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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Early Signs of a Weakened Immune System: Symptoms You Should Not Ignore

The immune system is the body’s natural defense mechanism against infections, bacteria and viruses. It works continuously to identify and eliminate harmful pathogens that may threaten health. However, when the immune system becomes weakened, the body becomes more vulnerable to illness and infections.

Recognizing the early signs of a weakened immune system is essential for maintaining overall health and preventing serious complications. Early awareness allows individuals to make lifestyle changes and seek medical advice if necessary.

Understanding the Immune System

The immune system is composed of:

White blood cells
Antibodies
Lymph nodes
Bone marrow
The spleen and thymus

These components work together to detect and destroy harmful organisms. When immunity is compromised, this protective mechanism becomes less effective.

1. Frequent Infections

One of the most common signs of weakened immunity is experiencing frequent infections.

These may include:

Recurrent colds
Sinus infections
Ear infections
Respiratory illnesses

If infections occur repeatedly or take longer than usual to recover, it may indicate reduced immune strength.

2. Persistent Fatigue

Constant tiredness despite adequate sleep may signal an underlying immune imbalance.

When the immune system is weakened, the body uses more energy to fight potential threats, leading to prolonged fatigue.

3. Slow Wound Healing

A healthy immune system supports tissue repair and healing.

Cuts, bruises or minor injuries that take longer than usual to heal may indicate weakened immune function.

Delayed healing may also increase infection risk.

4. Digestive Problems

A significant portion of the immune system is located in the gastrointestinal tract.

Digestive symptoms such as:

Frequent diarrhea
Bloating
Constipation

may reflect imbalance in gut health and immunity.

5. Frequent Allergies or Sensitivities

A weakened immune system may overreact to harmless substances, causing allergic reactions.

Symptoms may include:

Sneezing
Skin irritation
Food sensitivities

Maintaining immune balance helps regulate these responses.

6. Recurring Fever

Frequent low-grade fever may occur when the body is constantly attempting to fight infections.

This may indicate ongoing immune stress.

7. Increased Susceptibility to Stress

Chronic stress significantly affects immune function.

Stress hormones such as cortisol may suppress immune responses, making the body more vulnerable to illness.

Common Causes of Weak Immunity

Several lifestyle and health factors can weaken the immune system:

Poor nutrition
Lack of sleep
Chronic stress
Sedentary lifestyle
Smoking or excessive alcohol consumption
Chronic illnesses

Identifying these factors is important for improving immune health.

Strengthening the Immune System Naturally

Maintain a Balanced Diet

Consume foods rich in:

Vitamin C
Vitamin D
Zinc
Antioxidants

Fruits, vegetables, nuts and whole grains support immune function.

Prioritize Sleep

Adequate sleep allows the immune system to repair and regenerate.

Adults should aim for 7–8 hours of sleep daily.

Stay Physically Active

Moderate physical activity improves circulation and supports immune response.

Regular exercise also reduces stress levels.

Manage Stress

Practices such as meditation, breathing exercises and relaxation techniques help regulate stress hormones.

Maintain Hygiene

Simple habits like handwashing reduce exposure to harmful pathogens.

Weak Immunity in the Indian Context

In India, factors such as nutritional deficiencies, pollution exposure and high stress levels contribute to weakened immunity among many individuals.

Public health initiatives increasingly emphasize balanced nutrition, vaccination and healthy lifestyle habits to improve immune resilience.

When to Consult a Doctor

Seek medical advice if you experience:

Frequent infections
Persistent fatigue
Unexplained weight loss
Recurrent fever
Slow healing wounds

Medical evaluation may identify underlying health conditions affecting immunity.

Conclusion

Recognizing the early signs of a weakened immune system is essential for protecting long-term health. Symptoms such as frequent infections, fatigue and slow wound healing may indicate that the body’s defense mechanisms need support.

By adopting healthy lifestyle habits, maintaining balanced nutrition and managing stress effectively, individuals can strengthen immune function and reduce the risk of illness.

Listening to the body’s warning signals and seeking timely medical guidance ensures better health outcomes and improved wellbeing.

A strong immune system is the foundation of a healthy life.

References

Indian Council of Medical Research – Immunity and Nutrition Reports
World Health Organization – Immune Health Guidelines
National Institute of Nutrition India – Dietary Recommendations
Journal of Clinical Immunology – Immune System Research
Lancet Global Health – Public Health and Immunity Studies

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