• Published on: Nov 13, 2020
  • 1 minute read
  • By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

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Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Digestive

Digestive System Disorders: Common Causes, Symptoms, and Prevention Tips

The digestive system plays a vital role in overall health by breaking down food, absorbing nutrients and eliminating waste. When this system does not function properly, it can lead to discomfort, poor nutrition and chronic illness. Digestive system disorders are increasingly common due to modern lifestyles, dietary habits and stress. Understanding their causes, symptoms and prevention strategies is essential for maintaining long-term gut health.

Public health research shows that a large proportion of adults experience digestive symptoms at some point in their lives, yet many delay seeking care until problems become severe.

 

What Are Digestive System Disorders?

Digestive system disorders are conditions that affect:

  • the oesophagus
     

  • stomach
     

  • intestines
     

  • liver
     

  • pancreas
     

  • gallbladder
     

They may be temporary or chronic and range from mild functional issues to serious inflammatory or structural diseases.

 

Common Digestive System Disorders

Acid Reflux and GERD

Gastroesophageal reflux disease (GERD) occurs when stomach acid flows back into the oesophagus.

Symptoms include:

  • heartburn
     

  • chest discomfort
     

  • sour taste in mouth
     

  • difficulty swallowing
     

Long-term reflux can damage the oesophagus if untreated.

 

Irritable Bowel Syndrome (IBS)

IBS is a functional bowel disorder.

Symptoms include:

  • abdominal pain
     

  • bloating
     

  • diarrhoea or constipation
     

  • alternating bowel habits
     

Stress and diet often trigger symptoms.

 

Constipation

Constipation involves infrequent or difficult bowel movements.

Causes include:

  • low fibre intake
     

  • dehydration
     

  • sedentary lifestyle
     

Chronic constipation affects comfort and gut function.

 

Diarrhoea

Diarrhoea results from rapid bowel movements.

Common causes include:

  • infections
     

  • food intolerance
     

  • medication side effects
     

Persistent diarrhoea may lead to dehydration and nutrient loss.

 

Peptic Ulcer Disease

Ulcers are sores in the stomach or intestinal lining.

Symptoms include:

  • burning stomach pain
     

  • nausea
     

  • bloating
     

They are often linked to infections or long-term medication use.

 

Inflammatory Bowel Disease (IBD)

IBD includes conditions like Crohn’s disease and ulcerative colitis.

Symptoms include:

  • chronic diarrhoea
     

  • abdominal pain
     

  • weight loss
     

  • fatigue
     

IBD requires long-term medical management.

Common Symptoms of Digestive Disorders

Digestive system disorders often present with:

  • abdominal pain or cramps
     

  • bloating and gas
     

  • nausea or vomiting
     

  • constipation or diarrhoea
     

  • heartburn
     

  • unexplained weight changes
     

Symptoms may fluctuate and worsen with stress or poor diet.

 

Causes of Digestive System Disorders

Poor Dietary Habits

Diets high in:

  • processed foods
     

  • refined sugars
     

  • unhealthy fats
     

strain the digestive system and alter gut microbiota.

 

Stress and Mental Health

Chronic stress affects gut-brain communication, worsening digestive symptoms.

 

Infections

Bacterial, viral or parasitic infections disrupt gut function.

 

Food Intolerances

Lactose, gluten or other intolerances cause digestive distress.

 

Sedentary Lifestyle

Lack of physical activity slows digestion and bowel movement.

 

Medication Use

Certain medications irritate the stomach lining or alter gut flora.

 

Who Is at Higher Risk?

People at increased risk include:

  • individuals with poor diet
     

  • those under chronic stress
     

  • older adults
     

  • people with family history of gut disease
     

  • individuals with sedentary lifestyles
     

Early lifestyle correction reduces risk significantly.

 

Diagnosis of Digestive Disorders

Evaluation may include:

  • medical history
     

  • physical examination
     

  • blood tests
     

  • stool tests
     

  • imaging or endoscopy
     

Diagnosis depends on symptom severity and duration.

 

Treatment Approaches

Medical Management

Treatment varies by condition and may include:

  • acid suppressants
     

  • anti-inflammatory medications
     

  • probiotics
     

  • antibiotics when needed
     

 

Dietary Modifications

  • increase fibre intake
     

  • limit trigger foods
     

  • eat regular meals
     

  • avoid excessive alcohol
     

Diet plays a central role in gut health.

 

Lifestyle Changes

  • manage stress
     

  • exercise regularly
     

  • stay hydrated
     

  • maintain sleep routine
     

Healthy habits support digestive function.

 

Prevention Tips for Digestive Health

Eat a Balanced Diet

Include fruits, vegetables, whole grains and lean proteins.

 

Stay Hydrated

Water supports digestion and prevents constipation.

 

Manage Stress

Mindfulness and relaxation techniques improve gut-brain balance.

 

Be Physically Active

Movement stimulates bowel activity and gut motility.

 

Avoid Smoking and Excess Alcohol

These irritate the digestive tract and worsen symptoms.

 

Seek Early Medical Advice

Early care prevents complications and chronic disease.

 

Long-Term Impact of Ignoring Digestive Problems

Untreated digestive disorders may lead to:

  • nutrient deficiencies
     

  • chronic inflammation
     

  • poor quality of life
     

  • increased disease complications
     

Early intervention is more effective and less invasive.

 

When to Consult a Doctor

Medical advice is recommended if:

  • symptoms persist beyond weeks
     

  • pain is severe
     

  • blood appears in stool
     

  • unexplained weight loss occurs
     

Prompt evaluation ensures safe management.

 

Conclusion

Digestive system disorders are common but often underestimated health issues. Symptoms such as bloating, pain, constipation and heartburn may seem minor initially but can signal deeper problems if ignored. Understanding causes, recognising early symptoms and adopting preventive habits help protect digestive health. With timely care, balanced nutrition and healthy lifestyle choices, most digestive disorders can be effectively managed, allowing the digestive system to function smoothly and support overall wellbeing.

 

References

  • Indian Council of Medical Research (ICMR) – Digestive Health and Nutrition Reports

  • World Health Organization (WHO) – Digestive Disorders and Gut Health Guideline

  •  National Institute of Nutrition (NIN) – Dietary Fibre and Gut Health Researc

  •  Lancet – Gastrointestinal Disease and Prevention Studies

  •  Indian Journal of Gastroenterology – Digestive Disorder Research

  •  Statista – Digestive Health Trends and Lifestyle Factors

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