Call / Whatsapp
+918447748545

Published on: May 31, 2021
1 minute read
By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

Read Blog

Lipid Profile Test – Normal Range and Risks

Keeping your heart healthy isn’t just about staying active or eating green veggies. It also means knowing what’s going on inside your body—especially your cholesterol levels. One of the best ways to track this is through a lipid profile test.

If you’re wondering what this test means, what the numbers should be, and what risks you face if they're abnormal—this blog is for you.

Let’s dive into lipid profile test – normal range and risks in easy and clear language.

What Is a Lipid Profile Test?

A lipid profile test is a blood test that measures the amount of fat (lipids) in your blood. These lipids include different types of cholesterol and triglycerides.

The test helps evaluate your risk of heart disease, stroke, and clogged arteries.

What Does the Lipid Profile Test Measure?

A complete lipid profile usually measures:

Total Cholesterol – the overall amount of cholesterol in your blood
LDL (Low-Density Lipoprotein) – the “bad” cholesterol that can block arteries
HDL (High-Density Lipoprotein) – the “good” cholesterol that protects your heart
Triglycerides – a type of fat that provides energy but can cause heart issues in high amounts

Sometimes, the test also calculates VLDL and a cholesterol/HDL ratio to better assess your health risks.

Lipid Profile – Normal Range

Understanding what your numbers mean is key. Here are the recommended normal ranges:

Test Component	Normal Range
Total Cholesterol	Less than 200 mg/dL
LDL (Bad Cholesterol)	Less than 100 mg/dL
HDL (Good Cholesterol)	40 mg/dL or more (men), 50+ (women)
Triglycerides	Less than 150 mg/dL

Note: Values may vary slightly depending on labs and age. Always consult your doctor for interpretation.

Why Is This Test Important?

High cholesterol usually shows no symptoms. That’s why it's called a silent threat.

Your arteries may slowly get clogged without you knowing it, increasing the risk of:

Heart attacks
Strokes
Peripheral artery disease
High blood pressure

A lipid profile gives an early warning so you can make timely changes to protect your heart.

Risks of Abnormal Lipid Profile

Here’s what happens when the results are not in the normal range:

High LDL Cholesterol

Builds plaque in your arteries
Increases risk of heart attack or stroke

Low HDL Cholesterol

Reduces protection for your heart
Makes it easier for bad cholesterol to stick to artery walls

High Triglycerides

Can lead to pancreatitis and diabetes
Often linked with obesity and poor lifestyle

High Total Cholesterol

General risk marker for cardiovascular diseases

Causes of High Cholesterol or Triglycerides

Unhealthy diet (high in fried, fatty, and sugary foods)
Lack of physical activity
Smoking and alcohol consumption
Obesity
Diabetes or thyroid problems
Genetic/family history of high cholesterol

How to Improve Your Lipid Profile Naturally

If your test results are abnormal, you don’t always need medicine right away. Often, small changes in your lifestyle can bring big improvements.

Eat a Heart-Healthy Diet

Choose whole grains, fruits, vegetables, and lean proteins
Avoid processed food, red meat, and fried items
Include omega-3 rich foods like fish, flaxseeds, and walnuts

Exercise Regularly

30 minutes of walking, yoga, cycling, or swimming at least 5 days a week

Quit Smoking & Limit Alcohol

These habits lower HDL and increase LDL

Maintain a Healthy Weight

Losing even 5–10% of body weight can improve lipid levels

How and When to Take the Lipid Profile Test

When to Take:

Once every 12 months for adults above 30
More often if you have heart disease, diabetes, obesity, or a family history

Fasting Required?

Yes, you should fast for 8–12 hours before giving the blood sample for the most accurate results.

Can I Get This Test at Home?

Yes! Platforms like SecondMedic.com offer home sample collection for the Lipid Profile Test, powered by trusted labs like Thyrocare.

You just book the test online, and a technician collects the sample from your doorstep. Results are available digitally within 24–48 hours.

Total cholesterol over 240 mg/dL, LDL over 160 mg/dL, and triglycerides over 200 mg/dL are considered high-risk levels.

Conclusion

A lipid profile test is a simple yet powerful tool that gives deep insights into your heart health. Knowing the normal range and understanding the risks of abnormal levels can help you take control early and live a longer, healthier life.

Stay proactive about your health. Book a lipid profile test – normal range and risks checkup today and make heart-smart choices.

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.