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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Monthly Health Survey via SecondMedic App: A Smarter Approach to Preventive Healthcare

Healthcare is gradually shifting from reactive treatment to proactive prevention. Traditional health models rely heavily on annual checkups or medical visits only after symptoms become severe. However, many chronic and lifestyle-related conditions develop silently over time. The Monthly Health Survey via the SecondMedic App addresses this gap by enabling continuous health monitoring and early risk identification.

According to the Indian Council of Medical Research (ICMR) and NITI Aayog, early detection and preventive care are critical to reducing the growing burden of non-communicable diseases in India. Digital health tools play a key role in achieving this shift.

What Is the Monthly Health Survey?

The Monthly Health Survey is a structured digital questionnaire delivered through the SecondMedic App. It captures key health indicators such as:

recurring symptoms
lifestyle habits
stress and sleep patterns
nutrition and activity levels
chronic condition markers

By repeating the survey monthly, subtle health trends become visible.

Why Monthly Health Tracking Matters

Annual Checkups Miss Gradual Changes

Many health issues develop slowly. Annual tests may appear normal while symptoms quietly progress between visits.

Monthly surveys:

detect early warning signs
capture symptom patterns
identify lifestyle-related risks

Health Is Dynamic, Not Static

Stress, sleep, diet and activity fluctuate monthly. Regular tracking reflects real-life health variation more accurately than isolated tests.

How the Monthly Health Survey Works

Each month, users answer a guided set of questions related to:

physical symptoms
mental wellbeing
lifestyle behaviours
known medical conditions

The app analyses responses to highlight:

risk trends
symptom persistence
areas needing attention

This structured approach simplifies health awareness.

Key Health Areas Covered

Symptom Monitoring

Persistent fatigue, headaches, breathlessness or digestive issues are tracked across months to identify patterns.

Lifestyle Risk Factors

The survey captures:

sedentary behaviour
sleep quality
stress levels
dietary habits

These factors strongly influence long-term health outcomes.

Chronic Disease Indicators

For individuals with diabetes, hypertension or thyroid conditions, monthly monitoring supports better disease control and early escalation.

Role in Preventive Healthcare

Preventive healthcare focuses on stopping disease before complications arise.

Monthly health surveys support prevention by:

identifying risks early
prompting timely consultations
supporting lifestyle modification
reducing emergency care needs

WHO and NITI Aayog both highlight digital monitoring as a cornerstone of preventive health systems.

Benefits for Individuals

Early Awareness

Users become aware of health changes before symptoms become severe.

Empowered Decision-Making

Access to regular health insights encourages proactive lifestyle choices.

Reduced Anxiety

Structured tracking reduces uncertainty and fear about unexplained symptoms.

Better Doctor Consultations

Survey data provides doctors with a clearer health history, improving consultation quality.

Benefits for Chronic Care Management

For chronic conditions, consistency is key.

Monthly surveys help:

track symptom control
identify early deterioration
support medication adherence
reduce complications

This continuous loop improves long-term outcomes.

Data-Driven Personalised Care

The survey supports personalised care by:

tailoring recommendations
prioritising high-risk users
guiding preventive interventions

This approach moves healthcare from generic advice to individualised guidance.

Privacy and Responsible Use

Health data is sensitive.

The survey framework is designed to:

collect only relevant information
support medical decision-making
maintain confidentiality

Responsible data use builds trust and long-term engagement.

Why Digital Surveys Are Effective in India

India’s healthcare challenges include:

large population
limited access to preventive care
high lifestyle disease burden

Digital surveys overcome barriers by:

being accessible anywhere
requiring minimal time
enabling large-scale preventive monitoring

This scalability makes them highly impactful.

Integration with Broader Health Ecosystems

Monthly health surveys work best when integrated with:

medical consultations
diagnostic services
preventive checkups
digital health records

Integration ensures continuity of care.

Long-Term Impact on Healthcare Outcomes

Over time, regular health tracking leads to:

earlier diagnoses
reduced hospitalisations
better chronic disease control
lower healthcare costs
improved quality of life

Lancet studies show that continuous monitoring significantly improves preventive outcomes.

Who Should Use a Monthly Health Survey?

adults over 30
individuals with chronic conditions
people with high-stress lifestyles
those focusing on preventive health
corporate wellness participants

Proactive monitoring benefits all age groups.

Conclusion

The Monthly Health Survey via the SecondMedic App represents a modern, preventive approach to healthcare. By capturing health trends regularly rather than annually, it empowers individuals to act early, supports doctors with better insights and reduces the burden of advanced disease. In an era where prevention is the most effective medicine, monthly health surveys transform awareness into action and data into healthier lives.

References

Indian Council of Medical Research (ICMR) – Preventive Healthcare and Early Detection Report
NITI Aayog – Digital Health and Preventive Care Strateg
World Health Organization (WHO) – Digital Health Monitoring Guideline
Lancet – Preventive Healthcare and Continuous Monitoring Studies
National Health Authority – Digital Health Mission Indi
Statista – Digital Health App Adoption Trends India

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