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Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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Health Problems Linked to Excessive Caffeine Intake: When Too Much Becomes Harmful

Caffeine is one of the most widely consumed stimulants in the world. Found in coffee, tea, energy drinks and many soft drinks, it is often used to improve alertness and combat fatigue. While moderate caffeine consumption can be safe for most people, understanding the health problems linked to excessive caffeine intake is important, especially as daily consumption levels continue to rise in India.

Urban lifestyles, long working hours and increased reliance on energy drinks have made caffeine overconsumption a growing public health concern.

How Caffeine Works in the Body

Caffeine stimulates the central nervous system by blocking adenosine, a chemical responsible for promoting sleep and relaxation.

This results in:

increased alertness
faster heart rate
heightened mental activity

However, overstimulation places stress on multiple body systems.

What Is Considered Excessive Caffeine Intake?

According to WHO and global health guidelines:

up to 400 mg per day is considered safe for most healthy adults

Excessive intake occurs when:

multiple caffeinated beverages are consumed daily
energy drinks are used frequently
caffeine is consumed late in the day

Many people unknowingly exceed safe limits.

Nervous System Overstimulation

Excess caffeine overstimulates the brain.

Common symptoms include:

restlessness
nervousness
tremors
irritability

Chronic overstimulation can worsen stress and reduce emotional stability.

Anxiety and Panic Symptoms

Caffeine increases adrenaline release.

This can:

trigger anxiety attacks
worsen panic disorder
increase feelings of unease

ICMR mental health studies note caffeine as a common trigger for anxiety symptoms in sensitive individuals.

Sleep Disruption and Insomnia

Sleep is one of the first systems affected.

Excessive caffeine:

delays sleep onset
reduces deep sleep
shortens total sleep duration

Even caffeine consumed 6–8 hours before bedtime can impair sleep quality.

Impact on Heart Health

High caffeine intake affects the cardiovascular system.

Possible effects include:

increased heart rate
palpitations
irregular heart rhythm

People with underlying heart conditions are particularly vulnerable.

Blood Pressure Elevation

Caffeine temporarily raises blood pressure.

Chronic excessive intake may:

worsen hypertension
increase cardiovascular risk

NFHS-5 data highlights rising hypertension prevalence in India, making caffeine moderation important.

Digestive System Problems

Caffeine stimulates stomach acid production.

This can cause:

acidity
heartburn
gastritis
bloating

People with sensitive digestion may experience symptoms even at lower doses.

Dependency and Withdrawal Symptoms

Regular high intake leads to caffeine dependence.

Withdrawal symptoms include:

headaches
fatigue
irritability
difficulty concentrating

Dependence reinforces overconsumption cycles.

Effect on Bone Health

Excessive caffeine:

increases calcium loss through urine
may affect bone density over time

This is particularly concerning for older adults and women.

Dehydration and Electrolyte Imbalance

Caffeine has a mild diuretic effect.

High intake without adequate hydration may lead to:

dehydration
muscle cramps
fatigue

Hot climates increase this risk.

Impact on Blood Sugar and Metabolism

Caffeine affects glucose metabolism.

Excessive intake:

worsens insulin sensitivity
increases stress hormone release

This may increase diabetes risk when combined with poor lifestyle habits.

Energy Drinks and Hidden Risks

Energy drinks often contain:

very high caffeine levels
added sugar
stimulants

Lancet reports associate energy drink overuse with heart rhythm disturbances and metabolic stress.

High-Risk Groups

Certain individuals should be especially cautious:

people with anxiety disorders
those with heart disease
pregnant women
individuals with sleep disorders

Safe limits may be lower for these groups.

Signs You May Be Consuming Too Much Caffeine

Warning signs include:

frequent palpitations
chronic insomnia
persistent anxiety
digestive discomfort
reliance on caffeine to function

These signals indicate the need for reduction.

How to Reduce Caffeine Intake Safely

Effective strategies include:

gradual reduction rather than abrupt stopping
switching to decaffeinated options
avoiding caffeine after mid-afternoon
improving sleep and nutrition

Small steps prevent withdrawal symptoms.

Healthier Alternatives for Energy

Better ways to improve energy include:

adequate sleep
balanced meals
hydration
regular physical activity

These support sustained energy without overstimulation.

Role of Preventive Health Awareness

Preventive healthcare focuses on:

identifying lifestyle triggers
reducing dependency habits

NITI Aayog highlights lifestyle modification as key to non-communicable disease prevention.

Long-Term Health Consequences of Ignoring Excess Intake

Chronic caffeine overuse increases risk of:

sleep disorders
anxiety and mood issues
heart rhythm problems
digestive disorders

These conditions often develop gradually.

Conclusion

The health problems linked to excessive caffeine intake extend beyond temporary jitters or sleep loss. Chronic overconsumption strains the nervous system, disrupts sleep, affects heart rhythm, worsens anxiety and impacts digestion and metabolism. While caffeine can be enjoyed safely in moderation, recognising personal limits and maintaining balance is essential for long-term health. Listening to early warning signs and adopting healthier energy habits can prevent serious health consequences.

References

World Health Organization (WHO) – Caffeine Intake and Health Guidelines
Indian Council of Medical Research (ICMR) – Nutrition and Mental Health Studies
National Family Health Survey (NFHS-5) – Hypertension and Lifestyle Risk Data
Lancet – Energy Drinks, Caffeine and Cardiovascular Effects
NITI Aayog – Preventive Health and Lifestyle Modification Reports
Statista – Caffeine Consumption Trends in India

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