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Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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Virtual Second Opinion Services India: Making Medical Decisions Safer, Smarter, and More Accurate

Healthcare decisions can be overwhelming, especially when dealing with serious diagnoses, complex treatment options, or long-term health conditions. In India, where diagnostic variability and specialist availability differ across regions, seeking a second medical opinion has become essential for clarity and confidence. Virtual second opinion services India allow patients to consult top specialists online, review diagnoses, validate reports, and confirm treatment plans without traveling long distances.

SecondMedic has emerged as a trusted platform for virtual second opinions, connecting users with experienced specialists across cardiology, oncology, neurology, orthopedics, nephrology, endocrinology, and other medical fields. These services empower patients with accurate information and reduce the risk of misdiagnosis or unnecessary treatments.

Why Second Opinions Are Becoming Important in India

According to WHO, nearly 20-30% of medical errors globally stem from misdiagnoses. In India, disparities in medical access and diagnostic quality can make it harder for patients to rely on a single opinion-especially for complex or high-risk conditions.

Patients seek second opinions for:

Cancer diagnosis
Cardiac issues (blockages, angioplasty recommendations)
Orthopedic surgeries
Neurological disorders
Kidney and liver conditions
Autoimmune diseases
Rare or chronic illnesses

A second opinion ensures that treatment decisions are well-informed and evidence-based.

How Virtual Second Opinion Services Work

Virtual second opinion platforms like SecondMedic make the process simple and accessible.

Steps include:

Uploading medical reports, scans, prescriptions, and lab results.
Selecting the specialty or condition.
AI tools help summarize and organize the case.
A specialist reviews the case in detail.
The patient receives a written report or video consultation explaining the recommendations.
Follow-up guidance is provided when needed.

This digital-first approach saves time and helps patients receive expert evaluations from anywhere in India.

Key Benefits of Virtual Second Opinions

1. Access to Top Specialists

Patients can connect with some of India's best doctors without needing to visit major metro hospitals.

2. Prevention of Misdiagnosis

A fresh review reduces the risk of incorrect or incomplete diagnoses.

3. Verification of Treatment Plans

Before committing to surgery or long-term therapy, patients receive reassurance and clarity.

4. Time and Cost Savings

Virtual reviews eliminate travel, long waiting lines, and high hospital consultation fees.

5. Emotional Confidence

Patients and families gain peace of mind through expert validation of medical decisions.

SecondMedic ensures case reviews are thorough, unbiased, and personalized.

Use Cases Where Second Opinions Make a Big Difference

Oncology

Cancer diagnoses often require multi-specialty inputs. Virtual tumor board reviews help patients choose the right treatment path.

Cardiology

Heart conditions like blockages, angioplasty recommendations, or arrhythmia management require accurate evaluations.

Orthopedics

Joint replacement or spine surgery recommendations often need second validation to avoid unnecessary procedures.

Neurology

Conditions like epilepsy, stroke, or movement disorders benefit from deeper case review.

Chronic Illnesses

Diabetes, hypertension, kidney disease, and thyroid disorders require long-term management strategies.

Why Virtual Second Opinion Is Better Than In-Person for Many Patients

More specialist availability
Faster review times
Ability to compare multiple expert opinions
Digital access to consolidated medical records
Better accommodation of busy schedules
Suitable for rural patients with limited access to tertiary care hospitals

Digital second opinions remove geographic barriers completely.

The Role of Technology in Second Opinions

AI enhances the clarity and accuracy of second opinions by:

Pre-sorting medical documents
Highlighting abnormalities in lab results
Summarizing doctor notes
Identifying missing tests
Flagging potential medical risks

SecondMedic combines AI insights with top specialist expertise, resulting in stronger, data-backed recommendations.

Challenges in India’s Traditional Second Opinion System

Long wait times at major hospitals
Difficulty obtaining complete medical records
Travel to metro cities
Lack of specialized doctors in Tier 2/3 cities
Inconsistent diagnostic quality

Virtual second opinion services solve all of these pain points.

Future Outlook

Virtual medical reviews will continue growing with:

AI-powered case analysis
Integration with electronic health records (EHRs)
Multi-specialty collaborative boards
Predictive diagnostics
Global doctor networks

SecondMedic aims to lead this space by offering deeper, faster, and more accurate medical reassessments.

Conclusion

Virtual second opinion services India empower patients to make informed, safe, and confident healthcare decisions. By connecting users with top specialists and leveraging AI-driven insights, SecondMedic ensures that every major medical choice is backed by expertise and clarity. This is especially valuable for complex diagnoses, chronic conditions, and surgical recommendations.

To request a virtual second opinion, visit www.secondmedic.com

References

WHO - Misdiagnosis data and clinical errors
NITI Aayog - Digital health transformation reports
ABDM - Digital health records and interoperability
Statista - Telehealth adoption in India
Lancet & NEJM - Studies on second opinions
SecondMedic clinical team insights

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