Call
+918447748545

Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

Read Blog

Lifestyle Disease Prevention India: Protecting Health Through Proactive Care

Lifestyle diseases, also known as non-communicable diseases (NCDs), have become one of India’s most pressing health challenges. Conditions such as diabetes, hypertension, obesity, heart disease, thyroid disorders, fatty liver, and high cholesterol now affect millions-often starting at younger ages compared to previous generations. According to the Indian Council of Medical Research (ICMR), NCDs account for more than 60 percent of deaths in India. The good news: most lifestyle diseases are preventable with awareness, screening, and timely intervention.

SecondMedic supports a national shift from reactive to preventive healthcare through early detection, nutrition planning, lifestyle improvement, and chronic risk monitoring.

Why Lifestyle Disease Prevention Matters in India

1. Rising NCD Burden

Rapid urbanization, longer working hours, stress, and processed foods have accelerated lifestyle disease growth.

2. Younger Population at Risk

More Indians in their 20s and 30s are developing prediabetes, fatty liver, and high cholesterol.

3. Silent Disease Progression

Many conditions show no symptoms in the early stages.

4. High Long-Term Medical Cost

Treatment for advanced diabetes or heart disease is expensive compared to prevention.

5. Impact on Productivity

Organizations face rising health-related absenteeism and reduced performance.

Prevention is not optional-it is a necessity.

Major Lifestyle Diseases in India

1. Diabetes & Prediabetes

India has over 10 crore diabetics, with many unaware of their condition.

2. Hypertension

Known as the “silent killer,” it increases risk for heart attack and stroke.

3. Heart Disease

India sees one of the highest premature heart attack rates globally.

4. Obesity & Metabolic Syndrome

Poor diet and inactivity contribute to dangerous fat accumulation.

5. Fatty Liver Disease

Highly common even among non-alcoholic individuals.

6. Thyroid Disorders

Thyroid imbalances affect metabolism, weight, and mental health.

7. Stress & Sleep Disorders

Impact emotional stability and long-term health.

SecondMedic offers preventive screenings tailored for each of these risk areas.

Early Detection Through Preventive Health Checkups

Preventive checkups help detect abnormalities before they turn into chronic disease.

SecondMedic’s packages include:

CBC
Lipid profile
HbA1c
Thyroid panel
Liver function tests
Kidney profile
Cardiac markers
Vitamin D & B12
Hormone tests
ECG

These tests provide a comprehensive health snapshot.

Lifestyle Disease Prevention Strategies

1. Nutrition Management

A healthy diet is the foundation of prevention.
SecondMedic dietitians design personalized nutrition plans based on:

Age
Weight
Activity
Medical history

2. Regular Physical Activity

Movement reduces blood sugar, strengthens the heart, and improves metabolism.

3. Stress Management

Chronic stress increases cortisol, causing diabetes and weight gain.
SecondMedic offers:

Online mental health counselling
Anxiety management
Sleep routines

4. Avoiding Tobacco & Alcohol

These significantly increase risk of cancer, fatty liver, and heart disease.

5. Healthy Weight Maintenance

Targeted routines help maintain optimal BMI and waist circumference.

6. Adequate Sleep

Poor sleep leads to hormonal imbalance and weak immunity.

7. Regular Health Checkups

Monitoring every 6-12 months helps track changes early.

Technology in Lifestyle Disease Prevention

India’s digital health ecosystem supports smarter prevention through:

Wearables
Fitness trackers
AI-based risk prediction
Digital symptom assessment
Remote monitoring devices

SecondMedic integrates these tools for continuous care.

Why SecondMedic for Lifestyle Disease Prevention

1. Comprehensive Screening

All major biomarkers, organ function tests, and metabolic indicators.

2. Expert Interpretation

Doctors analyze results and provide actionable insights.

3. Personalized Health Plans

Nutrition + fitness + lifestyle guidance.

4. Continuous Monitoring

Follow-ups ensure long-term success.

5. Integrated Telemedicine Support

Patients can speak to specialists anytime.

Conclusion

Lifestyle disease prevention India is crucial for improving long-term health and reducing the national burden of chronic diseases. Through early screening, targeted intervention, better nutrition, exercise routines, and continuous monitoring, individuals can dramatically reduce their risk. SecondMedic offers a complete ecosystem of preventive healthcare to help Indians stay healthy and proactive.

To begin your preventive health journey, visit www.secondmedic.com

References

ICMR - India NCD burden
WHO - Global NCD prevention guidelines
Statista - Lifestyle disease trends in India
NITI Aayog - Preventive health model
SecondMedic preventive care insights

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.