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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Virtual Second Opinion Services India: Making Medical Decisions Safer, Smarter, and More Accurate

Healthcare decisions can be overwhelming, especially when dealing with serious diagnoses, complex treatment options, or long-term health conditions. In India, where diagnostic variability and specialist availability differ across regions, seeking a second medical opinion has become essential for clarity and confidence. Virtual second opinion services India allow patients to consult top specialists online, review diagnoses, validate reports, and confirm treatment plans without traveling long distances.

SecondMedic has emerged as a trusted platform for virtual second opinions, connecting users with experienced specialists across cardiology, oncology, neurology, orthopedics, nephrology, endocrinology, and other medical fields. These services empower patients with accurate information and reduce the risk of misdiagnosis or unnecessary treatments.

Why Second Opinions Are Becoming Important in India

According to WHO, nearly 20-30% of medical errors globally stem from misdiagnoses. In India, disparities in medical access and diagnostic quality can make it harder for patients to rely on a single opinion-especially for complex or high-risk conditions.

Patients seek second opinions for:

Cancer diagnosis
Cardiac issues (blockages, angioplasty recommendations)
Orthopedic surgeries
Neurological disorders
Kidney and liver conditions
Autoimmune diseases
Rare or chronic illnesses

A second opinion ensures that treatment decisions are well-informed and evidence-based.

How Virtual Second Opinion Services Work

Virtual second opinion platforms like SecondMedic make the process simple and accessible.

Steps include:

Uploading medical reports, scans, prescriptions, and lab results.
Selecting the specialty or condition.
AI tools help summarize and organize the case.
A specialist reviews the case in detail.
The patient receives a written report or video consultation explaining the recommendations.
Follow-up guidance is provided when needed.

This digital-first approach saves time and helps patients receive expert evaluations from anywhere in India.

Key Benefits of Virtual Second Opinions

1. Access to Top Specialists

Patients can connect with some of India's best doctors without needing to visit major metro hospitals.

2. Prevention of Misdiagnosis

A fresh review reduces the risk of incorrect or incomplete diagnoses.

3. Verification of Treatment Plans

Before committing to surgery or long-term therapy, patients receive reassurance and clarity.

4. Time and Cost Savings

Virtual reviews eliminate travel, long waiting lines, and high hospital consultation fees.

5. Emotional Confidence

Patients and families gain peace of mind through expert validation of medical decisions.

SecondMedic ensures case reviews are thorough, unbiased, and personalized.

Use Cases Where Second Opinions Make a Big Difference

Oncology

Cancer diagnoses often require multi-specialty inputs. Virtual tumor board reviews help patients choose the right treatment path.

Cardiology

Heart conditions like blockages, angioplasty recommendations, or arrhythmia management require accurate evaluations.

Orthopedics

Joint replacement or spine surgery recommendations often need second validation to avoid unnecessary procedures.

Neurology

Conditions like epilepsy, stroke, or movement disorders benefit from deeper case review.

Chronic Illnesses

Diabetes, hypertension, kidney disease, and thyroid disorders require long-term management strategies.

Why Virtual Second Opinion Is Better Than In-Person for Many Patients

More specialist availability
Faster review times
Ability to compare multiple expert opinions
Digital access to consolidated medical records
Better accommodation of busy schedules
Suitable for rural patients with limited access to tertiary care hospitals

Digital second opinions remove geographic barriers completely.

The Role of Technology in Second Opinions

AI enhances the clarity and accuracy of second opinions by:

Pre-sorting medical documents
Highlighting abnormalities in lab results
Summarizing doctor notes
Identifying missing tests
Flagging potential medical risks

SecondMedic combines AI insights with top specialist expertise, resulting in stronger, data-backed recommendations.

Challenges in India’s Traditional Second Opinion System

Long wait times at major hospitals
Difficulty obtaining complete medical records
Travel to metro cities
Lack of specialized doctors in Tier 2/3 cities
Inconsistent diagnostic quality

Virtual second opinion services solve all of these pain points.

Future Outlook

Virtual medical reviews will continue growing with:

AI-powered case analysis
Integration with electronic health records (EHRs)
Multi-specialty collaborative boards
Predictive diagnostics
Global doctor networks

SecondMedic aims to lead this space by offering deeper, faster, and more accurate medical reassessments.

Conclusion

Virtual second opinion services India empower patients to make informed, safe, and confident healthcare decisions. By connecting users with top specialists and leveraging AI-driven insights, SecondMedic ensures that every major medical choice is backed by expertise and clarity. This is especially valuable for complex diagnoses, chronic conditions, and surgical recommendations.

To request a virtual second opinion, visit www.secondmedic.com

References

WHO - Misdiagnosis data and clinical errors
NITI Aayog - Digital health transformation reports
ABDM - Digital health records and interoperability
Statista - Telehealth adoption in India
Lancet & NEJM - Studies on second opinions
SecondMedic clinical team insights

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