• Published on: Apr 04, 2020
  • 2 minute read
  • By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

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Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola 

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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Importance of Hydration for Organs: How Water Keeps the Body Functioning

Water is the most essential nutrient for human survival, yet it is often the most neglected. Every cell, tissue and organ in the body depends on adequate hydration to function properly. The importance of hydration for organs becomes clear when we understand how even mild dehydration can disrupt critical physiological processes.

In India’s climate, with high temperatures and humidity in many regions, dehydration risk is especially high, making conscious hydration a daily health priority.

 

Why Water Is Vital for the Human Body

The human body is made up of approximately 60 percent water. This water:

  • transports nutrients and oxygen
     

  • regulates body temperature
     

  • removes waste products
     

  • supports metabolic reactions
     

Without adequate hydration, organ systems begin to struggle.

 

Hydration and Kidney Health

The kidneys are among the most hydration-dependent organs.

Proper hydration:

  • helps kidneys filter blood efficiently
     

  • flushes out toxins and waste
     

  • reduces risk of kidney stones
     

Chronic dehydration forces kidneys to concentrate urine, increasing strain and long-term damage risk. According to Indian Council of Medical Research data, dehydration is a major contributor to kidney stone formation in India.

 

Brain Function and Hydration

The brain is highly sensitive to hydration levels.

Even mild dehydration can cause:

  • headaches
     

  • difficulty concentrating
     

  • memory issues
     

  • irritability
     

Studies published in the Lancet show that dehydration negatively affects cognitive performance and mood, even before thirst becomes noticeable.

 

Heart and Circulatory System

Hydration plays a critical role in cardiovascular health.

Adequate water intake:

  • maintains blood volume
     

  • supports smooth circulation
     

  • reduces strain on the heart
     

Dehydration thickens blood, making the heart work harder and potentially increasing the risk of low blood pressure, dizziness and cardiovascular stress.

 

Digestive System and Hydration

Water supports digestion at every stage.

It helps:

  • break down food
     

  • absorb nutrients
     

  • prevent constipation
     

Chronic low water intake is linked to digestive discomfort, bloating and poor gut motility.

 

Liver Function and Detoxification

The liver relies on water to:

  • metabolise nutrients
     

  • detoxify harmful substances
     

  • support metabolic balance
     

Inadequate hydration slows detoxification processes and increases metabolic strain.

 

Muscle and Joint Health

Muscles and joints contain significant water content.

Hydration:

  • prevents muscle cramps
     

  • supports joint lubrication
     

  • reduces injury risk
     

Dehydrated muscles fatigue faster and recover more slowly.

 

Skin as an Organ and Hydration

The skin is the body’s largest organ.

Adequate hydration:

  • maintains skin elasticity
     

  • supports barrier function
     

  • reduces dryness and irritation
     

While water alone is not a cure for skin problems, chronic dehydration worsens skin health.

 

Hydration and Immune Function

Water supports immune health by:

  • enabling transport of immune cells
     

  • aiding removal of toxins
     

  • supporting lymphatic circulation
     

WHO recognises hydration as a foundational element of immune system support.

 

Effects of Dehydration on Multiple Organs

Dehydration affects the body systemically.

Common effects include:

  • fatigue
     

  • dizziness
     

  • reduced urine output
     

  • dark-coloured urine
     

  • dry mouth and eyes
     

Severe dehydration can lead to organ failure if untreated.

 

Why Dehydration Often Goes Unnoticed

Many people confuse thirst with hunger or fatigue.

Risk factors include:

  • busy work schedules
     

  • excessive caffeine intake
     

  • high temperatures
     

  • inadequate fluid intake
     

By the time thirst is felt, dehydration has already begun.

 

Hydration Needs Vary by Individual

Water requirements depend on:

  • age
     

  • body size
     

  • physical activity
     

  • climate
     

  • health conditions
     

General guidelines suggest 2–3 litres daily for adults, but individual needs may vary.

 

Hydration and Chronic Disease Prevention

Proper hydration supports prevention of:

  • kidney disease
     

  • urinary tract infections
     

  • constipation
     

  • heat-related illness
     

NITI Aayog and WHO highlight hydration as a basic preventive health measure.

 

Best Practices for Staying Hydrated

Effective hydration strategies include:

  • drinking water regularly throughout the day
     

  • increasing intake during heat or physical activity
     

  • consuming water-rich foods such as fruits and vegetables
     

  • limiting sugary and caffeinated beverages
     

Consistency matters more than quantity in a single sitting.

 

Signs You May Need More Water

Watch for:

  • frequent fatigue
     

  • headaches
     

  • dry skin
     

  • reduced urination
     

  • poor concentration
     

These are early indicators of dehydration.

 

Role of Preventive Health Awareness

Preventive healthcare focuses on simple daily habits.

Hydration:

  • costs nothing
     

  • supports every organ
     

  • reduces disease risk
     

Small habits deliver large long-term benefits.

 

When to Seek Medical Advice

Consult a healthcare professional if experiencing:

  • persistent dehydration symptoms
     

  • kidney or urinary issues
     

  • dizziness or fainting
     

  • chronic fatigue
     

Underlying conditions may require medical evaluation.

 

Conclusion

The importance of hydration for organs cannot be overstated. Water supports kidney filtration, brain function, heart circulation, digestion, immunity and overall metabolic balance. Even mild dehydration disrupts organ performance and increases health risks over time. In busy modern lifestyles, consciously prioritising daily hydration is one of the simplest and most effective ways to protect vital organs and maintain long-term health. Consistent water intake is not just a habit—it is a foundation for organ health and wellbeing.

 

References

  • Indian Council of Medical Research (ICMR) – Hydration and Kidney Health Studies
  • World Health Organization (WHO) – Water Intake and Health Guidelines
  • National Family Health Survey (NFHS-5) – Nutrition and Lifestyle Data
  • Lancet – Hydration, Cognitive Function and Organ Health Research
  • NITI Aayog – Preventive Healthcare and Lifestyle Recommendations
  • Statista – Global Hydration and Health Trends

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