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Published on: Nov 13, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

What Are Some Common Side Effects Of The COVID-19 Vaccine?

COVID Vaccine, the Pfizer update

On Monday Pfizer announced to the world the vaccine, once it has been developing with Germany's BioNTech, was found to be more than 90?fective. If this is substantiated, it may be possible for countries to receive the vaccine before the end of the year.

The Vaccine is an mRNA Vaccine, a novel method that introduces viral RNA into the body via a viral coat. The vaccine is incorporated into the person's cell, where the viral RNA is read and viral proteins are produced, including the coronavirus coat proteins. As the body reads and recognizes these proteins, it produces antibodies against these viral proteins and activates immune T cells against the virus.

The Pfizer results are based of a phase 3 clinical trial with 43, 538 participants with a diverse background. In this trial, the participants were split between those receiving a vaccine, and those who received a placebo with no effect. The vaccine is administered in two parts, with a 90?ficacy obtained 7 days after the second dose. This would mean a person is vaccinated just 28 days after the initial vaccination.

The FDA usually looks for a minimum 50?ficacy in vaccination when approving new vaccines. It may surprise you that the annual flu jab is also estimated to be 50?fective. The data from Pfizer was verified by an external, independent Data Monitoring Committee. It used data from 94 patients enrolled in the trial and subsequently developed COVID. It is from this groupset that 90% of efficacy is obtained. This is not the final data analysis, and further publications are expected in late November, with a potential FDA Emergency Use Authorisation approval if the data continues to show promise.

If approved, Pfizer has the ability to make 50 million shots before the end of the year, and 1.3 billion by the end of 2021. Many countries are clamoring for their fair share of these limited resources; the US has already negotiated 200m shots, UK 50m, and Germany (one of the major financers for the Pfizer vaccine) over 300m for European Countries.

We should emphasize that rapid vaccine development on this scale at this speed was unheard of prior to COVID. Usually, the animal studies for vaccines can take 1-2 years. In that time Pfizer and others have managed phase 1-3 clinical trials in humans, something that usually takes upwards of 10 years.

There are many unanswered questions that remain from this information.

How safe is the vaccine? Whilst safety information was not published, overall the vaccine appears to have minimal side effects. This is particularly difficult to state however since mRNA vaccines have never been used in people before.
Does the vaccine prevent transmission? In theory, yes. If you are immunized the replication of the virus should be limited significantly, so the number of viruses in each cough will be much lower. However, we do not have data to prove that there is no transmission, but that is also because we have very little data overall.
How long does the protection last? This is a very critical question. The 90?fectiveness rate was calculated just 7 days after the second shot, but it is likely this will change as data is collected over the long term. Some studies have suggested the antibody response fades within months following COVID infection. T Cell immunity on the other hand can stay for years, and it may be the effectiveness of creating a T cell immunity that dictates just how good this vaccine will be .

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Chest Pain While Breathing: Causes, Warning Signs, and When to Seek Urgent Care

Chest pain is one of the most alarming symptoms a person can experience, especially when it worsens during breathing. Chest pain while breathing, also known as pleuritic chest pain, often indicates involvement of the lungs, chest wall or surrounding structures. While some causes are mild, others can be life-threatening and require immediate medical attention.

In India, respiratory infections, air pollution, sedentary lifestyles and delayed medical care contribute significantly to chest-related symptoms.

What Does Chest Pain While Breathing Mean?

Chest pain while breathing refers to pain that:

worsens with deep inhalation or exhalation
may feel sharp, stabbing or burning
can be localized or spread across the chest

Pain intensity often increases with coughing or movement.

Common Causes of Chest Pain While Breathing

Lung Infections (Pneumonia)

Pneumonia inflames lung tissue and surrounding membranes.

Symptoms include:

chest pain while breathing
fever
cough
breathlessness

ICMR data identifies pneumonia as a major cause of respiratory illness in India.

Pleuritis (Inflammation of Lung Lining)

The pleura are thin membranes surrounding the lungs.

When inflamed:

breathing causes friction
sharp chest pain occurs

Pleuritis often follows viral infections or pneumonia.

Pulmonary Embolism

A blood clot in the lungs causes:

sudden chest pain
rapid breathing
severe breathlessness

This is a medical emergency requiring immediate care.

Chest Wall Muscle Strain

Muscle strain due to:

heavy lifting
intense coughing
poor posture

can cause pain during breathing or movement.

Costochondritis

Inflammation of rib cartilage causes:

localized chest pain
pain worsened by breathing or pressing on the chest

This condition is painful but not life-threatening.

Pneumothorax (Collapsed Lung)

Air leakage into the chest cavity causes:

sudden sharp chest pain
breathlessness

Often seen after trauma or in individuals with lung disease.

Heart-Related Causes

Though heart pain usually does not worsen with breathing, conditions such as:

pericarditis (heart lining inflammation)

can cause chest pain that changes with respiration.

Acid Reflux and Esophageal Spasm

Gastrointestinal causes may mimic chest pain.

However:

pain usually relates to meals
breathing-related pain should be evaluated carefully

Anxiety and Panic Disorders

Anxiety can cause:

chest tightness
rapid breathing
discomfort while breathing

Medical causes must be ruled out before attributing pain to anxiety.

Warning Signs That Require Emergency Attention

Seek immediate medical care if chest pain while breathing is associated with:

sudden onset
severe breathlessness
bluish lips or fingers
dizziness or fainting
sweating
coughing up blood

These may indicate life-threatening conditions.

Risk Factors for Serious Chest Pain

Higher risk occurs in people with:

smoking history
recent surgery or long travel
lung disease
heart disease
clotting disorders

Early evaluation is critical.

Diagnostic Evaluation

Doctors may recommend:

physical examination
chest X-ray
ECG
blood tests
CT scan

Timely diagnosis saves lives.

Why Chest Pain Should Not Be Ignored

Ignoring chest pain can lead to:

delayed treatment
worsening respiratory failure
preventable complications

WHO emphasises early symptom recognition for better outcomes.

Impact of Air Pollution and Lifestyle

Air pollution increases:

lung inflammation
infection risk

Sedentary habits reduce lung capacity, worsening symptoms.

Preventive Measures

Helpful preventive steps include:

avoiding smoking
staying physically active
managing respiratory infections early
maintaining good posture
staying hydrated

Preventive care reduces risk.

Role of Preventive Health Checkups

Regular health screening helps detect:

early lung disease
heart risk factors
chronic inflammation

Early intervention prevents emergencies.

When Chest Pain Is Less Likely Serious

Pain may be less concerning if:

localized
reproducible on touch
improves with rest

However, medical confirmation is still necessary.

Importance of Timely Medical Consultation

Chest pain should always be evaluated by a healthcare professional.

Delaying care can:

increase complications
raise mortality risk

Early action saves lives.

Conclusion

Chest pain while breathing is a critical symptom that should never be ignored. While causes range from muscle strain and infections to serious lung and heart conditions, only proper medical evaluation can determine the exact cause. Early diagnosis, timely treatment and preventive care are essential to protect respiratory and cardiovascular health. When it comes to chest pain, it is always safer to act early than to wait.

References

Indian Council of Medical Research (ICMR) – Respiratory and Cardiovascular Health Reports
World Health Organization (WHO) – Chest Pain and Respiratory Symptoms Guidelines
National Family Health Survey (NFHS-5) – Adult Respiratory Health Data
Lancet – Pulmonary Embolism and Chest Pain Research
NITI Aayog – Preventive Healthcare and Early Symptom Recognition

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