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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Dairy-Free Options for All: A Comprehensive SecondMedic Guide for India

Dairy consumption has long been a part of Indian dietary culture, but rising awareness of digestive health, metabolic concerns, acne, inflammation and lactose intolerance has encouraged many individuals to explore dairy-free alternatives. India is experiencing a significant shift toward plant-based nutrition as people prioritise preventive health, gut comfort and personalised dietary choices.

SecondMedic’s nutrition experts emphasise evidence-based, dairy-free patterns that support digestion, hormonal balance, metabolic stability and overall wellbeing. This guide explores the best dairy-free options in India, their health benefits and how they integrate into daily preventive care.

Why Dairy-Free Eating Is Growing in India

1. Rising Lactose Intolerance

According to ICMR Digestive Health Trends, a high percentage of Indian adults experience lactose intolerance due to decreased lactase enzyme activity.

Common symptoms include:

Bloating
Gas
Acidity
Diarrhoea
Skin flare-ups

Dairy-free alternatives eliminate these discomforts.

2. Skin & Hormonal Concerns

Dairy may influence acne, PCOS symptoms and inflammation in certain individuals.

3. Improved Digestibility

Many plant-based options are easier on the gut and reduce inflammation.

4. Increasing Nutrition Awareness

NFHS-5 highlights micronutrient deficiencies-including Vitamin D and B12-leading people to choose fortified dairy-free alternatives.

Popular Dairy-Free Options in India

1. Almond Milk

Rich in Vitamin E and naturally low in calories.
Ideal for smoothies, coffee and cereal.

2. Soy Milk

High in protein and often fortified with calcium.
Great for cooking and baking.

3. Oat Milk

Creamy texture, high in soluble fibre.
Excellent for lattes and desserts.

4. Coconut Milk

Rich flavour, suitable for Indian curries and smoothies.

5. Nut-Based Yoghurt

Cashew and almond curds have become widely available.
Probiotic varieties support gut health.

6. Tofu & Plant-Based Paneer

Excellent protein source for vegetarians.

7. Lactose-Free Dairy

For those who prefer traditional taste without digestive discomfort.

Nutritional Benefits of Dairy-Free Options

1. Reduced Inflammation

Studies in Lancet Public Health show improved gut comfort among individuals switching to dairy-free diets.

2. Hormonal Balance

Plant-based alternatives help regulate insulin, estrogen and androgen patterns-especially valuable for PCOS and thyroid care.

3. Weight Management

Lower calorie load and better digestibility support metabolic health.

4. Allergy-Friendly Choice

A safe option for individuals sensitive to casein or whey proteins.

How to Build a Balanced Dairy-Free Diet

Ensure calcium intake:

Choose fortified plant milks.

Include plant proteins:

Tofu, dals, nuts and seeds.

Add healthy fats:

Ground flaxseed, chia and almonds.

Combine traditional and modern options:

Oat milk chai, tofu tikka, nut curd raita.

SecondMedic’s AI nutrition scoring helps evaluate vitamin density and carbohydrate load for optimal choices.

Dairy-Free Meal Examples

Breakfast

• Oats cooked with almond milk
• Fruit + chia seeds + nuts

Lunch

• Millet khichdi with tofu
• Vegetable salad with tahini dressing

Snack

• Coconut yoghurt with berries

Dinner

• Stir-fry vegetables with tofu
• Whole-grain roti + plant-based curd

Conclusion

Dairy-free options provide flexible, nutritious and preventive pathways for individuals across India. Whether motivated by digestive comfort, metabolic health, ethical choices or personal preference, dairy-free alternatives support long-term wellness. SecondMedic helps individuals evaluate and incorporate dairy-free nutrition through expert consultations, AI-based analysis and personalised dietary planning.

References

• ICMR Digestive Health & Lactose Intolerance Study
• National Family Health Survey (NFHS-5) - Nutrition & Dietary Patterns
• NITI Aayog - Plant-Based Nutrition & Preventive Wellness Framework
• WHO Guidelines on Healthy Dietary Alternatives
• Lancet Public Health - Dairy-Free Diets & Inflammation Research
• Statista India Plant-Based Food Market Analysis
• EY-FICCI Food Innovation & Health Trends Report

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