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Published on: Nov 13, 2020
1 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Using The Cellular Handshake Against The Virus

Using the cellular handshake against the virus

In early November an interesting study was published in The Lancet Respiratory Medicine, describing the treatment of a severe COVID-19 patient with human recombinant soluble angiotensin-converting enzyme-2. By using the treatment, it was possible to see the disappearance of the virus swiftly from the patient's serum, nose, and lungs, as well as a reduction in the patients’ inflammatory markers. How was this achieved? And why is this so intriguing.

When we look at treating viruses, there are several strategies at work. You can prevent its spread by the use of social distancing or masks, you can use medications that prevent its replication (such as Tamiflu). Or you can stop the virus from entering the cells, the first step in viral replication.

SARS-CoV-2 appears to enter human cells through the ACE2 receptor. ACE2 is a protein in the cell membrane found across the human body, especially the lungs, heart, kidney and small intestine. It function is related to the Renin-Angiotensin System, a mechanism by which the kidneys control your blood pressure.

Angiotensin-Converting Enzyme converts angiotensin 1 to angiotensin 2, a hormone that causes blood vessels to constrict. ACE 2 instead converts it to a protein that causes dilation of blood vessels. This likely protects these critical organs and ensure they receive sufficient blood to perform their tasks. ACE2 is being investigated as a possible target for blood pressure medications.

The study used a genetically modified soluble form of ACE2 that mimics the protein found on human cell membranes. By increasing its availability in the blood, the SARS-CoV-2 virus binds to this protein, resulting in its inactivation, rather than entering lung cells and causing lung injury. Lab studies have shown that it can reduce viral growth by as much as 1000 to 5000 times, and phase 1 studies show it to be safe to use in people.

The actual described case was in a 45-year-old woman, hospitalized with COVID, suffering from severe shortness of breath, cough and fatigue. She was first treated with hydroxychloroquine and anticoagulants, but this proved ineffective, and the virus was causing increasing damage to her lungs. Nine days after her symptoms started, she received the ACE2 treatment for a week, with no side effects. This resulted in an increase in ACE2 activity (seen from her blood results), but also a marked decrease in multiple inflammatory markers associated with COVID-19, as well as a sharp decrease in COVID 19 numbers. Indeed, the viral load dropped from 32,000 per mL to just 270 per mL two days after treatment started. She was also able to produce antibodies against the virus, so this did not impair her from getting immunity.

It is certainly a very interesting case, though questions remain on how feasible it would be (as well as how expensive) to manufacture large quantities of this protein receptor for treatment use, as well as how it fairs in clinical trials.

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Monthly Healthy Potluck at Health Hubs: Building Community-Centered Preventive Wellness in India

India is facing a growing burden of lifestyle-related health conditions, including diabetes, obesity, hypertension and heart disease. According to ICMR and NFHS-5 data, dietary habits play a central role in the development and prevention of these conditions. While awareness around nutrition is increasing, sustaining healthy eating habits remains a challenge for many individuals.

The Monthly Healthy Potluck at Health Hubs is a community-driven initiative designed to address this gap. By bringing people together around nutritious food, shared learning and expert guidance, these potlucks transform healthy eating from an individual responsibility into a collective experience.

SecondMedic supports these events as part of its broader preventive healthcare mission, combining community engagement with medical expertise and digital health tools.

Why Community-Based Nutrition Initiatives Matter in India

1. Rising lifestyle disease burden

ICMR reports show that diet-related conditions account for a significant proportion of non-communicable diseases in India. Excess sugar, refined carbohydrates and processed foods are common contributors.

2. Nutrition knowledge gaps

NFHS-5 highlights widespread deficiencies in:

protein intake
micronutrients
dietary diversity

Community events help translate knowledge into practice.

3. Behaviour change is easier together

Research published in The Lancet suggests that group-based interventions are more effective in sustaining lifestyle changes than isolated efforts.

4. Cultural relevance of shared meals

Food is deeply social in Indian culture. Potlucks leverage this tradition to promote healthier choices without imposing rigid rules.

What Is the Monthly Healthy Potluck at Health Hubs?

The Monthly Healthy Potluck is a recurring wellness event hosted at designated Health Hubs. Participants bring healthy, home-prepared dishes and engage in guided discussions about nutrition, ingredients and portion balance.

The goal is not calorie counting, but mindful, informed eating that aligns with preventive health principles.

