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Published on: Jul 29, 2021
2 minute read
By: Raj Dwivedi

What Tests Are Used To Manage Anemia And What Do They Mean?

The doctors use a number of tests to diagnose anemia. Hb (hemoglobin) is one of the key indicators used in diagnosis. A hemoglobin test is a blood test that measures how much hemoglobin you have in your red blood cells. A hemoglobin test is generally used for detecting:

In addition, a hemoglobin test can also be carried out to assess bone marrow's response to treatment, evaluate possible blood donation and check the levels of red blood cells in the body. There are certain conditions that may interfere with the results of the hemoglobin test. In such cases, it is recommended to get the test done again.

For the hemoglobin test, a sample of your blood is taken and tested in a clinical laboratory [read more about the process here]. The results are expressed as grams of hemoglobin per deciliter (g/dL) or micrograms per liter (mcg/L). Normal range for this test is 12g/dL - 18g/dL (12.1-18.0 g/L) for adults and 9g/dL - 13g/dL (9.0-13.3 g/L) for children. If the test result comes out to be less than 7 gm, it can indicate a serious condition known as severe anemia. In some cases, the doctors may order follow-up tests to assess the current condition of the patient.

Apart from the hemoglobin test, certain other blood tests can be used for detecting low RBCs (RBC count) or abnormal types of RBC (red cell indices) or hemoglobin (Hb). These include complete blood count tests, reticulocyte tests, iron tests, and red blood cell indices.

In some cases, the doctor may opt to do a bone marrow aspiration and exam to check for any abnormalities in the bone marrow cells. In such cases, it of red blood cells is karyotype to rule out chromosomal disorders.

The most common reason for having an inadequate number of red blood cells in the body is an iron deficiency or anemia. Iron plays a significant role in the production of hemoglobin, which is responsible for carrying oxygen from the lungs to the tissues of other parts of the body. Hence, people suffering from iron are known as sickle cell trait. The tests include:

Complete blood count test - The complete blood cell count (CBC) is a routine test that checks the different components of your blood like number of red blood cells, white blood cells and platelets. It also has information about the size and hemoglobin content in each of these cells. A CBC includes tests for the following:

Reticulocyte test - This is a blood test that measures the reticulocytes (immature red blood cells) in the bloodstream. A high level of reticulocytes can indicate increased production of red blood cells by the bone marrow to compensate for anemia, or destruction of very early stage RBCs which are still unable to mature.

Iron tests - Iron is an essential component for RBC production. A test to assess the iron level in your blood is called a serum ferritin test, which measures the amount of iron stored in the body's cells and tissues. Another way to evaluate low iron levels is by carrying out a transferrin saturation test. In this case, the lab technician will extract serum from your blood sample and measure the amount of transferrin protein present in it. Transferrin is a protein that carries iron to the bone marrow where red blood cells are produced. Thus, if there is an insufficient amount of transferrin protein present in the serum, it shows that there is an inadequate level of stored iron.

Hemoglobin tests - A hemoglobin test is generally carried out to detect anemia, especially if the result of CBC tests are inconclusive. During this test, a small sample of blood is collected from your vein and sent to the laboratory for analysis. The test measures the amount of hemoglobin in your red blood cells.

Red cell indices - Red cell indices are tests that measure the size and hemoglobin content of the red blood cells. The values obtained from these tests can be used to detect anemia and other blood disorders.

Karyotype test - It is a lab test used to evaluate chromosomal abnormalities in red blood cells or bone marrow cells

Low blood cell counts also have other causes, such as infections or tumors. In some cases, low blood cells may indicate a more serious condition like bone marrow failure which requires immediate medical intervention to save the patient from death.

Thus, if you are suffering from any of these conditions and symptoms and suspect that you may be anemic, check with your doctor for the necessary tests to confirm or rule out your suspicions. Early detection and treatment of anemia can save you from serious complications like heart attacks, strokes, blood clots, etc.

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Pale Skin Symptoms: Causes, Health Conditions, and When to Seek Medical Care

Skin colour provides important clues about internal health. When the skin becomes noticeably lighter than usual, it may indicate an underlying medical condition. Pale skin symptoms, also referred to as pallor, are commonly associated with reduced blood flow, low hemoglobin levels or impaired oxygen delivery to tissues.

