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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Zincovit Tablets: Uses, Benefits, Dosage, and Side Effects Explained

Nutritional deficiencies are common in India due to irregular diets, stress, fast-paced lifestyles and increased health demands. Multivitamin supplements are often recommended to support overall health, immunity and energy levels. One commonly prescribed supplement is Zincovit tablets.

This comprehensive guide explains what Zincovit is, its uses, benefits, dosage recommendations and potential side effects.

What Are Zincovit Tablets?

Zincovit is a multivitamin and multimineral supplement that contains:

Zinc
Vitamin C
B-complex vitamins
Vitamin A
Vitamin D
Vitamin E
Selenium and other antioxidants

It is commonly prescribed to address nutritional deficiencies and support immune function.

Uses of Zincovit Tablets

Zincovit may be recommended for:

1. Nutritional Deficiencies

Helps replenish low vitamin and mineral levels due to poor diet or illness.

2. Weak Immunity

Zinc and vitamin C support immune system function.

3. Recovery After Illness

Often prescribed during recovery from infections, surgery or prolonged weakness.

4. Fatigue and Low Energy

B vitamins help improve energy metabolism.

5. Hair and Skin Health

Zinc and antioxidants may support healthy skin and hair.

Benefits of Zincovit Tablets

Immune Support

Zinc plays a vital role in immune cell function.

Antioxidant Protection

Vitamins C and E help reduce oxidative stress.

Improved Energy Levels

B-complex vitamins aid in converting food into energy.

Better Nutritional Balance

Supports individuals with dietary gaps.

Support During Stress

Stress can deplete nutrients; supplementation may help maintain balance.

Recommended Dosage

Adults: Usually one tablet daily after meals
Children: Only if prescribed by a pediatrician
Duration: As advised by healthcare professional

Do not exceed recommended dosage without medical guidance.

How to Take Zincovit

Take after food to prevent stomach irritation
Swallow whole with water
Avoid taking with high-calcium foods unless advised

Consistency improves effectiveness.

Possible Side Effects

Zincovit is generally well tolerated. However, some individuals may experience:

Nausea
Mild stomach discomfort
Metallic taste
Constipation or diarrhea (rare)

Severe allergic reactions are uncommon but require immediate medical attention.

Who Should Use Caution?

Consult a doctor before taking Zincovit if you have:

Kidney disorders
Liver disease
Thyroid problems
Known allergies to supplement components

Pregnant and breastfeeding women should seek medical advice before use.

Can Zincovit Be Taken Long-Term?

Short-term use for deficiency correction is common. Long-term use should be monitored by a healthcare provider to avoid excessive intake of certain vitamins or minerals.

Excess zinc intake may interfere with copper absorption if taken excessively over time.

Zincovit and Immunity in India

With increasing concern about immunity and viral infections, supplements containing zinc and antioxidants have gained popularity. However, supplements should complement — not replace — a balanced diet rich in:

Fruits
Vegetables
Whole grains
Protein sources

Healthy lifestyle habits remain essential.

When to Consult a Doctor

Seek medical advice if you experience:

Persistent fatigue
Recurrent infections
Unexplained weight loss
Severe weakness

These may indicate underlying medical conditions beyond nutritional deficiency.

Balanced Nutrition Still Matters

Supplements cannot substitute a healthy diet. Combine Zincovit with:

Proper hydration
Regular exercise
Adequate sleep
Stress management

This ensures overall wellness.

Conclusion

Zincovit tablets are widely used multivitamin supplements that support immunity, energy levels and overall nutritional balance. When taken in recommended doses, they are generally safe and beneficial for individuals with dietary deficiencies or increased nutritional needs.

However, supplements should be used responsibly and under medical guidance, especially for long-term use. Maintaining a healthy diet and lifestyle remains the foundation of good health.

If you are unsure whether Zincovit is right for you, consult a healthcare professional for personalized advice.

References

Indian Council of Medical Research – Nutrient Guidelines
World Health Organization – Micronutrient Recommendations
National Health Portal India – Supplement Safety
Journal of Clinical Nutrition – Zinc and Immunity Studies
National Institute of Nutrition India – Dietary Guidelines

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