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Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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Why Recurring Sore Throat Can Be a Serious Issue

A sore throat is a common complaint. Most of us experience it during seasonal changes, after a cold, or when we catch the flu. But what if your sore throat keeps coming back again and again? While many people dismiss it as a minor irritation, a recurring sore throat can actually signal more serious health issues that require proper attention.

What is a recurring sore throat?

A recurring sore throat refers to repeated or persistent throat discomfort that comes back multiple times in a year or lasts longer than usual. Normally, a viral sore throat improves within a week. If the problem lingers beyond 10 days or returns frequently, it falls into the category of chronic or recurring sore throat.

Why is it serious?

Undiagnosed infections
A single sore throat from a virus is not concerning. But if bacterial infections like strep throat keep coming back, they may damage the throat and spread to other parts of the body if untreated.
Inflammation and tissue damage
Constant irritation from allergies or acid reflux can harm the delicate tissues of the throat. Over time, this may affect your voice and overall throat function.
Underlying medical conditions
Recurring sore throat can be linked to issues like gastroesophageal reflux disease (GERD), allergies, tonsil problems, or immune system weakness. In some cases, it may also be an early warning sign of more serious diseases such as tumors.
Complications
Recurrent infections can lead to abscesses around the tonsils, ear infections, or sinus problems. Inadequate or repeated antibiotic use can also cause resistance.
Impact on daily life
A constant sore throat affects your eating, speaking, sleeping, and quality of life. It leads to repeated doctor visits, discomfort, and stress.

Common causes of recurring sore throat

Bacterial infections like strep throat or chronic tonsillitis
Viral infections that linger or reactivate
Allergies that trigger postnasal drip and throat irritation
Acid reflux or GERD causing stomach acid to irritate the throat
Environmental irritants such as smoke, dust, and pollution
Mouth breathing during sleep due to nasal blockage
Immune weakness making you prone to repeated infections

Warning signs to watch for

You should never ignore these symptoms if they accompany a recurring sore throat:

Sore throat lasting longer than 2–3 weeks
Difficulty swallowing or breathing
Lump or swelling in the throat or neck
Persistent hoarseness or voice changes
Unexplained weight loss
Blood in saliva or phlegm
Fever with night sweats

These are red flags that need immediate medical evaluation.

How lab tests help

Lab tests play a critical role in finding out why you have a recurring sore throat. Some useful investigations include:

Throat swab or culture to identify bacterial infections
Rapid antigen test for strep for quick diagnosis
Complete Blood Count (CBC) to detect infection or immune problems
CRP and ESR to check inflammation
Allergy tests to identify triggers like dust or pollen
Thyroid function tests to rule out thyroid-related throat problems
Reflux evaluation if GERD is suspected
Immune status tests if infections are unusually frequent

Through SecondMedic/Thyrocare, these tests can be arranged easily, giving you faster results and treatment planning.

Treatment and prevention

The treatment of recurring sore throat depends on its cause:

Bacterial infections are treated with antibiotics prescribed by a doctor. Completing the full course is essential.
Viral infections usually require rest, hydration, and symptom management.
Acid reflux can be controlled with lifestyle changes like avoiding late meals, reducing spicy foods, and medications if required.
Allergies can be managed by identifying and avoiding triggers, along with prescribed medicines.
Tonsil problems may require surgical removal if infections are frequent and severe.

Preventive steps include:

Staying hydrated
Avoiding smoking and exposure to polluted air
Maintaining good throat hygiene
Managing acid reflux through diet and posture
Strengthening immunity with balanced nutrition and rest

When to see a doctor

If you suffer from frequent sore throats or if your symptoms come with any red flags, consult a healthcare professional without delay. Early evaluation prevents complications and ensures better outcomes.

Conclusion

Recurring sore throat is more than just an inconvenience. It is often a signal from your body that something is not right. Identifying the cause early and undergoing the right tests can help you recover faster and avoid long-term damage.

At SecondMedic, you can access lab tests, doctor consultations, and treatment guidance all in one place. Don’t ignore a sore throat that keeps returning — take charge of your health today and book your tests with SecondMedic/Thyrocare for accurate results and expert support.

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