In India, pale skin is frequently linked to anemia, nutritional deficiencies and chronic illnesses, making early recognition essential.

What Is Pale Skin?

Pale skin refers to:

lighter-than-normal skin tone
reduced redness
pale appearance of lips, gums or nail beds

It can affect the entire body or specific areas such as the face or hands.

Common Pale Skin Symptoms

Typical signs include:

pale face or complexion
pale lips or tongue
light-colored gums
pale nail beds
cold hands and feet
fatigue and weakness

These symptoms often occur together.

Most Common Causes of Pale Skin

Anemia

Anemia occurs when hemoglobin levels are low.

This reduces oxygen delivery to tissues, causing:

pale skin
fatigue
breathlessness
dizziness

NFHS-5 reports anemia affects a large proportion of Indian adults, especially women.

Iron Deficiency

Iron deficiency is the leading cause of anemia.

Contributing factors include:

poor dietary intake
blood loss
absorption problems

ICMR identifies iron deficiency as a major public health issue.

Poor Blood Circulation

Reduced circulation causes:

less blood reaching the skin
visible pallor

Conditions such as heart disease or shock impair circulation.

Acute Blood Loss

Sudden blood loss from:

injury
gastrointestinal bleeding
heavy menstrual bleeding

can cause rapid pallor and weakness.

Chronic Diseases

Chronic illnesses such as:

kidney disease
liver disease
cancer

often cause anemia and pallor over time.

Infections and Inflammation

Severe infections cause:

blood vessel constriction
redistribution of blood flow

This leads to pale or clammy skin.

Nutritional Deficiencies

Deficiencies of:

vitamin B12
folate

affect red blood cell production and cause pallor.

Hormonal Imbalance

Conditions like hypothyroidism reduce metabolic activity, causing:

pale, dry skin
fatigue

Thyroid disorders are common but underdiagnosed.

Genetic Conditions

Inherited disorders such as thalassemia affect hemoglobin production, leading to chronic pallor.

Pale Skin in Children and Older Adults

Children:

may develop pallor due to iron deficiency or infections

Older adults:

often develop pallor due to chronic disease or nutritional deficiency

Both groups need careful evaluation.

Warning Signs That Need Immediate Medical Attention

Seek urgent care if pale skin is associated with:

sudden weakness
chest pain
breathlessness
fainting
rapid heartbeat

These may indicate serious medical emergencies.

How Pale Skin Affects Daily Life

Persistent pallor often causes:

low energy
reduced physical endurance
difficulty concentrating

Quality of life may decline without treatment.

Diagnostic Evaluation

Doctors may recommend:

complete blood count
iron studies
vitamin B12 and folate levels
kidney and liver function tests

Identifying the cause is critical for treatment.

Role of Preventive Health Checkups

Preventive screening helps detect:

early anemia
nutritional deficiencies
chronic disease

Early treatment prevents complications.

Management and Treatment Options

Treatment depends on cause and may include:

iron or vitamin supplementation
treatment of underlying disease
dietary correction
medical therapy for chronic conditions

Self-treatment without diagnosis should be avoided.

Lifestyle Measures to Prevent Pallor

Helpful strategies include:

balanced diet rich in iron and vitamins
adequate hydration
regular health monitoring
treating infections early

Lifestyle changes support long-term health.

Importance of Early Detection

Ignoring pale skin delays diagnosis of:

anemia
internal bleeding
chronic illness

Early recognition improves outcomes.

Conclusion

Pale skin symptoms are more than a cosmetic concern. They often signal anemia, poor circulation, nutritional deficiencies or underlying medical conditions. While temporary pallor may occur due to minor causes, persistent or sudden pale skin requires medical evaluation. Early diagnosis, preventive health screening and appropriate treatment can restore normal skin tone, improve energy levels and protect long-term health.

References

Indian Council of Medical Research (ICMR) – Anemia and Nutritional Deficiency Reports
National Family Health Survey (NFHS-5) – Anemia and Adult Health Data
World Health Organization (WHO) – Anemia and Circulatory Health
Lancet – Pallor, Anemia and Chronic Disease Research
NITI Aayog – Preventive Healthcare and Early Symptom Detection

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