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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Busting Nutrition Myths in India: An Evidence-Based Guide Powered by SecondMedic’s AI Health Guide

Nutrition misinformation has become increasingly common in India. From viral social media diets to generational food beliefs, many individuals struggle to separate fact from fiction. These myths can influence daily habits, delay proper treatment and contribute to the growing burden of lifestyle diseases.

SecondMedic’s AI Health Guide was designed to offer clarity. By analysing scientific literature, Indian dietary patterns and personal health inputs, it explains complex nutrition topics in a human-friendly, practical manner. This blog explores the most widespread nutrition myths in India and how an AI-enabled approach helps users make informed dietary decisions.

Why Nutrition Myths Persist in India

1. Cultural dietary traditions

Food practices often evolve through experience but not always through evidence. Certain long-held assumptions continue despite scientific updates.

2. Rise of viral misinformation

Millions of Indians search diet advice online daily, and misleading content spreads rapidly without expert review.

3. High prevalence of lifestyle diseases

ICMR and NFHS-5 highlight escalating rates of:

Diabetes
Obesity
Hypertension
PCOS
Thyroid disorders

The public seeks quick solutions, making myths appealing.

4. Limited access to qualified dietitians

Many people rely on hearsay or generic tips rather than personalised nutrition guidance.

SecondMedic’s AI Health Guide bridges this gap by offering accessible, evidence-backed explanations.

Myth 1: “Carbohydrates always lead to weight gain.”

Carbohydrates are not inherently harmful.
The problem lies in refined carbohydrates like white bread, sugary drinks and packaged snacks.

What the science says

Whole grains, millets, oats and fibre-rich carbs improve:

Gut health
Blood sugar regulation
Energy levels

Research in Lancet Public Health confirms that complex carbs support metabolic wellbeing.

AI Health Guide perspective

The system evaluates:

Activity level
Blood sugar trends
Dietary preferences

Then recommends the type and quantity of carbs suitable for the individual.

Myth 2: “Protein damages the kidneys.”

This is one of India’s most common misconceptions.

Clinical reality

Protein affects kidneys only in individuals with existing kidney disease.

NFHS-5 shows that most Indians do not meet their daily protein requirement.

Balanced approach

Safe protein sources:

Lentils
Paneer
Eggs
Tofu
Chicken
Fish

An AI-guided nutrition plan ensures intake matches needs and health conditions.

Myth 3: “All fats are unhealthy.”

Fats play essential roles in:

Hormone production
Brain function
Vitamin absorption

Good fats

Nuts and seeds
Olive oil
Flaxseed
Fatty fish

Harmful fats

Trans fats
Hydrogenated oils
Deep-fried packaged snacks

SecondMedic’s AI Health Guide analyses dietary logs to suggest healthier fat alternatives.

Myth 4: “Detox diets cleanse the body.”

Detox teas, juices and cleanses are popular but not scientifically validated.

Actual detoxification

The liver, kidneys and digestive system naturally remove toxins.

Risks of extreme detox diets

Fatigue
Digestive distress
Slow metabolism
Nutrient deficiencies

A sustainable alternative includes balanced meals, hydration and fibre-rich foods.

Myth 5: “Eating after 8 PM causes weight gain.”

Timing is not the primary factor.
Weight gain depends on:

Total calorie intake
Food quality
Portion control
Sleep-wake cycles

For shift workers or late diners, an AI-based guide personalises eating windows that match biological rhythms.

How AI Personalises Nutrition Guidance for India

The AI Health Guide adapts advice based on:

• Clinical inputs

Blood reports, symptoms, chronic conditions.

• Lifestyle signals

Sleep, activity, stress, work schedules.

• Cultural eating patterns

North Indian, South Indian, vegetarian, non-vegetarian diets.

• Personal health goals

Weight control, energy improvement, disease management.

This ensures that the guidance is not generic-it is tailored for real-life Indian scenarios.

How an AI Health Guide Supports Preventive Healthcare

1. Early risk identification

AI recognises patterns that may indicate:

Rising blood sugar
Nutrient deficiencies
Poor digestion
Inflammatory markers

2. Behavioural nudges

Small, realistic changes are suggested instead of extreme diet plans.

3. Improved health literacy

Users understand why certain foods are better choices.

4. Better medical support

Clear explanations enhance doctor and dietitian consultations.

Conclusion

Nutrition myths can lead individuals toward restrictive diets, nutrient deficiencies and misguided health decisions. With rising lifestyle diseases in India, accurate nutrition knowledge is essential. A scientific, personalised approach-supported by an AI Health Guide-helps individuals navigate misinformation confidently.

By combining evidence-based insights with individual dietary needs, SecondMedic’s AI-driven guidance empowers people to adopt sustainable, preventive and truly health-enhancing food habits.

References

• ICMR Indian Nutrition Profile & Dietary Science Study
• National Family Health Survey (NFHS-5) - Protein Intake & Micronutrient Data
• NITI Aayog - Preventive Health & Digital Nutrition Insights
• WHO Global Dietary Guidelines & Balanced Nutrition Framework
• Lancet Public Health - Carbohydrate Quality & Metabolic Health Studies
• Statista - India Digital Nutrition & Health Behaviour Analysis
• EY-FICCI - AI and Preventive Healthcare Consumer Report

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