MRNA Vaccines – Uses Beyond COVID

mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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National Dentist Day: Best Oral Hygiene Tips Shared by Experts

Every year, on March 6th, National Dentist Day is celebrated to recognize the invaluable contributions of dentists in maintaining our oral health. This special day also serves as a reminder of the importance of good oral hygiene habits. Whether you're looking to improve your daily dental routine or seeking expert advice, we’ve compiled the best oral hygiene tips shared by dentists to help you achieve a healthy and confident smile.

1. Brush Properly, Not Just Regularly

Brushing twice a day is essential, but how you brush matters just as much as how often. Experts recommend using a soft-bristled toothbrush and fluoride toothpaste. Follow these steps for effective brushing:

Use a gentle, circular motion rather than scrubbing.
Brush for at least two minutes twice a day.
Ensure you clean all tooth surfaces, including the back molars and gum line.

2. Flossing is Non-Negotiable

Flossing removes food particles and plaque from between your teeth where your toothbrush can’t reach. Dentists suggest flossing at least once a day to prevent cavities and gum disease. If traditional flossing is difficult, consider using:

Water flossers
Interdental brushes
Floss picks

3. Rinse with Mouthwash for Extra Protection

Using an antibacterial mouthwash helps reduce plaque, prevents bad breath, and protects against gum disease. Look for a fluoride-based or alcohol-free mouthwash, especially if you have sensitive gums.

Tip: Rinse for 30 seconds after brushing and flossing for best results.

4. Eat a Tooth-Friendly Diet

What you eat significantly impacts your oral health. Dentists recommend incorporating the following foods into your diet:

Dairy products (milk, cheese, yogurt) to strengthen enamel.
Crunchy fruits and vegetables (apples, carrots) to naturally clean teeth.
Nuts and seeds for essential minerals like calcium and phosphorus.
Green tea for its antibacterial properties.

Avoid excessive consumption of sugary snacks, acidic beverages, and sticky candies, which can erode enamel and lead to cavities.

5. Stay Hydrated and Limit Sugary Drinks

Drinking plenty of water helps wash away food particles and bacteria, keeping your mouth fresh and clean. Limit soda, sports drinks, and coffee, as they can stain teeth and contribute to decay.

Pro Tip: If you drink sugary or acidic beverages, use a straw to minimize direct contact with your teeth.

6. Replace Your Toothbrush Regularly

A worn-out toothbrush is ineffective at cleaning your teeth. Dentists recommend replacing your toothbrush every 3-4 months or sooner if the bristles are frayed. Using an electric toothbrush can also improve plaque removal.

7. Schedule Regular Dental Checkups

No matter how diligent your oral hygiene routine is, visiting your dentist every six months is crucial for professional cleanings and early detection of dental issues. Regular checkups can help prevent cavities, gum disease, and even serious health conditions linked to poor oral health.

8. Protect Your Teeth While Playing Sports

If you engage in contact sports, wearing a custom-fitted mouthguard can protect your teeth from injuries and fractures. This simple preventive measure can save you from costly dental treatments.

9. Avoid Smoking and Tobacco Products

Smoking and tobacco use are major contributors to gum disease, tooth loss, and oral cancer. If you’re looking for another reason to quit, your oral health is a great motivation. Talk to your dentist about resources to help you quit.

10. Teach Kids Good Oral Hygiene Habits Early

Children should learn proper oral hygiene habits from a young age. Encourage them to:

Brush their teeth with fluoride toothpaste.
Floss regularly.
Visit the dentist every six months.
Avoid excessive sweets and sugary drinks.

Setting a strong foundation for oral health can prevent future dental issues and ensure a lifetime of healthy smiles.

Conclusion

This National Dentist Day, take the opportunity to improve your oral care routine by following these expert tips. Good oral hygiene isn’t just about having a bright smile—it’s also essential for overall health and well-being. Show appreciation for your dentist by prioritizing your dental health and scheduling your next checkup.

For personalized dental care advice, consult a professional at SecondMedic, where expert guidance helps you maintain optimal oral health.