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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Impact of Air Pollution on Human Health: Risks, Effects and Prevention

Air pollution has become one of the most serious public health challenges worldwide. In India, rapid urbanisation, vehicle emissions, industrial activity and seasonal factors contribute to high pollution levels, especially in metropolitan cities. Understanding the impact of air pollution on human health is essential because exposure to polluted air significantly increases the risk of chronic illness and premature death.

According to the World Health Organization, air pollution is responsible for millions of premature deaths globally each year. Studies published in The Lancet highlight India as one of the countries most affected by air quality-related health burdens.

What Is Air Pollution?

Air pollution occurs when harmful substances such as:

particulate matter (PM2.5 and PM10)
nitrogen dioxide
sulfur dioxide
ozone
carbon monoxide

accumulate in the atmosphere at unsafe levels.

Among these, PM2.5 particles are particularly dangerous because they are small enough to penetrate deep into the lungs and bloodstream.

Respiratory Health Effects

The most immediate and visible impact of air pollution is on the lungs.

Short-Term Effects

coughing
throat irritation
wheezing
shortness of breath

Long-Term Effects

chronic bronchitis
asthma worsening
reduced lung capacity
chronic obstructive pulmonary disease (COPD)

Children and elderly individuals are especially vulnerable.

Impact on Heart Health

Air pollution does not only affect the lungs. Fine particles enter the bloodstream and trigger inflammation.

Long-term exposure increases risk of:

hypertension
heart attack
stroke
atherosclerosis

ICMR reports show cardiovascular diseases remain a leading cause of mortality in India, with pollution being a significant contributing factor.

Impact on Immune System

Constant exposure to polluted air weakens the immune response.

This leads to:

frequent respiratory infections
slower recovery from illness
increased susceptibility to viral diseases

Pollution also increases systemic inflammation.

Effect on Children’s Health

Children are particularly vulnerable because:

their lungs are still developing
they breathe more air relative to body weight
they spend time outdoors

Long-term exposure may reduce lung growth and increase asthma risk.

Impact on Pregnant Women and Infants

Research published in Lancet indicates that high pollution exposure during pregnancy increases risk of:

low birth weight
premature birth
developmental complications

Protecting pregnant women from pollution exposure is critical.

Air Pollution and Cancer Risk

Prolonged exposure to air pollution increases the risk of lung cancer.

WHO classifies outdoor air pollution as a carcinogen.

Mental Health and Cognitive Impact

Emerging research suggests pollution may contribute to:

cognitive decline
mood disorders
reduced concentration

Clean air supports brain health.

Seasonal Pollution in India

During winter months, many cities experience severe smog due to:

crop burning
temperature inversion
increased emissions

Monitoring Air Quality Index (AQI) helps individuals take precautions.

Signs of Pollution-Related Health Impact

persistent cough
chest tightness
eye irritation
unusual fatigue
worsening asthma

Individuals experiencing these symptoms should consult healthcare providers.

Preventive Measures to Reduce Exposure

Monitor AQI

Avoid outdoor activities during high pollution days.

Use Protective Masks

N95 masks filter fine particles effectively.

Indoor Air Quality

Use air purifiers and keep windows closed during peak pollution.

Avoid High-Traffic Areas

Limit time near busy roads.

Maintain Healthy Lifestyle

Strong immunity helps reduce pollution-related health risks.

Role of Preventive Healthcare

Regular screening for:

lung function
blood pressure
heart health

helps detect early damage caused by pollution.

Urban populations should prioritise routine health checkups.

Long-Term Public Health Impact

Air pollution contributes significantly to:

healthcare burden
productivity loss
economic strain

Preventive awareness and environmental policies are essential.

Conclusion

The impact of air pollution on human health is profound and far-reaching. From respiratory disorders and heart disease to immune suppression and increased cancer risk, polluted air affects nearly every organ system. In India’s urban environment, proactive measures such as monitoring AQI, using protective masks and maintaining regular health screenings are crucial. Protecting oneself from air pollution is not just about comfort—it is a vital step in preserving long-term health and preventing chronic disease.

References

World Health Organization (WHO) – Air Pollution and Health Reports
Indian Council of Medical Research (ICMR) – Environmental Health Studies
National Family Health Survey (NFHS-5) – Respiratory and Cardiovascular Data
NITI Aayog – Environmental and Preventive Health Strategy Reports
Lancet – Global Burden of Disease and Air Pollution Research

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