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Published on: May 31, 2021
1 minute read
By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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Sleep and Performance: The Silent Driver of Workplace Success

In India’s fast-paced digital work culture, sleep has quietly become one of the most overlooked pillars of productivity. While caffeine, deadlines, and long screen hours dominate the modern office routine, quality sleep remains the true driver of performance, creativity, and emotional balance.

According to NITI Aayog’s 2024 Health & Productivity Report, sleep deprivation affects nearly 68% of Indian professionals, leading to fatigue, anxiety, and reduced focus - a direct hit to workplace performance.

The Science of Sleep and Productivity

Sleep isn’t just rest - it’s restoration.
During sleep, the brain processes memory, repairs cells, balances hormones, and regulates emotional control.
Without enough of it, cognitive efficiency drops by up to 40%, as shown in a Statista 2024 workplace wellness survey.

Employees who get adequate sleep display:

Better problem-solving abilities
Faster reaction times
Improved emotional regulation
Higher motivation and engagement

In contrast, chronic sleep deprivation leads to irritability, errors, poor concentration, and slower learning.

Sleep and Mental Health at Work

Work stress and poor sleep form a vicious cycle.
Prolonged stress raises cortisol levels - which interferes with the body’s ability to fall and stay asleep. In turn, lack of sleep increases anxiety and depression risk.

A FICCI-EY 2024 study found that professionals sleeping less than 6 hours a night reported 25% lower job satisfaction and 31% higher burnout than those sleeping 7–8 hours.

Sleep directly impacts mental health, which in turn affects workplace collaboration, leadership, and creativity.

SecondMedic’s Approach to Sleep Wellness

SecondMedic offers digital solutions that integrate teleconsultations, AI-based sleep tracking, and stress management programs - empowering individuals to build better rest habits.

Key components include:

Sleep Consultations: Online sessions with wellness experts to identify causes of poor sleep (stress, diet, or screen habits).
AI Sleep Tracker: Monitors sleep patterns and provides actionable recommendations.
Mindfulness Sessions: Guided relaxation and breathing techniques to improve sleep quality.
Hormonal & Fatigue Tests: Diagnostic packages to rule out medical causes like thyroid imbalance or sleep apnea.

SecondMedic’s holistic model blends technology and medical expertise to restore the most vital aspect of health - restorative sleep.

Corporate Wellness and Productivity

Forward-thinking organizations are now investing in corporate sleep wellness programs as part of their employee health initiatives.
A Deloitte India 2024 report shows that sleep-related wellness initiatives can increase productivity by 25% and reduce absenteeism.

SecondMedic partners with companies to provide:

Sleep and stress assessments
Online wellness consultations
Customized fatigue and burnout prevention workshops

The result? Healthier employees, fewer sick days, and a happier, more focused workforce.

How to Improve Sleep and Performance

Here are actionable steps professionals can take:

Set a Sleep Routine: Go to bed and wake up at consistent times.
Avoid Screens Before Bed: Blue light disrupts melatonin production.
Limit Caffeine & Alcohol: Both affect sleep quality if consumed late.
Exercise Regularly: Light evening walks promote better sleep.
Use Sleep Tools: Track your rest cycles with digital apps like SecondMedic’s AI sleep tracker.

Consistency, not duration alone, determines sleep quality.

The Link Between Sleep and Leadership

Leaders who prioritize rest make clearer decisions and foster more empathetic workplaces.
A rested mind is a resilient mind - capable of innovation, strategic thinking, and conflict resolution.

In contrast, chronic fatigue impairs judgment and emotional control, two critical traits for leadership success.

India’s Shift Toward Sleep-Aware Work Culture

As the wellness movement grows, Indian organizations are embracing sleep as a strategic asset.
Tech firms, healthcare companies, and startups are partnering with wellness platforms like SecondMedic to integrate sleep-focused employee programs.

This cultural shift reflects a global realization - productivity is not about working longer but resting smarter.

Conclusion

Sleep is not a passive activity - it’s the foundation of high performance.
By prioritizing rest, India’s professionals can unlock sharper focus, better mental health, and sustainable productivity.

With SecondMedic’s sleep and wellness programs, individuals and organizations alike can harness the true potential of healthy sleep - the silent, powerful driver of success.

Book your sleep health consultation today at www.secondmedic.com

References

NITI Aayog – Health & Productivity Report 2024
FICCI-EY – Corporate Wellness in India 2024
Statista – Sleep & Workplace Efficiency Study India 2024
Deloitte India – Employee Wellness Trends 2024
ABDM – Ayushman Bharat Digital Mission (Sleep & Wellness) – https://abdm.gov.in

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