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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Monthly Field Day with Patients & Staff: Building Trust, Engagement, and Wellbeing

Healthcare is built on relationships. While diagnosis, treatment and technology are critical, the human connection between patients and healthcare staff remains central to healing and recovery. A Monthly Field Day with Patients & Staff is a thoughtful initiative designed to strengthen these relationships by creating opportunities for interaction outside routine clinical environments.

In today’s healthcare systems, patient engagement and staff wellbeing are recognised as essential components of quality care. Monthly field days provide a structured yet informal platform to support both.

What Is a Monthly Field Day with Patients & Staff?

A Monthly Field Day is a planned engagement event where patients and healthcare staff come together to participate in non-clinical activities. These events focus on:

interaction
wellbeing
communication
community-building

They are not medical appointments but shared experiences that promote trust and understanding.

Why Field Days Matter in Healthcare

Healthcare Is Emotionally Demanding

Patients often experience anxiety, fear and uncertainty. Staff face long hours, emotional stress and high responsibility. Field days offer a space for:

relaxed interaction
emotional connection
mutual understanding

This humanises care delivery.

Strengthening Patient–Staff Trust

Trust grows through:

open communication
shared experiences
consistent engagement

Field days reduce perceived barriers between patients and healthcare teams.

Benefits for Patients

Improved Comfort and Confidence

Patients feel more at ease when they know the people involved in their care beyond clinical roles.

Better Engagement in Care

Engaged patients are more likely to:

ask questions
follow care plans
attend follow-ups

This leads to improved health outcomes.

Emotional and Social Wellbeing

Social interaction, light activity and positive experiences support mental and emotional health, especially for patients with chronic conditions.

Benefits for Healthcare Staff

Reduced Burnout

Regular non-clinical engagement helps:

reduce emotional fatigue
restore motivation
improve job satisfaction

Stronger Team Relationships

Shared activities strengthen teamwork and communication among staff members.

Renewed Sense of Purpose

Seeing patients outside stressful clinical settings reinforces the meaningful impact of healthcare work.

Organisational Benefits

Enhanced Patient-Centered Culture

Field days reinforce values of empathy, accessibility and respect.

Improved Patient Satisfaction

Trust and familiarity contribute to better patient experiences and feedback.

Better Communication and Feedback

Informal settings encourage honest dialogue, helping organisations understand patient needs and expectations.

Activities Commonly Included in Field Days

Wellness Activities

gentle exercises
stretching or yoga
breathing sessions

Educational Interactions

health awareness talks
preventive care discussions
lifestyle guidance

Recreational and Social Activities

group games
creative sessions
interactive challenges

These activities promote joy, connection and inclusion.

Inclusivity and Accessibility

Effective field days are:

inclusive of different age groups
adaptable for physical limitations
culturally sensitive
welcoming and non-competitive

Inclusivity ensures meaningful participation for all.

Why Monthly Frequency Works Best

Monthly scheduling:

maintains continuity
builds long-term trust
prevents disengagement
supports gradual relationship building

Consistency transforms engagement into culture.

Evidence Supporting Engagement Initiatives

Research shows that:

patient engagement improves health outcomes
staff wellbeing reduces errors and burnout
relationship-based care enhances satisfaction

Global health frameworks emphasise people-centred care models.

Measuring the Impact of Field Days

Impact can be evaluated through:

patient feedback
staff engagement surveys
participation rates
qualitative testimonials

Regular assessment helps refine the program.

Implementing a Successful Monthly Field Day

Key elements include:

leadership support
clear objectives
simple, inclusive activities
consistent scheduling
feedback-driven improvement

Success depends on commitment rather than scale.

Long-Term Impact on Healthcare Culture

Over time, Monthly Field Days contribute to:

stronger trust
improved communication
better morale
enhanced care experience

They reinforce the idea that healthcare is a partnership between people.

Conclusion

A Monthly Field Day with Patients & Staff is more than an engagement activity—it is a meaningful investment in trust, wellbeing and human connection. By creating shared experiences beyond clinical settings, healthcare organisations strengthen relationships that directly influence care quality and satisfaction. In an environment often driven by efficiency and outcomes, monthly field days remind us that compassion, communication and community remain at the heart of effective healthcare.

References

World Health Organization (WHO) – People-Centred Care and Patient Engagement
Indian Council of Medical Research (ICMR) – Patient Experience and Care Quality Studie
Lancet – Patient–Provider Relationships and Health Outcomes
National Health Systems Resource Centre – Community Engagement in Healthcare
Indian Journal of Healthcare Management – Staff Wellbeing and Patient Satisfaction
Statista – Healthcare Engagement and Experience Trends

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