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Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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Neurobion Forte: Benefits for Nerve Health and Vitamin B Deficiency

Vitamin deficiencies are a common but often overlooked health issue. Among them, vitamin B deficiency is particularly significant because of its direct impact on nerve function, energy metabolism and overall neurological health. Neurobion Forte is a widely used vitamin B-complex supplement designed to address these deficiencies and support nerve health.

Understanding how Neurobion Forte works and when it is beneficial helps individuals make informed decisions about their nutritional and neurological wellbeing.

What Is Neurobion Forte?

Neurobion Forte is a combination supplement containing essential B vitamins, primarily:

vitamin B1 (thiamine)
vitamin B6 (pyridoxine)
vitamin B12 (cobalamin)

These vitamins play a vital role in nerve signal transmission, energy production and maintenance of the nervous system.

Why Vitamin B Is Essential for Nerve Health

B vitamins are crucial for:

nerve impulse transmission
myelin sheath formation
energy metabolism in nerve cells

Deficiency can impair nerve function, leading to discomfort and neurological symptoms.

Common Causes of Vitamin B Deficiency

Vitamin B deficiency may occur due to:

inadequate dietary intake
poor absorption
chronic illnesses
long-term medication use
alcohol misuse

Vegetarians and elderly individuals are particularly at risk of vitamin B12 deficiency.

Symptoms of Vitamin B Deficiency

Early symptoms may include:

fatigue
weakness
numbness or tingling in hands and feet
poor concentration

If untreated, deficiency may progress to more serious neurological problems.

How Neurobion Forte Supports Nerve Health

Supports Nerve Repair

Vitamin B12 contributes to nerve regeneration and maintenance of nerve fibres.

Improves Nerve Signal Transmission

Vitamin B1 supports proper nerve impulse conduction.

Reduces Nerve Irritation

Vitamin B6 helps regulate neurotransmitter synthesis, reducing nerve-related discomfort.

Supports Energy Metabolism

B vitamins help convert food into energy, supporting overall nerve and muscle function.

Role of Neurobion Forte in Nerve Pain

Nerve pain caused by vitamin deficiency may present as:

burning sensation
tingling
numbness
shooting pain

In such cases, correcting the deficiency through supplementation may help relieve symptoms over time.

Conditions Where Neurobion Forte Is Commonly Used

Neurobion Forte may be prescribed or recommended in cases such as:

peripheral neuropathy
diabetic neuropathy (as supportive care)
nutritional deficiency-related nerve symptoms
general weakness associated with vitamin B deficiency

It is not a painkiller but supports underlying nutritional correction.

Importance of Medical Guidance

While vitamin supplements are widely available, inappropriate or excessive use may cause side effects.

Medical guidance ensures:

correct diagnosis
appropriate dosage
monitoring of response

Self-medication should be avoided, especially for long-term use.

Diet and Vitamin B Intake

Dietary sources of B vitamins include:

whole grains
legumes
dairy products
eggs
meat and fish

Balanced nutrition remains the foundation of vitamin sufficiency.

Who May Benefit Most from Neurobion Forte?

Individuals who may benefit include:

those with confirmed vitamin B deficiency
people with nerve-related symptoms
elderly individuals with poor nutrient absorption
individuals with restricted diets

Supplementation should complement dietary improvement.

Possible Side Effects and Precautions

When taken as advised, Neurobion Forte is generally well tolerated.

However:

excessive vitamin B6 intake may cause nerve symptoms
allergic reactions are rare but possible

Always follow professional advice.

How Long Does It Take to See Benefits?

Improvement depends on:

severity of deficiency
duration of symptoms
individual health status

Some people notice symptom improvement within weeks, while others require longer support.

Neurobion Forte and Overall Wellbeing

Correcting vitamin B deficiency supports:

nerve health
energy levels
cognitive function
overall vitality

Supplementation is most effective when combined with healthy lifestyle habits.

Conclusion

Neurobion Forte plays an important role in managing vitamin B deficiency and supporting nerve health. By supplying essential B vitamins, it helps restore nerve function, reduce deficiency-related symptoms and improve overall neurological wellbeing. While it can be highly beneficial when deficiency is present, its use should always be guided by medical advice to ensure safety and effectiveness. Balanced nutrition, early diagnosis and appropriate supplementation together form the foundation of healthy nerve function.

References

World Health Organization (WHO) – Micronutrients and Neurological Health
Indian Council of Medical Research (ICMR) – Nutrient Deficiency Guidelines
National Institute of Nutrition (NIN) – Vitamin B and Nerve Function Reports
Lancet Neurology – Vitamin Deficiency and Neuropathy Studies
Indian Journal of Clinical Nutrition – Vitamin B Supplementation Researc
Statista – Dietary Supplement Usage Trends

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