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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Replace Junk with Subscription Snack Packs: A Practical Approach to Preventive Nutrition in India

India is witnessing a growing shift toward healthier eating habits, yet junk food consumption continues to rise across all age groups. According to ICMR and NFHS-5 data, high-calorie packaged snacks, sugary beverages and deep-fried foods contribute significantly to obesity, diabetes and cardiovascular risk. Replacing these items with nutritious snack alternatives is one of the simplest yet most effective steps toward preventive wellness.

Subscription snack packs offer a structured, convenient and affordable way to transition from unhealthy snacking to balanced nutrition. SecondMedic promotes this approach as part of a broader preventive health ecosystem that focuses on long-term behavioural change rather than temporary diets.

Why Indians are Choosing Healthy Snack Subscriptions

1. Convenience in fast-paced lifestyles

Urban and semi-urban households often depend on quick, accessible snacks to keep up with busy schedules. Healthy subscription packs bring pre-portioned nutrition directly to the doorstep.

2. Rising health concerns

India now ranks among the world’s highest in:

Diabetes prevalence
Childhood obesity
Hypertension
High cholesterol

Replacing junk food is essential for reducing these long-term risks.

3. Growing awareness of clean eating

People are moving toward:

Low-sugar
Low-sodium
High-fibre
High-protein
Non-fried
snack alternatives.

4. Cost-effectiveness

Contrary to belief, balanced snack packs cost less than repeated purchases of unhealthy packaged foods.

What Makes Subscription Snack Packs Healthier?

Healthy snack packs are curated for balanced nutrition:

• Nuts and seeds

Rich in healthy fats, fibre and minerals.

• Millet-based snacks

Low GI, nutrient-dense and suitable for diabetics.

• Dried fruits

Provide natural sweetness without refined sugar.

• Roasted chana and legumes

Excellent plant-based protein sources.

• Low-sugar bars

Made from oats, dates, nuts and seeds.

• Whole-grain crackers

Better than refined flour biscuits.

• Herbal teas

Support digestion and relaxation.

These snacks reduce cravings while supporting metabolic health.

Why Junk Food Needs Replacement

• High in trans fats

Linked to heart disease and inflammation.

• Excess sugar

Promotes insulin resistance, weight gain and metabolic syndrome.

• Refined flour

Lacks fibre and elevates glucose rapidly.

• Additives & preservatives

May contribute to long-term digestive and metabolic issues.

• Instant cravings

Junk foods trigger overeating by stimulating dopamine pathways.

Replacing them with healthier options breaks this cycle.

How Subscription Snack Packs Support Preventive Healthcare

1. Portion control

Pre-measured servings reduce the risk of overeating.

2. Balanced nutrition

Snack packs provide fibre, healthy fats and micronutrients missing from typical Indian diets.

3. Reduced decision fatigue

Users do not have to search for healthy options daily.

4. Behavioural consistency

Weekly or monthly packs promote long-term habit formation.

5. Support for chronic disease management

Especially helpful for:

Diabetes
PCOS
Thyroid issues
Heart disease

SecondMedic integrates snack guidance into dietitian consultations and AI-driven nutrition analysis.

The Role of AI Health Guide in Smarter Snacking

SecondMedic’s AI Health Guide provides:

• Calorie and nutrient insights

Evaluates daily intake based on user habits.

• Snack recommendations

Based on medical conditions, preferences and goals.

• Craving pattern analysis

Identifies triggers for unhealthy eating.

• Personalised preventive plans

Aligns snacking habits with heart, gut and metabolic health.

This makes snack substitution easier and more sustainable.

How to Transition from Junk Food to Healthy Snack Packs

Step 1: Identify your biggest cravings

Sugary, salty, crunchy or fried?

Step 2: Find healthier alternatives

For example:

Replace chips ? roasted makhana
Replace sweets ? dates + nuts
Replace biscuits ? whole-grain crackers

Step 3: Use subscription packs for structure

Pre-curated boxes guide behaviour change.

Step 4: Track progress

Energy levels improve within 2-4 weeks.

Step 5: Build long-term habits

Consistency leads to metabolic improvement.

Conclusion

Replacing junk food with subscription snack packs is an effective and convenient step toward preventive wellness in India. By combining healthier ingredients, balanced nutrition and consistent delivery, subscription packs help individuals make better choices daily. With expert guidance and AI-driven insights from SecondMedic, these changes become sustainable, personalised and impactful for long-term health.

References

• ICMR - Dietary Patterns & Junk Food Consumption Study
• NFHS-5 - Nutrition Deficiencies & Lifestyle Data India
• NITI Aayog - Preventive Health & Nutrition Strategy
• WHO - Healthy Diet & Non-Communicable Disease Guidelines
• Lancet - Consumption Patterns & Cardiometabolic Risk
• Statista India - Healthy Snacking Trends
• EY-FICCI - Consumer Behaviour Toward Preventive Health

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