Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Why Recurring Sore Throat Can Be a Serious Issue

A sore throat is a common complaint. Most of us experience it during seasonal changes, after a cold, or when we catch the flu. But what if your sore throat keeps coming back again and again? While many people dismiss it as a minor irritation, a recurring sore throat can actually signal more serious health issues that require proper attention.

What is a recurring sore throat?

A recurring sore throat refers to repeated or persistent throat discomfort that comes back multiple times in a year or lasts longer than usual. Normally, a viral sore throat improves within a week. If the problem lingers beyond 10 days or returns frequently, it falls into the category of chronic or recurring sore throat.

Why is it serious?

Undiagnosed infections
A single sore throat from a virus is not concerning. But if bacterial infections like strep throat keep coming back, they may damage the throat and spread to other parts of the body if untreated.
Inflammation and tissue damage
Constant irritation from allergies or acid reflux can harm the delicate tissues of the throat. Over time, this may affect your voice and overall throat function.
Underlying medical conditions
Recurring sore throat can be linked to issues like gastroesophageal reflux disease (GERD), allergies, tonsil problems, or immune system weakness. In some cases, it may also be an early warning sign of more serious diseases such as tumors.
Complications
Recurrent infections can lead to abscesses around the tonsils, ear infections, or sinus problems. Inadequate or repeated antibiotic use can also cause resistance.
Impact on daily life
A constant sore throat affects your eating, speaking, sleeping, and quality of life. It leads to repeated doctor visits, discomfort, and stress.

Common causes of recurring sore throat

Bacterial infections like strep throat or chronic tonsillitis
Viral infections that linger or reactivate
Allergies that trigger postnasal drip and throat irritation
Acid reflux or GERD causing stomach acid to irritate the throat
Environmental irritants such as smoke, dust, and pollution
Mouth breathing during sleep due to nasal blockage
Immune weakness making you prone to repeated infections

Warning signs to watch for

You should never ignore these symptoms if they accompany a recurring sore throat:

Sore throat lasting longer than 2–3 weeks
Difficulty swallowing or breathing
Lump or swelling in the throat or neck
Persistent hoarseness or voice changes
Unexplained weight loss
Blood in saliva or phlegm
Fever with night sweats

These are red flags that need immediate medical evaluation.

How lab tests help

Lab tests play a critical role in finding out why you have a recurring sore throat. Some useful investigations include:

Throat swab or culture to identify bacterial infections
Rapid antigen test for strep for quick diagnosis
Complete Blood Count (CBC) to detect infection or immune problems
CRP and ESR to check inflammation
Allergy tests to identify triggers like dust or pollen
Thyroid function tests to rule out thyroid-related throat problems
Reflux evaluation if GERD is suspected
Immune status tests if infections are unusually frequent

Through SecondMedic/Thyrocare, these tests can be arranged easily, giving you faster results and treatment planning.

Treatment and prevention

The treatment of recurring sore throat depends on its cause:

Bacterial infections are treated with antibiotics prescribed by a doctor. Completing the full course is essential.
Viral infections usually require rest, hydration, and symptom management.
Acid reflux can be controlled with lifestyle changes like avoiding late meals, reducing spicy foods, and medications if required.
Allergies can be managed by identifying and avoiding triggers, along with prescribed medicines.
Tonsil problems may require surgical removal if infections are frequent and severe.

Preventive steps include:

Staying hydrated
Avoiding smoking and exposure to polluted air
Maintaining good throat hygiene
Managing acid reflux through diet and posture
Strengthening immunity with balanced nutrition and rest

When to see a doctor

If you suffer from frequent sore throats or if your symptoms come with any red flags, consult a healthcare professional without delay. Early evaluation prevents complications and ensures better outcomes.

Conclusion

Recurring sore throat is more than just an inconvenience. It is often a signal from your body that something is not right. Identifying the cause early and undergoing the right tests can help you recover faster and avoid long-term damage.

At SecondMedic, you can access lab tests, doctor consultations, and treatment guidance all in one place. Don’t ignore a sore throat that keeps returning — take charge of your health today and book your tests with SecondMedic/Thyrocare for accurate results and expert support.

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