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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Health Risks of Irregular Eating Habits: How Skipping Meals Affects Your Body

Maintaining a balanced and consistent diet is essential for good health. However, modern lifestyles often lead to irregular eating patterns due to busy schedules, work stress and changing daily routines. Many people skip meals, eat late at night or consume food at inconsistent times.

Understanding the health risks of irregular eating habits is important for maintaining metabolic balance and overall wellbeing. Consistent meal timing plays a key role in supporting digestion, energy levels and long-term health.

What Are Irregular Eating Habits?

Irregular eating habits refer to inconsistent or unpredictable meal patterns.

Common examples include:

Skipping breakfast or other meals
Eating meals at varying times each day
Consuming large meals late at night
Frequently replacing meals with snacks

These habits may disrupt the body’s natural metabolic rhythm.

How the Body Regulates Eating Patterns

The human body follows internal biological rhythms that regulate hunger, metabolism and digestion.

When meals occur at consistent times, the digestive system prepares enzymes and hormones needed for efficient food processing.

Irregular eating patterns may interfere with these processes.

1. Disruption of Metabolism

Metabolism refers to the process by which the body converts food into energy.

Skipping meals or eating inconsistently may slow metabolic activity, making it harder for the body to regulate energy balance.

This disruption may contribute to metabolic disorders over time.

2. Increased Risk of Weight Gain

Although skipping meals may appear to reduce calorie intake, it often leads to overeating later in the day.

Large or late meals may increase calorie consumption and contribute to weight gain.

Irregular eating may also affect hormones that regulate appetite.

3. Digestive Problems

The digestive system functions best when meals occur at regular intervals.

Irregular eating may cause symptoms such as:

Acid reflux
Bloating
Indigestion
Stomach discomfort

Consistent meal timing helps maintain digestive balance.

4. Fluctuating Energy Levels

Skipping meals can lead to sudden drops in blood sugar levels.

Low blood sugar may cause symptoms such as:

Fatigue
Dizziness
Difficulty concentrating

Regular meals help maintain steady energy throughout the day.

5. Impact on Blood Sugar Control

Irregular eating patterns may disrupt glucose regulation.

Over time, inconsistent meal timing may increase the risk of insulin resistance and type 2 diabetes.

Maintaining stable blood sugar levels is important for metabolic health.

6. Nutritional Deficiencies

Skipping meals can reduce the intake of essential nutrients required for body function.

A balanced diet provides vitamins, minerals and other nutrients needed for immunity, metabolism and overall health.

Irregular eating habits may lead to nutritional imbalances.

Irregular Eating Habits in the Indian Context

In many urban areas of India, demanding work schedules and long commuting times often lead to irregular meal patterns.

Late-night eating, fast food consumption and skipped meals have become common among professionals and students.

These lifestyle patterns may increase the risk of metabolic and digestive health problems.

Promoting regular meal timing and balanced diets is essential for improving public health.

Tips to Maintain Healthy Eating Habits

Establish Regular Meal Times

Eating meals at consistent times each day helps regulate digestion and metabolism.

Do Not Skip Breakfast

Breakfast provides essential energy for starting the day and supports metabolic activity.

Plan Balanced Meals

Include a variety of foods such as:

Whole grains
Fruits and vegetables
Lean proteins
Healthy fats

Balanced nutrition supports overall health.

Avoid Late-Night Heavy Meals

Eating large meals close to bedtime may disrupt digestion and sleep.

Stay Hydrated

Adequate hydration supports digestion and nutrient absorption.

When to Seek Medical Advice

Consult a healthcare professional if irregular eating habits lead to:

Persistent digestive problems
Unexplained weight changes
Chronic fatigue
Blood sugar irregularities

Early intervention can help prevent long-term health complications.

Conclusion

Irregular eating habits may significantly impact metabolism, digestion and overall health. Skipping meals, inconsistent meal timing and late-night eating can disrupt the body’s natural rhythms and increase the risk of metabolic disorders.

Maintaining consistent meal schedules, balanced nutrition and healthy lifestyle habits can support digestive health and stable energy levels.

By adopting regular eating routines, individuals can improve metabolic balance and reduce the risk of long-term health complications.

Healthy eating patterns are a fundamental part of maintaining overall wellbeing and long-term health.

References

Indian Council of Medical Research – Nutrition and Dietary Guidelines
World Health Organization – Healthy Diet Recommendations
National Institute of Nutrition India – Balanced Meal Guidelines
Journal of Nutrition and Metabolism – Meal Timing Research
Lancet Global Health – Nutrition and Lifestyle Studies

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