Key Components of the Healthy Potluck Program

1. Nutritious Home-Cooked Food

Participants are encouraged to prepare dishes using:

whole grains
seasonal vegetables
lean proteins
healthy fats
minimal added sugar and salt

This showcases practical, everyday meals rather than restrictive diets.

2. Nutrition Education in Simple Language

Dietitians and healthcare professionals explain:

why certain ingredients are beneficial
how portion sizes affect metabolism
ways to modify traditional recipes for better health

This bridges the gap between theory and daily cooking.

3. Peer Learning and Motivation

Participants learn from each other’s recipes, challenges and successes. This shared experience builds motivation and accountability.

4. Preventive Health Focus

Discussions link food choices to prevention of:

diabetes
heart disease
obesity
gut disorders
nutrient deficiencies

The emphasis is on long-term wellbeing, not short-term fixes.

Who Can Benefit from Monthly Healthy Potlucks?

Working professionals

Learn quick, balanced meal ideas suited for busy schedules.

Families

Encourage healthier eating habits for children and elders alike.

Seniors

Focus on nutrient-dense foods that support ageing and immunity.

Individuals with lifestyle conditions

Gain practical guidance for diabetes-friendly, heart-healthy or weight-conscious meals.

Health-conscious individuals

Build consistency and community support around wellness goals.

The Role of Health Hubs in Preventive Care

Health Hubs act as physical spaces where preventive healthcare becomes accessible and engaging. By hosting regular potlucks, these hubs move beyond diagnostics and consultations to address everyday behaviours that shape health outcomes.

SecondMedic integrates these community activities with:

preventive screening programs
nutrition consultations
AI Health Guide insights
digital health records

This ensures that learning from the potluck translates into measurable health improvements.

How AI Health Guide Enhances Community Nutrition Programs

SecondMedic’s AI Health Guide complements potluck initiatives by:

• Identifying common dietary gaps

Based on participant data and screening results.

• Personalising recommendations

Aligns food choices with individual health profiles.

• Tracking progress over time

Monitors changes in weight, glucose, cholesterol and energy levels.

• Supporting expert guidance

Provides data-backed insights for dietitians during discussions.

This blend of community engagement and technology strengthens preventive outcomes.

Benefits of Monthly Healthy Potlucks

1. Improved nutrition awareness

Participants gain clarity on healthy ingredients and cooking methods.

2. Sustainable behaviour change

Monthly repetition reinforces habits without overwhelm.

3. Reduced reliance on processed food

Exposure to simple, healthy recipes encourages home cooking.

4. Stronger community bonds

Shared goals foster trust, motivation and support.

5. Alignment with preventive healthcare

Nutrition becomes a proactive tool for disease prevention.

Long-Term Impact on Public Health

Community-driven initiatives like healthy potlucks can have a significant impact on public health outcomes. According to WHO and NITI Aayog, population-level dietary improvements are among the most cost-effective strategies for reducing non-communicable diseases.

By normalising healthy eating through social interaction, Monthly Healthy Potlucks contribute to:

reduced lifestyle disease risk
improved dietary diversity
greater health literacy

How SecondMedic Supports and Scales These Initiatives

SecondMedic plays a key role in ensuring that these events are structured, evidence-based and scalable by providing:

• Expert involvement

Dietitians and doctors guide discussions.

• Digital follow-up

Participants receive personalised insights post-event.

• Preventive health integration

Links potluck learnings with screenings and consultations.

• Community engagement tools

Newsletters, reminders and educational resources maintain momentum.

Conclusion

The Monthly Healthy Potluck at Health Hubs represents a powerful shift in how preventive healthcare is delivered in India. By combining community participation, nutrition education and expert guidance, these events make healthy eating practical, enjoyable and sustainable. Supported by SecondMedic’s preventive healthcare ecosystem, healthy potlucks transform everyday food choices into long-term wellness strategies.

7?? References

ICMR – Dietary Patterns and Lifestyle Disease Prevention
National Family Health Survey (NFHS-5) – Nutrition and Health Indicators
NITI Aayog – Preventive Health and Community Wellness Reports
WHO – Community-Based Nutrition Interventions Guidelines
Lancet – Effectiveness of Group-Based Lifestyle Interventions
Statista – Nutrition Awareness and Preventive Health Trends India
EY-FICCI – Preventive Healthcare and Community Engagement Studies

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