• Published on: Jul 17, 2020
  • 2 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

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An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers. 

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Do Late-Night Meals Cause Weight Gain

Do Late-Night Meals Cause Weight Gain? Let’s Uncover the Truth

Many of us have a habit of snacking late at night or even having a full meal right before bed. Whether it’s a busy schedule, late-night cravings, or watching movies with snacks, eating late has become quite common. But the big question is—do late-night meals cause weight gain?

Let’s explore what science says, how your body responds to late meals, and tips to manage your eating habits for better health and weight control.

 

Why We Eat Late at Night

In today’s fast-paced life, late-night eating often happens because of:

  • Long working hours or night shifts
     

  • Skipping meals during the day
     

  • Emotional eating or stress
     

  • Social gatherings or weekend habits
     

While occasional late-night eating may not harm you, making it a routine could have consequences—especially if the food choices aren’t healthy.

 

How Your Body Works While You Sleep

Your body doesn’t shut down at night—it continues working. However, the metabolism slows down because your body prepares for rest, not digestion. Late-night meals, especially heavy or sugary ones, are digested more slowly.

During sleep, your energy demand is low, so the extra calories consumed at night are more likely to be stored as fat rather than burned for energy.

 

Late-Night Eating and Weight Gain: What's the Link?

Several studies show that when you eat is just as important as what you eat. Here’s why eating late may contribute to weight gain:

Calorie Surplus

Late-night meals usually come after you've already eaten enough during the day. So, you’re adding more calories than your body needs—leading to weight gain.

Poor Food Choices

People tend to eat unhealthy foods at night—like chips, ice cream, sugary drinks, or fast food. These high-calorie items with little nutrition easily lead to fat storage.

Hormonal Imbalance

Late eating can affect hormones like insulin, leptin, and ghrelin, which regulate hunger and fat storage. Disrupted hormonal patterns can make you feel hungrier the next day and crave more junk food.

Disrupted Sleep

Heavy meals before bed can cause bloating, acidity, or indigestion—leading to poor sleep. Poor sleep affects metabolism, increases hunger hormones, and makes weight gain more likely.

 

Common Myths About Late-Night Eating

Let’s bust a few myths:

Myth: Eating after 8 PM always causes weight gain.
Fact: It depends on how much and what you eat. A light snack at 9 PM is very different from a greasy burger at midnight.

Myth: Your body stores everything as fat at night.
Fact: If your total daily calories are under control and your food choices are healthy, you won’t automatically gain weight.

 

When Late-Night Meals Might Be Okay

Late-night eating isn’t always harmful—especially if:

  • You’ve had a long gap between meals
     

  • You're genuinely hungry (not just bored)
     

  • You choose a light and balanced snack like:
     

    • A handful of almonds
       

    • Greek yogurt
       

    • A banana or boiled egg
       

    • Warm turmeric milk
       

These foods are low in calories and promote better sleep.

 

Best Time to Eat Dinner

Nutrition experts recommend having your last major meal 2 to 3 hours before bedtime. For example, if you sleep at 10:30 PM, aim to finish dinner by 7:30–8:00 PM.

This gives your body enough time to digest food before you lie down, preventing bloating, heartburn, and excess fat storage.

 

Tips to Avoid Late-Night Overeating

Here’s how to manage your night-time hunger:

1. Eat Balanced Meals During the Day

Don’t skip breakfast or lunch. When you eat regularly, you’re less likely to feel hungry late at night.

2. Hydrate Properly

Thirst is often mistaken for hunger. Drink water before reaching for a snack.

3. Plan Your Dinner Time

Set a regular time for dinner. Make it a light, protein-rich meal with veggies.

4. Don’t Eat Out of Boredom

Keep yourself busy. Sometimes a walk, a warm shower, or reading helps more than food.

5. Sleep on Time

Late sleepers are more likely to snack. A fixed sleep schedule helps control hunger hormones.

 

Healthy Late-Night Snack Ideas

If you truly need something to eat before bed, try:

  • Low-fat yogurt
     

  • Whole-grain crackers with peanut butter
     

  • A small fruit like apple or kiwi
     

  • Herbal teas like chamomile or tulsi
     

Avoid spicy, fried, or sugary foods—they’ll disrupt sleep and digestion.

 

What You Can Do for Weight Control

If you're struggling with weight or digestion, consider a weight management test panel. Thyrocare (via SecondMedic) offers:

  • Thyroid test – to rule out hormonal causes
     

  • Vitamin & lipid profile – for metabolic insight
     

  • Fasting glucose & HbA1c – for sugar levels
     

These tests help identify if late-night eating is affecting your metabolism or sugar levels.

 

Conclusion

So, do late-night meals cause weight gain? The answer depends on what, how much, and how often you eat late at night. Eating a heavy or high-calorie meal before bed regularly can absolutely lead to weight gain over time.

The key is to eat mindfully, stick to healthy choices, and maintain a consistent eating and sleeping schedule. Occasional late-night snacks won’t hurt—but turning them into a habit will.

To protect your health and manage weight, be aware of what you eat, and when you eat—because yes, do late-night meals cause weight gain? Absolutely, if you're not careful.

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