• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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How Your Sleep Schedule Affects Digestion

How Your Sleep Schedule Affects Digestion

In today’s fast-paced world, staying up late has become a norm—whether for work, binge-watching, or scrolling on phones. But did you know your late-night habits can negatively impact your digestion?

Yes! Your sleep schedule and digestive health are deeply connected. Let’s explore how poor sleep affects your gut, the symptoms to watch for, and simple ways to improve both.

 

Sleep and Gut – What’s the Link?

Your body follows a 24-hour internal clock, called the circadian rhythm. This biological clock not only controls your sleep-wake cycle but also governs other body functions—including digestion.

When you sleep on time, your digestive system gets enough rest and follows its natural detox and repair routine. But irregular or insufficient sleep disrupts hormonal flow, slows down digestion, and affects gut bacteria.

 

Signs Your Sleep Is Hurting Your Digestion

Let’s look at how poor sleep shows up in your gut health:

 

1. Bloating & Gas in the Morning

Waking up with a heavy, bloated stomach could mean your food didn’t digest properly overnight due to late meals and sleep disruption.

 

2. Constipation or Irregular Bowel Movements

Your colon is most active in the early morning. Late nights confuse this rhythm, making bowel movements irregular or difficult.

 

3. Frequent Acidity or Heartburn

Poor sleep posture or sleeping soon after eating can lead to acid reflux and heartburn at night or in the morning.

 

4. Low Appetite or Indigestion

Sleep deprivation weakens stomach acid production and gut motility, leading to poor breakdown of food.

 

5. Brain Fog and Fatigue

Your gut produces over 90% of serotonin—a chemical that affects mood and alertness. Poor sleep affects gut function, which in turn impacts mental clarity.

 

Your Gut Microbiome Has a Sleep Cycle Too

Inside your intestines live trillions of bacteria—your gut microbiome. These bacteria help digest food, absorb nutrients, and maintain immunity.

Recent studies show that gut bacteria also follow a circadian rhythm. When your sleep is disturbed, these good bacteria get confused too—leading to:

  • Poor digestion
     

  • Inflammation
     

  • Weakened immunity
     

  • Increased sugar cravings
     

 

What’s the Ideal Sleep Schedule for Good Digestion?

Aim for:

  • Sleeping between 10 PM and 6 AM
     

  • 7–8 hours of quality, uninterrupted rest
     

  • Avoiding meals 2–3 hours before bedtime
     

This helps your digestive organs function properly during sleep and your body to detox naturally.

 

6 Simple Tips to Improve Sleep and Digestion Together

 

1. Follow a Fixed Sleep Schedule

Go to bed and wake up at the same time daily—even on weekends.

 

2. Avoid Heavy Late-Night Meals

Have dinner 2–3 hours before bed. Choose light, easy-to-digest foods.

 

3. Limit Caffeine and Sugar in Evenings

They disturb sleep patterns and irritate your digestive lining.

 

4. Add a Night Walk

A 10–15 minute slow walk after dinner improves digestion and helps your body wind down.

 

5. Practice Screen-Free Time Before Bed

Blue light from screens affects melatonin production—try reading, journaling, or deep breathing instead.

 

6. Stay Hydrated During the Day

But avoid too much water just before bed to prevent waking up to pee.

 

When to See a Doctor

If you face chronic indigestion, acidity, constipation, or fatigue, even with a good lifestyle, consult a healthcare provider. You may need tests for:

  • Gut health
     

  • Liver enzymes
     

  • Hormone levels
     

  • Vitamin deficiencies
     

  • Sleep disorders like sleep apnea
     

You can easily book these via SecondMedic.com, which offers Thyrocare lab services and home sample collection.

 

Conclusion

Your gut and brain are best friends. And your sleep schedule plays a major role in keeping this bond healthy.

If you’ve been feeling bloated, tired, or irregular lately—it may not be your food, but your sleep. Now that you know how your sleep schedule affects digestion, try making small changes to improve both. Better sleep = better gut = better life.

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