin helps:

assess improvement
guide dietary adjustments
prevent recurrence

Preventive checkups are essential for high-risk groups.

Lifestyle Factors That Support Recovery

Along with diet:

adequate sleep
stress management
regular physical activity

support blood health and recovery.

Preventing Anemia Long-Term

Long-term prevention includes:

balanced meals
iron-rich cooking methods
avoiding excessive junk food
periodic screening

WHO and NITI Aayog emphasize nutrition education as a preventive strategy.

Conclusion

A well-structured anemia diet plan is the cornerstone of improving hemoglobin levels and restoring energy. By including iron-rich foods, supporting nutrients like vitamin B12 and folate, and improving absorption through smart food combinations, anemia can be effectively managed and prevented. Early dietary intervention, supported by regular health monitoring, helps avoid long-term complications and improves overall quality of life.

References

Indian Council of Medical Research (ICMR) – Anemia and Micronutrient Deficiency Reports
National Family Health Survey (NFHS-5) – Anemia Prevalence Data
World Health Organization (WHO) – Nutrition and Anemia Guidelines
Lancet – Micronutrient Deficiency and Public Health Research
NITI Aayog – Poshan Abhiyaan and Nutrition Policy Reports
Statista – Nutrition and Health Trends in India

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