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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Neurobion Forte: Benefits for Nerve Health and Vitamin B Deficiency

Vitamin deficiencies are a common but often overlooked health issue. Among them, vitamin B deficiency is particularly significant because of its direct impact on nerve function, energy metabolism and overall neurological health. Neurobion Forte is a widely used vitamin B-complex supplement designed to address these deficiencies and support nerve health.

Understanding how Neurobion Forte works and when it is beneficial helps individuals make informed decisions about their nutritional and neurological wellbeing.

What Is Neurobion Forte?

Neurobion Forte is a combination supplement containing essential B vitamins, primarily:

vitamin B1 (thiamine)
vitamin B6 (pyridoxine)
vitamin B12 (cobalamin)

These vitamins play a vital role in nerve signal transmission, energy production and maintenance of the nervous system.

Why Vitamin B Is Essential for Nerve Health

B vitamins are crucial for:

nerve impulse transmission
myelin sheath formation
energy metabolism in nerve cells

Deficiency can impair nerve function, leading to discomfort and neurological symptoms.

Common Causes of Vitamin B Deficiency

Vitamin B deficiency may occur due to:

inadequate dietary intake
poor absorption
chronic illnesses
long-term medication use
alcohol misuse

Vegetarians and elderly individuals are particularly at risk of vitamin B12 deficiency.

Symptoms of Vitamin B Deficiency

Early symptoms may include:

fatigue
weakness
numbness or tingling in hands and feet
poor concentration

If untreated, deficiency may progress to more serious neurological problems.

How Neurobion Forte Supports Nerve Health

Supports Nerve Repair

Vitamin B12 contributes to nerve regeneration and maintenance of nerve fibres.

Improves Nerve Signal Transmission

Vitamin B1 supports proper nerve impulse conduction.

Reduces Nerve Irritation

Vitamin B6 helps regulate neurotransmitter synthesis, reducing nerve-related discomfort.

Supports Energy Metabolism

B vitamins help convert food into energy, supporting overall nerve and muscle function.

Role of Neurobion Forte in Nerve Pain

Nerve pain caused by vitamin deficiency may present as:

burning sensation
tingling
numbness
shooting pain

In such cases, correcting the deficiency through supplementation may help relieve symptoms over time.

Conditions Where Neurobion Forte Is Commonly Used

Neurobion Forte may be prescribed or recommended in cases such as:

peripheral neuropathy
diabetic neuropathy (as supportive care)
nutritional deficiency-related nerve symptoms
general weakness associated with vitamin B deficiency

It is not a painkiller but supports underlying nutritional correction.

Importance of Medical Guidance

While vitamin supplements are widely available, inappropriate or excessive use may cause side effects.

Medical guidance ensures:

correct diagnosis
appropriate dosage
monitoring of response

Self-medication should be avoided, especially for long-term use.

Diet and Vitamin B Intake

Dietary sources of B vitamins include:

whole grains
legumes
dairy products
eggs
meat and fish

Balanced nutrition remains the foundation of vitamin sufficiency.

Who May Benefit Most from Neurobion Forte?

Individuals who may benefit include:

those with confirmed vitamin B deficiency
people with nerve-related symptoms
elderly individuals with poor nutrient absorption
individuals with restricted diets

Supplementation should complement dietary improvement.

Possible Side Effects and Precautions

When taken as advised, Neurobion Forte is generally well tolerated.

However:

excessive vitamin B6 intake may cause nerve symptoms
allergic reactions are rare but possible

Always follow professional advice.

How Long Does It Take to See Benefits?

Improvement depends on:

severity of deficiency
duration of symptoms
individual health status

Some people notice symptom improvement within weeks, while others require longer support.

Neurobion Forte and Overall Wellbeing

Correcting vitamin B deficiency supports:

nerve health
energy levels
cognitive function
overall vitality

Supplementation is most effective when combined with healthy lifestyle habits.

Conclusion

Neurobion Forte plays an important role in managing vitamin B deficiency and supporting nerve health. By supplying essential B vitamins, it helps restore nerve function, reduce deficiency-related symptoms and improve overall neurological wellbeing. While it can be highly beneficial when deficiency is present, its use should always be guided by medical advice to ensure safety and effectiveness. Balanced nutrition, early diagnosis and appropriate supplementation together form the foundation of healthy nerve function.

References

World Health Organization (WHO) – Micronutrients and Neurological Health
Indian Council of Medical Research (ICMR) – Nutrient Deficiency Guidelines
National Institute of Nutrition (NIN) – Vitamin B and Nerve Function Reports
Lancet Neurology – Vitamin Deficiency and Neuropathy Studies
Indian Journal of Clinical Nutrition – Vitamin B Supplementation Researc
Statista – Dietary Supplement Usage Trends

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